| The Photocycle of Channelrhodopsin‐2: Ultrafast Reaction Dynamics and Subsequent Reaction Steps MK Verhoefen, C Bamann, R Blöcher, U Förster, E Bamberg, J Wachtveitl ChemPhysChem 11 (14), 3113-3122, 2010 | 94 | 2010 |
| Lipoxin and resolvin biosynthesis is dependent on 5‐lipoxygenase activating protein C Lehmann, J Homann, AK Ball, R Blöcher, TK Kleinschmidt, ... The FASEB Journal 29 (12), 5029-5043, 2015 | 89 | 2015 |
| N-Benzylbenzamides: A Novel Merged Scaffold for Orally Available Dual Soluble Epoxide Hydrolase/Peroxisome Proliferator-Activated Receptor γ Modulators R Blöcher, C Lamers, SK Wittmann, D Merk, M Hartmann, L Weizel, ... Journal of medicinal chemistry 59 (1), 61-81, 2016 | 51 | 2016 |
| A novel dual PPAR-γ agonist/sEH inhibitor treats diabetic complications in a rat model of type 2 diabetes MA Hye Khan, L Kolb, M Skibba, M Hartmann, R Blöcher, E Proschak, ... Diabetologia 61, 2235-2246, 2018 | 43 | 2018 |
| Exploring the chemical space of multitarget ligands using aligned self-organizing maps J Achenbach, FM Klingler, R Blöcher, D Moser, AK Häfner, CB Rödl, ... ACS Medicinal Chemistry Letters 4 (12), 1169-1172, 2013 | 37 | 2013 |
| Design and synthesis of dual modulators of soluble epoxide hydrolase and peroxisome proliferator-activated receptors E Buscató, R Blöcher, C Lamers, FM Klingler, S Hahn, D Steinhilber, ... Journal of medicinal chemistry 55 (23), 10771-10775, 2012 | 29 | 2012 |
| In vitro and in vivo Metabolism of a Potent Inhibitor of Soluble Epoxide Hydrolase, 1-(1-Propionylpiperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea D Wan, J Yang, CB McReynolds, B Barnych, KM Wagner, C Morisseau, ... Frontiers in pharmacology 10, 464, 2019 | 28 | 2019 |
| Design, synthesis, and evaluation of alkyl-quinoxalin-2 (1 H)-one derivatives as anti-quorum sensing molecules, inhibiting biofilm formation in Aeromonas caviae Sch3 R Blöcher, A Rodarte Ramírez, G Castro-Escarpulli, E Curiel-Quesada, ... Molecules 23 (12), 3075, 2018 | 24 | 2018 |
| Dual soluble epoxide hydrolase inhibitor/PPAR-γ agonist attenuates renal fibrosis A Stavniichuk, MAH Khan, MM Yeboah, MA Chesnik, WK Jankiewicz, ... Prostaglandins & Other Lipid Mediators 150, 106472, 2020 | 21 | 2020 |
| Design, synthesis and cellular characterization of a dual inhibitor of 5-lipoxygenase and soluble epoxide hydrolase K Meirer, D Glatzel, S Kretschmer, SK Wittmann, M Hartmann, R Blöcher, ... Molecules 22 (1), 45, 2016 | 20 | 2016 |
| Orally available soluble epoxide hydrolase/phosphodiesterase 4 dual inhibitor treats inflammatory pain R Blöcher, KM Wagner, RR Gopireddy, TR Harris, H Wu, B Barnych, ... Journal of medicinal chemistry 61 (8), 3541-3550, 2018 | 19 | 2018 |
| PENG: a neural gas-based approach for pharmacophore elucidation. Method design, validation, and virtual screening for novel ligands of LTA4H D Moser, SK Wittmann, J Kramer, R Blöcher, J Achenbach, ... Journal of Chemical Information and Modeling 55 (2), 284-293, 2015 | 16 | 2015 |
| Thermodynamic properties of leukotriene A4 hydrolase inhibitors SK Wittmann, L Kalinowsky, JS Kramer, R Bloecher, S Knapp, ... Bioorganic & medicinal chemistry 24 (21), 5243-5248, 2016 | 13 | 2016 |
| Design of Dual Inhibitors of Soluble Epoxide Hydrolase and LTA4 Hydrolase K Hiesinger, A Schott, JS Kramer, R Blöcher, F Witt, SK Wittmann, ... ACS Medicinal Chemistry Letters 11 (3), 298-302, 2019 | 10 | 2019 |
| Design and synthesis of fused soluble epoxide hydrolase/peroxisome proliferator-activated receptor modulators R Blöcher, C Lamers, SK Wittmann, O Diehl, T Hanke, D Merk, ... MedChemComm 7 (6), 1209-1216, 2016 | 8 | 2016 |
| Drug-Mediated Intracellular Donation of Nitric Oxide Potently Inhibits 5-Lipoxygenase: A Possible Key to Future Antileukotriene Therapy J Roos, M Peters, IV Maucher, B Kühn, J Fettel, N Hellmuth, C Brat, ... Antioxidants & redox signaling, 2017 | 4 | 2017 |
| Diabetes and metabolic syndrome treatment with a novel dual modulator of soluble epoxide hydrolase and peroxisome proliferator-activated receptors JD Imig, MAH Khan, E Proschak, R Blocher US Patent 11,447,445, 2022 | 2 | 2022 |
| A Dual Soluble Epoxide Hydrolase Inhibitor/PPAR‐γ Agonist Prevents Renal Fibrosis in Mouse Unilateral Ureteral Obstruction Model AH Khan, A Stavniichuk, MM Yeboah, MA Chesnik, M Hartmann, ... The FASEB Journal 33 (S1), 678.12-678.12, 2019 | 1 | 2019 |
| Dual Soluble Epoxide Hydrolase Inhibitor/PPAR‐γ Agonist Reduces Kidney Injury In Metabolic Syndrome Rat J Birschbach, MAH Khan, A Sharma, M Hartmann, R Blöcher, E Proschak, ... The FASEB Journal 30, 740.5-740.5, 2016 | 1 | 2016 |
| Synthesis of Antiprotozoal 2-(4-Alkyloxyphenyl)-Imidazolines and Imidazoles and Their Evaluation on Leishmania mexicana and Trypanosoma cruzi J Torres-Jaramillo, R Blöcher, KF Chacón-Vargas, J Hernández-Calderón, ... International Journal of Molecular Sciences 25 (7), 3673, 2024 | | 2024 |
Proschak EJunior Professor in Drug Design Correu electrònic verificat a bioinformatik.uni-frankfurt.de
