| Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond M Platten, EAA Nollen, UF Röhrig, F Fallarino, CA Opitz Nature reviews Drug discovery 18 (5), 379-401, 2019 | 928 | 2019 |
| Chaperoning signaling pathways: molecular chaperones as stress-sensingheat shock'proteins EAA Nollen, RI Morimoto Journal of cell science 115 (14), 2809-2816, 2002 | 860 | 2002 |
| Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation EAA Nollen, SM Garcia, G Van Haaften, S Kim, A Chavez, RI Morimoto, ... Proceedings of the National Academy of Sciences 101 (17), 6403-6408, 2004 | 502 | 2004 |
| C. elegans Model Identifies Genetic Modifiers of α-Synuclein Inclusion Formation During Aging TJ Van Ham, KL Thijssen, R Breitling, RMW Hofstra, RHA Plasterk, ... PLoS genetics 4 (3), e1000027, 2008 | 465 | 2008 |
| Polyglutamine protein aggregates are dynamic S Kim, EAA Nollen, K Kitagawa, VP Bindokas, RI Morimoto Nature cell biology 4 (10), 826-831, 2002 | 349 | 2002 |
| In vivo chaperone activity of heat shock protein 70 and thermotolerance EAA Nollen, JF Brunsting, H Roelofsen, LA Weber, HH Kampinga Molecular and cellular biology 19 (3), 2069-2079, 1999 | 304 | 1999 |
| A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity M Perni, C Galvagnion, A Maltsev, G Meisl, MBD Müller, PK Challa, ... Proceedings of the National Academy of Sciences 114 (6), E1009-E1017, 2017 | 300 | 2017 |
| Tryptophan metabolism in inflammaging: from biomarker to therapeutic target FJH Sorgdrager, PJW Naudé, IP Kema, EA Nollen, PPD Deyn Frontiers in immunology 10, 2565, 2019 | 257 | 2019 |
| Delaying aging and the aging-associated decline in protein homeostasis by inhibition of tryptophan degradation AT Van Der Goot, W Zhu, RP Vázquez-Manrique, RI Seinstra, K Dettmer, ... Proceedings of the National Academy of Sciences 109 (37), 14912-14917, 2012 | 221 | 2012 |
| An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Aβ42 aggregates linked with Alzheimer’s disease J Habchi, P Arosio, M Perni, AR Costa, M Yagi-Utsumi, P Joshi, S Chia, ... Science advances 2 (2), e1501244, 2016 | 216 | 2016 |
| Bag1 functions in vivo as a negative regulator of Hsp70 chaperone activity EAA Nollen, JF Brunsting, J Song, HH Kampinga, RI Morimoto Molecular and cellular biology 20 (3), 1083-1088, 2000 | 184 | 2000 |
| Identification of MOAG-4/SERF as a regulator of age-related proteotoxicity TJ van Ham, MA Holmberg, AT van der Goot, E Teuling, ... Cell 142 (4), 601-612, 2010 | 175 | 2010 |
| Tryptophan metabolism: entering the field of aging and age-related pathologies AT Van der Goot, EAA Nollen Trends in molecular medicine 19 (6), 336-344, 2013 | 168 | 2013 |
| A screening-based platform for the assessment of cellular respiration in Caenorhabditis elegans M Koopman, H Michels, BM Dancy, R Kamble, L Mouchiroud, J Auwerx, ... Nature protocols 11 (10), 1798-1816, 2016 | 167 | 2016 |
| Modulation of in vivo HSP70 chaperone activity by Hip and Bag-1 EAA Nollen, AE Kabakov, JF Brunsting, B Kanon, J Höhfeld, ... Journal of Biological Chemistry 276 (7), 4677-4682, 2001 | 155 | 2001 |
| Dynamic changes in the localization of thermally unfolded nuclear proteins associated with chaperone-dependent protection EAA Nollen, FA Salomons, JF Brunsting, JJL Want, OCM Sibon, ... Proceedings of the National Academy of Sciences 98 (21), 12038-12043, 2001 | 141 | 2001 |
| Extracellular 4′-phosphopantetheine is a source for intracellular coenzyme A synthesis B Srinivasan, M Baratashvili, M Van Der Zwaag, B Kanon, C Colombelli, ... Nature chemical biology 11 (10), 784-792, 2015 | 132 | 2015 |
| Chaperone proteostasis in Parkinson's disease: Stabilization of the Hsp70/α‐synuclein complex by Hip C Roodveldt, CW Bertoncini, A Andersson, AT Van Der Goot, ST Hsu, ... The EMBO journal 28 (23), 3758-3770, 2009 | 130 | 2009 |
| A FRET sensor for non‐invasive imaging of amyloid formation in vivo GS Kaminski Schierle, CW Bertoncini, FTS Chan, AT Van Der Goot, ... ChemPhysChem 12 (3), 673-680, 2011 | 122 | 2011 |
| Discovery and functional prioritization of Parkinson’s disease candidate genes from large-scale whole exome sequencing IE Jansen, H Ye, S Heetveld, MC Lechler, H Michels, RI Seinstra, ... Genome biology 18, 1-26, 2017 | 119 | 2017 |
