Grazyna Kochan
Grazyna Kochan
Team Leader
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Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility
DM Evans, CCA Spencer, JJ Pointon, Z Su, D Harvey, G Kochan, ...
Nature genetics 43 (8), 761-767, 2011
Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming
G Kochan, T Krojer, D Harvey, R Fischer, L Chen, M Vollmar, F von Delft, ...
Proceedings of the National Academy of Sciences 108 (19), 7745-7750, 2011
Role of non-classical MHC class I molecules in cancer immunosuppression
G Kochan, D Escors, K Breckpot, D Guerrero-Setas
Oncoimmunology 2 (11), e26491, 2013
Structural snapshots for the conformation-dependent catalysis by human medium-chain acyl-coenzyme A synthetase ACSM2A
G Kochan, ES Pilka, F von Delft, U Oppermann, WW Yue
Journal of molecular biology 388 (5), 997-1008, 2009
Structures of the human GTPase MMAA and vitamin B12-dependent methylmalonyl-CoA mutase and insight into their complex formation
DS Froese, G Kochan, JRC Muniz, X Wu, C Gileadi, E Ugochukwu, ...
Journal of Biological Chemistry 285 (49), 38204-38213, 2010
Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases
NR Rose, ECY Woon, A Tumber, LJ Walport, R Chowdhury, XS Li, ...
Journal of medicinal chemistry 55 (14), 6639-6643, 2012
PD1 signal transduction pathways in T cells
H Arasanz, M Gato-Cañas, M Zuazo, M Ibañez-Vea, K Breckpot, ...
Oncotarget 8 (31), 51936, 2017
PDL1 signals through conserved sequence motifs to overcome interferon-mediated cytotoxicity
M Gato-Cañas, M Zuazo, H Arasanz, M Ibañez-Vea, L Lorenzo, ...
Cell reports 20 (8), 1818-1829, 2017
Crystal structure of the 2-oxoglutarate-and Fe (II)-dependent lysyl hydroxylase JMJD6
M Mantri, T Krojer, EA Bagg, CJ Webby, DS Butler, G Kochan, ...
Journal of molecular biology 401 (2), 211-222, 2010
Structural and mechanistic studies on γ-butyrobetaine hydroxylase
IKH Leung, TJ Krojer, GT Kochan, L Henry, F von Delft, TDW Claridge, ...
Chemistry & biology 17 (12), 1316-1324, 2010
MVA-LACK as a safe and efficient vector for vaccination against leishmaniasis
E Pérez-Jiménez, G Kochan, MM Gherardi, M Esteban
Microbes and infection 8 (3), 810-822, 2006
The intracellular signalosome of PD-L1 in cancer cells
D Escors, M Gato-Cañas, M Zuazo, H Arasanz, MJ García-Granda, R Vera, ...
Signal transduction and targeted therapy 3 (1), 1-9, 2018
Structural basis for substrate specificity in human monomeric carbonyl reductases
ES Pilka, FH Niesen, WH Lee, Y El-Hawari, JE Dunford, G Kochan, ...
PloS one 4 (10), e7113, 2009
A highly efficient tumor-infiltrating MDSC differentiation system for discovery of anti-neoplastic targets, which circumvents the need for tumor establishment in mice
T Liechtenstein, N Perez-Janices, M Gato, F Caliendo, G Kochan, ...
Oncotarget 5 (17), 7843, 2014
Membrane cell fusion activity of the vaccinia virus A17–A27 protein complex
G Kochan, D Escors, JM González, JM Casasnovas, M Esteban
Cellular microbiology 10 (1), 149-164, 2008
Role of severe acute respiratory syndrome coronavirus viroporins E, 3a, and 8a in replication and pathogenesis
C Castaño-Rodriguez, JM Honrubia, J Gutiérrez-Álvarez, ML DeDiego, ...
MBio 9 (3), 2018
Crystal structure of the secretory isozyme of mammalian carbonic anhydrases CA VI: implications for biological assembly and inhibitor development
ES Pilka, G Kochan, U Oppermann, WW Yue
Biochemical and Biophysical Research Communications 419 (3), 485-489, 2012
Thermolability of mutant MMACHC protein in the vitamin B12-responsive cblC disorder
DS Froese, S Healy, M McDonald, G Kochan, U Oppermann, FH Niesen, ...
Molecular genetics and metabolism 100 (1), 29-36, 2010
Crystal structure of human carbonic anhydrase‐related protein VIII reveals the basis for catalytic silencing
SS Picaud, JRC Muniz, A Kramm, ES Pilka, G Kochan, U Oppermann, ...
Proteins: Structure, Function, and Bioinformatics 76 (2), 507-511, 2009
Fibrosis assessment in patients with chronic hepatitis B virus (HBV) infection
P Parikh, JD Ryan, EA Tsochatzis
Annals of translational medicine 5 (3), 2017
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