| Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia AE Tron, MA Belmonte, A Adam, BM Aquila, LH Boise, E Chiarparin, ... Nature communications 9 (1), 5341, 2018 | 437 | 2018 |
| Photoredox mediated nickel catalyzed cross-coupling of thiols with aryl and heteroaryl iodides via thiyl radicals MS Oderinde, M Frenette, DW Robbins, B Aquila, JW Johannes Journal of the American Chemical Society 138 (6), 1760-1763, 2016 | 390 | 2016 |
| Iridium-catalyzed, silyl-directed borylation of nitrogen-containing heterocycles DW Robbins, TA Boebel, JF Hartwig Journal of the American Chemical Society 132 (12), 4068-4069, 2010 | 333 | 2010 |
| A simple, multidimensional approach to high-throughput discovery of catalytic reactions DW Robbins, JF Hartwig Science 333 (6048), 1423-1427, 2011 | 267 | 2011 |
| Highly Chemoselective Iridium Photoredox and Nickel Catalysis for the Cross‐Coupling of Primary Aryl Amines with Aryl Halides MS Oderinde, NH Jones, A Juneau, M Frenette, B Aquila, S Tentarelli, ... Angewandte Chemie 128 (42), 13413-13417, 2016 | 170 | 2016 |
| AC–H borylation approach to Suzuki–Miyaura coupling of typically unstable 2–heteroaryl and polyfluorophenyl boronates DW Robbins, JF Hartwig Organic letters 14 (16), 4266-4269, 2012 | 126 | 2012 |
| Catalytic enantioselective addition of organoboron reagents to fluoroketones controlled by electrostatic interactions KA Lee, DL Silverio, S Torker, DW Robbins, F Haeffner, FW van der Mei, ... Nature chemistry 8 (8), 768-777, 2016 | 117 | 2016 |
| Sterically Controlled Alkylation of Arenes through Iridium‐Catalyzed C H Borylation DW Robbins, JF Hartwig Angewandte Chemie International Edition 52 (3), 933-937, 2013 | 104 | 2013 |
| Effects of molecular oxygen, solvent, and light on iridium-photoredox/nickel dual-catalyzed cross-coupling reactions MS Oderinde, A Varela-Alvarez, B Aquila, DW Robbins, JW Johannes The Journal of Organic Chemistry 80 (15), 7642-7651, 2015 | 100 | 2015 |
| Structure based design of non-natural peptidic macrocyclic Mcl-1 inhibitors JW Johannes, S Bates, C Beigie, MA Belmonte, J Breen, S Cao, ... ACS medicinal chemistry letters 8 (2), 239-244, 2017 | 71 | 2017 |
| Practical and Broadly Applicable Catalytic Enantioselective Additions of Allyl‐B (pin) Compounds to Ketones and α‐Ketoesters DW Robbins, KA Lee, DL Silverio, A Volkov, S Torker, AH Hoveyda Angewandte Chemie 128 (33), 9762-9766, 2016 | 57 | 2016 |
| Structure‐based design of selective noncovalent CDK12 inhibitors JW Johannes, CR Denz, N Su, A Wu, AC Impastato, S Mlynarski, ... ChemMedChem 13 (3), 231-235, 2018 | 43 | 2018 |
| Nickel-catalyzed anti-selective alkyne functionalization reactions SE Bottcher, LE Hutchinson, DJ Wilger Synthesis 52 (19), 2807-2820, 2020 | 34 | 2020 |
| Nx-2127, a degrader of BTK and IMiD neosubstrates, for the treatment of B-cell malignancies DW Robbins, A Kelly, M Tan, J McIntosh, J Wu, Z Konst, D Kato, G Peng, ... Blood 136, 34, 2020 | 29 | 2020 |
| A Novel method for the direct synthesis of symmetrical and unsymmetrical sulfides and disulfides from aryl halides and ethyl potassium xanthogenate M Soleiman-Beigi, Z Arzehgar Synlett 29 (07), 986-992, 2018 | 29 | 2018 |
| Nx-5948, a selective degrader of BTK with activity in preclinical models of hematologic and brain malignancies DW Robbins, M Noviski, R Rountree, M Tan, N Brathaban, T Ingallinera, ... Blood 138, 2251, 2021 | 20 | 2021 |
| MCL-1 inhibitors and methods of use thereof A Hird, Y Wenzhan, D Robbins, S Kazmirski, D Wu, B Peng, J Johannes, ... US Patent 9,840,518, 2017 | 17 | 2017 |
| Synthetic Access to 3, 5, 7-Trisubstituted Indoles Enabled by Iridium-Catalyzed C–H Borylation AS Eastabrook, J Sperry Synthesis 49 (21), 4731-4737, 2017 | 16 | 2017 |
| Iridium-Catalyzed Asymmetric C–H Borylation Enabled by Chiral Bidentate Boryl Ligands Y Shi, Q Gao, S Xu Synlett 30 (19), 2107-2112, 2019 | 15 | 2019 |
| NRX-0492 degrades wild-type and C481 mutant BTK and demonstrates in vivo activity in CLL patient-derived xenografts D Zhang, HM Harris, J Chen, J Judy, G James, A Kelly, J McIntosh, ... Blood 141 (13), 1584-1596, 2023 | 12 | 2023 |
Jeffrey W. JohannesAstraZenecaVerified email at astrazeneca.com
