Next-generation sequencing of the Chinese hamster ovary microRNA transcriptome: Identification, annotation and profiling of microRNAs as targets for cellular engineering M Hackl, T Jakobi, J Blom, D Doppmeier, K Brinkrolf, R Szczepanowski, ... Journal of biotechnology 153 (1-2), 62-75, 2011 | 125 | 2011 |
Dynamic mRNA and miRNA profiling of CHO‐K1 suspension cell cultures JAH Bort, M Hackl, H Höflmayer, V Jadhav, E Harreither, N Kumar, ... Biotechnology journal 7 (4), 500-515, 2012 | 106 | 2012 |
Stable overexpression of miR-17 enhances recombinant protein production of CHO cells V Jadhav, M Hackl, G Klanert, JAH Bort, R Kunert, J Grillari, N Borth Journal of biotechnology 175, 38-44, 2014 | 86 | 2014 |
A screening method to assess biological effects of microRNA overexpression in Chinese hamster ovary cells V Jadhav, M Hackl, JA Hernandez Bort, M Wieser, E Harreither, R Kunert, ... Biotechnology and bioengineering 109 (6), 1376-1385, 2012 | 64 | 2012 |
Growth, productivity and protein glycosylation in a CHO EpoFc producer cell line adapted to glutamine-free growth M Taschwer, M Hackl, JAH Bort, C Leitner, N Kumar, U Puc, J Grass, ... Journal of biotechnology 157 (2), 295-303, 2012 | 61 | 2012 |
Utilization and evaluation of CHO‐specific sequence databases for mass spectrometry based proteomics P Meleady, R Hoffrogge, M Henry, O Rupp, JH Bort, C Clarke, K Brinkrolf, ... Biotechnology and bioengineering 109 (6), 1386-1394, 2012 | 58 | 2012 |
CHO‐K1 host cells adapted to growth in glutamine‐free medium by FACS‐assisted evolution JAH Bort, B Stern, N Borth Biotechnology Journal 5 (10), 1090-1097, 2010 | 48 | 2010 |
A signature of 12 microRNAs is robustly associated with growth rate in a variety of CHO cell lines G Klanert, V Jadhav, V Shanmukam, A Diendorfer, M Karbiener, ... Journal of Biotechnology 235, 150-161, 2016 | 26 | 2016 |
Reduced quenching and extraction time for mammalian cells using filtration and syringe extraction JAH Bort, V Shanmukam, M Pabst, M Windwarder, L Neumann, ... Journal of Biotechnology 182, 97-103, 2014 | 23 | 2014 |
A metabolic CRISPR-Cas9 screen in Chinese hamster ovary cells identifies glutamine-sensitive genes KJ la Cour Karottki, H Hefzi, S Li, LE Pedersen, PN Spahn, C Joshi, ... Metabolic engineering 66, 114-122, 2021 | 20 | 2021 |
Assessment of the percentage of full recombinant adeno-associated virus particles in a gene therapy drug using CryoTEM SIM Colomb-Delsuc M, Raim R, Fiedler C, Reuberger S, Lengler J, Nordström R ... Plos One 3 (17), 2022 | 10* | 2022 |
Challenges in the downstream process of gene therapy products JA Hernandez Bort Am Pharm Rev. 22 (4), 2019 | 6 | 2019 |
Proton-transfer-reaction mass spectrometry (PTR-MS) for online monitoring of glucose depletion and cell concentrations in HEK 293 gene therapy processes HBJA Bayer B, Maccani A, Jahn J, Duerkop M, Kapeller E, Pletzenauer R, Kraus ... Plos 1 44 (1), 77-88, 2022 | 4* | 2022 |
Scaling strategy for cell and gene therapy bioreactors based on turbulent parameters D Iurashev, PA Jones, N Andreev, Y Wang, T Iwata‐Kajihara, B Kraus, ... Biotechnology Journal 19 (1), 2300235, 2024 | 2 | 2024 |
Comprehensive mRNA‐sequencing‐based characterization of three HEK‐293 cell lines during an rAAV production process for gene therapy applications M Pistek, CI Kahlig, M Hackl, S Unterthurner, B Kraus, R Grabherr, ... Biotechnology Journal 18 (8), 2200513, 2023 | 2 | 2023 |
Optimizing VLP production in gene therapy: Opportunities and challenges for in silico modeling L Zehetner, D Széliová, B Kraus, M Graninger, J Zanghellini, ... Biotechnology Journal 18 (7), 2200636, 2023 | 1 | 2023 |
Enhancement of rAAV titers via inhibition of the interferon signaling cascade in transfected HEK293 suspension cultures CI Kahlig, S Moser, L Micutkova, G J., B Kraus, JA Hernandez Bort Biotechnology Journal, https://analyticalsciencejournals.onlinelibrary.wiley …, 2024 | | 2024 |
Factors affecting recombinant Adeno-Associated Virus titers during triple-plasmid transient transfection in HEK-293 cells M Pistek, P Andorfer, R Grabherr, B Kraus, JAH Bort | | 2024 |
Characterizing the Biopotency of Truncated Transgene Variants in rAAV8 viral vectors: Essential Considerations for Gene Therapy Applications C Fiedler, J Lengler, B Gruber, M Scheindel, C Büngener, ... | | 2024 |
Differential logistic PCA for large-scale comparison of GSMMs and pathway analysis L Zehetner, D Szeliova, B Kraus, J Hernandez Bort, J Zanghellini bioRxiv, 2023.11. 27.568810, 2023 | | 2023 |