| Tau-centric multitarget approach for Alzheimer’s disease: development of first-in-class dual glycogen synthase kinase 3β and tau-aggregation inhibitors A Gandini, M Bartolini, D Tedesco, L Martinez-Gonzalez, C Roca, ... Journal of medicinal chemistry 61 (17), 7640-7656, 2018 | 104 | 2018 |
| Motor neuron preservation and decrease of in vivo TDP-43 phosphorylation by protein CK-1δ kinase inhibitor treatment L Martínez-González, C Rodríguez-Cueto, D Cabezudo, F Bartolomé, ... Scientific reports 10 (1), 4449, 2020 | 59 | 2020 |
| Interference of the complex between NCS-1 and Ric8a with phenothiazines regulates synaptic function and is an approach for fragile X syndrome A Mansilla, A Chaves-Sanjuan, NE Campillo, O Semelidou, ... Proceedings of the National Academy of Sciences 114 (6), E999-E1008, 2017 | 43 | 2017 |
| Development of Blood–Brain Barrier Permeable Nitrocatechol-Based Catechol O-Methyltransferase Inhibitors with Reduced Potential for Hepatotoxicity T Silva, T Mohamed, A Shakeri, PPN Rao, L Martinez-Gonzalez, DI Perez, ... Journal of Medicinal Chemistry 59 (16), 7584-7597, 2016 | 42 | 2016 |
| Derivatives of the β-crinane Amaryllidaceae alkaloid haemanthamine as multi-target directed ligands for Alzheimer’s disease E Kohelová, R Peřinová, N Maafi, J Korábečný, D Hulcová, J Maříková, ... Molecules 24 (7), 1307, 2019 | 38 | 2019 |
| Targeting nuclear protein TDP-43 by cell division cycle kinase 7 inhibitors: A new therapeutic approach for amyotrophic lateral sclerosis E Rojas-Prats, L Martinez-Gonzalez, C Gonzalo-Consuegra, NF Liachko, ... European Journal of Medicinal Chemistry 210, 112968, 2021 | 36 | 2021 |
| Recapitulation of pathological TDP-43 features in immortalized lymphocytes from sporadic ALS patients D Posa, L Martínez-González, F Bartolomé, S Nagaraj, G Porras, ... Molecular neurobiology 56, 2424-2432, 2019 | 34 | 2019 |
| Novel curcumin-diethyl fumarate hybrid as a dualistic GSK-3β inhibitor/Nrf2 inducer for the treatment of Parkinson’s disease RMC Di Martino, L Pruccoli, A Bisi, S Gobbi, A Rampa, A Martinez, ... ACS Chemical Neuroscience 11 (17), 2728-2740, 2020 | 33 | 2020 |
| Potential anti-Alzheimer effects of selected Lamiaceae plants through polypharmacology on glycogen synthase kinase-3β, β-secretase, and casein kinase 1δ P Gürbüz, A Martinez, C Perez, L Martinez-Gonzalez, F Göger, I Ayran Industrial crops and products 138, 111431, 2019 | 32 | 2019 |
| TDP-43 modulation by tau-tubulin kinase 1 inhibitors: A new avenue for future amyotrophic lateral sclerosis therapy V Nozal, L Martínez-González, M Gomez-Almeria, C Gonzalo-Consuegra, ... Journal of Medicinal Chemistry 65 (2), 1585-1607, 2022 | 29 | 2022 |
| Tideglusib, a non-ATP competitive inhibitor of GSK-3β as a drug candidate for the treatment of amyotrophic lateral sclerosis L Martínez-González, C Gonzalo-Consuegra, M Gómez-Almería, G Porras, ... International Journal of Molecular Sciences 22 (16), 8975, 2021 | 26 | 2021 |
| Therapeutic potential of novel Cell Division Cycle Kinase 7 inhibitors on TDP‐43‐related pathogenesis such as Frontotemporal Lobar Degeneration (FTLD) and amyotrophic lateral … G Vaca, L Martinez‐Gonzalez, A Fernandez, E Rojas‐Prats, G Porras, ... Journal of neurochemistry 156 (3), 379-390, 2021 | 23 | 2021 |
| A focused library of psychotropic analogues with neuroprotective and neuroregenerative potential E Uliassi, LE Peña-Altamira, AV Morales, F Massenzio, S Petralla, ... ACS Chemical Neuroscience 10 (1), 279-294, 2018 | 19 | 2018 |
| Increasing brain permeability of PHA-767491, a cell division cycle 7 kinase inhibitor, with biodegradable polymeric nanoparticles E Rojas-Prats, C Tosat-Bitrián, L Martínez-González, V Nozal, DI Pérez, ... Pharmaceutics 13 (2), 180, 2021 | 17 | 2021 |
| Computer-aided molecular design of pyrazolotriazines targeting glycogen synthase kinase 3 ML Sciú, V Sebastián-Pérez, L Martinez-Gonzalez, R Benitez, DI Perez, ... Journal of enzyme inhibition and medicinal chemistry 34 (1), 87-96, 2019 | 16 | 2019 |
| Chameleon-like behavior of indolylpiperidines in complex with cholinesterases targets: Potent butyrylcholinesterase inhibitors TPC Chierrito, S Pedersoli-Mantoani, C Roca, V Sebastian-Perez, ... European Journal of Medicinal Chemistry 145, 431-444, 2018 | 16 | 2018 |
| Insights into real-time chemical processes in a calcium sensor protein-directed dynamic library A Canal-Martín, J Sastre, MJ Sánchez-Barrena, A Canales, S Baldominos, ... Nature Communications 10 (1), 2798, 2019 | 15 | 2019 |
| Deciphering the inhibition of the neuronal calcium sensor 1 and the guanine exchange factor Ric8a with a small phenothiazine molecule for the rational generation of therapeutic … C Roca, L Martinez-Gonzalez, M Daniel-Mozo, J Sastre, L Infantes, ... Journal of Medicinal Chemistry 61 (14), 5910-5921, 2018 | 12 | 2018 |
