| A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage MJGW Ladds, IMM Van Leeuwen, CJ Drummond, S Chu, AR Healy, ... Nature communications 9 (1), 1107, 2018 | 87 | 2018 |
| Lipids shape the electron acceptor-binding site of the peripheral membrane protein dihydroorotate dehydrogenase J Costeira-Paulo, J Gault, G Popova, MJGW Ladds, IMM van Leeuwen, ... Cell chemical biology 25 (3), 309-317. e4, 2018 | 27 | 2018 |
| Optimization of tetrahydroindazoles as inhibitors of human dihydroorotate dehydrogenase and evaluation of their activity and in vitro metabolic stability G Popova, MJGW Ladds, L Johansson, A Saleh, J Larsson, L Sandberg, ... Journal of Medicinal Chemistry 63 (8), 3915-3934, 2020 | 16 | 2020 |
| Exploitation of dihydroorotate dehydrogenase (DHODH) and p53 activation as therapeutic targets: A case study in polypharmacology MJGW Ladds, G Popova, A Pastor-Fernández, S Kannan, ... Journal of Biological Chemistry 295 (52), 17935-17949, 2020 | 12 | 2020 |
| Autophagic flux blockage by accumulation of weakly basic tenovins leads to elimination of B-Raf mutant tumour cells that survive vemurafenib MJGW Ladds, A Pastor-Fernandez, G Popova, IMM van Leeuwen, ... Plos one 13 (4), e0195956, 2018 | 5 | 2018 |
| Publisher Correction: A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage (Nature Communications,(2018), 9, 1,(1107), 10.1038 … MJGW Ladds, IMM van Leeuwen, CJ Drummond, S Chu, AR Healy, ... Nature Communications 14 (1), 5019, 2023 | | 2023 |
| Reconstructing the regulatory programs underlying the phenotypic plasticity of neural cancers I Larsson, F Held, G Popova, A Koc, R Jörnsten, S Nelander bioRxiv, 2023.03. 10.532041, 2023 | | 2023 |
| Dihydroorotate Dehydrogenase: New Insights into an Old Target G Popova PQDT-Global, 2020 | | 2020 |
| Specificity for adenine is established during the hydrolytic cycle of poly (A)-specific ribonuclease (PARN): Mechanism for poly (A) selectivity by PARN N Nissbeck, N Henriksson, P Nilsson, J Berndtsson, G Popova, A Virtanen | | 2019 |
Marcus LaddsAstraZenecaVerified email at astrazeneca.com
