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Amit U Sinha
Amit U Sinha
Instructor, Dana-Farber Cancer Inst and Harvard Medical School
Dirección de correo verificada de dfci.harvard.edu - Página principal
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MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L
KM Bernt, N Zhu, AU Sinha, S Vempati, J Faber, AV Krivtsov, Z Feng, ...
Cancer cell 20 (1), 66-78, 2011
9432011
The Wnt/β-catenin pathway is required for the development of leukemia stem cells in AML
Y Wang, AV Krivtsov, AU Sinha, TE North, W Goessling, Z Feng, LI Zon, ...
Science 327 (5973), 1650-1653, 2010
8912010
Chromatin-modifying enzymes as modulators of reprogramming
TT Onder, N Kara, A Cherry, AU Sinha, N Zhu, KM Bernt, P Cahan, ...
Nature, 2012
7542012
Mapping human genetic diversity in Asia
HUGO Pan-Asian SNP Consortium, MA Abdulla, I Ahmed, ...
Science 326 (5959), 1541-1545, 2009
6732009
H3K79 methylation profiles define murine and human MLL-AF4 leukemias
AV Krivtsov, Z Feng, ME Lemieux, J Faber, S Vempati, AU Sinha, X Xia, ...
Cancer cell 14 (5), 355-368, 2008
6172008
Polycomb repressive complex 2 is required for MLL-AF9 leukemia
T Neff, AU Sinha, MJ Kluk, N Zhu, MH Khattab, L Stein, H Xie, SH Orkin, ...
Proceedings of the National Academy of Sciences, 2012
2432012
DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia
CW Chen, RP Koche, AU Sinha, AJ Deshpande, N Zhu, R Eng, ...
Nature medicine 21 (4), 335-343, 2015
2302015
Cell of origin determines clinically relevant subtypes of MLL-rearranged AML.
AV Krivtsov, ME Figueroa, AU Sinha, MC Stubbs, Z Feng, PJ Valk, ...
Leukemia: official journal of the Leukemia Society of America, Leukemia …, 2012
2222012
Mutations in epigenetic regulators including SETD2 are gained during relapse in paediatric acute lymphoblastic leukaemia
BG Mar, LB Bullinger, KM McLean, PV Grauman, MH Harris, K Stevenson, ...
Nature communications 5 (1), 3469, 2014
2052014
Targeting Chromatin Regulators Inhibits Leukemogenic Gene Expression in NPM1 Mutant Leukemia
MWM Kühn, E Song, Z Feng, A Sinha, CW Chen, AJ Deshpande, ...
Cancer discovery 6 (10), 1166-1181, 2016
2032016
mTOR complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leukemogenesis
D Kalaitzidis, SM Sykes, Z Wang, N Punt, Y Tang, C Ragu, AU Sinha, ...
Cell stem cell 11 (3), 429-439, 2012
1972012
Cinteny: flexible analysis and visualization of synteny and genome rearrangements in multiple organisms
AU Sinha, J Meller
Bmc Bioinformatics 8 (1), 82, 2007
1822007
AF10 regulates progressive H3K79 methylation and HOX gene expression in diverse AML subtypes
AJ Deshpande, A Deshpande, AU Sinha, L Chen, J Chang, A Cihan, ...
Cancer cell 26 (6), 896-908, 2014
1812014
Leukemic transformation by the MLL-AF6 fusion oncogene requires the H3K79 methyltransferase Dot1l.
AJ Deshpande, L Chen, M Fazio, AU Sinha, KM Bernt, D Banka, S Dias, ...
Blood, 2013
1772013
Haploinsufficiency of Dnmt1 impairs leukemia stem cell function through derepression of bivalent chromatin domains
JJ Trowbridge, AU Sinha, N Zhu, M Li, SA Armstrong, SH Orkin
Genes & Development 26 (4), 344-349, 2012
1462012
NUP98 fusion proteins interact with the NSL and MLL1 complexes to drive leukemogenesis
H Xu, DG Valerio, ME Eisold, A Sinha, RP Koche, W Hu, CW Chen, ...
Cancer cell 30 (6), 863-878, 2016
1242016
KMT2C mediates the estrogen dependence of breast cancer through regulation of ERα enhancer function
K Gala, Q Li, A Sinha, P Razavi, M Dorso, F Sanchez-Vega, YR Chung, ...
Oncogene 37 (34), 4692-4710, 2018
1202018
MLL-AF9–and HOXA9-mediated acute myeloid leukemia stem cell self-renewal requires JMJD1C
N Zhu, M Chen, R Eng, J DeJong, AU Sinha, NF Rahnamay, R Koche, ...
The Journal of clinical investigation 126 (3), 997-1011, 2016
1032016
Splicing factor YBX1 mediates persistence of JAK2-mutated neoplasms
AK Jayavelu, TM Schnöder, F Perner, C Herzog, A Meiler, ...
Nature 588 (7836), 157-163, 2020
1012020
MLL1 and DOT1L cooperate with meningioma-1 to induce acute myeloid leukemia
SS Riedel, JN Haladyna, M Bezzant, B Stevens, DA Pollyea, AU Sinha, ...
The Journal of clinical investigation 126 (4), 1438-1450, 2016
622016
El sistema no puede realizar la operación en estos momentos. Inténtalo de nuevo más tarde.
Artículos 1–20