| ProtGPT2 is a deep unsupervised language model for protein design N Ferruz, S Schmidt, B Höcker Nature communications 13 (1), 4348, 2022 | 274 | 2022 |
| De novo design of a four-fold symmetric TIM-barrel protein with atomic-level accuracy PS Huang, K Feldmeier, F Parmeggiani, DA Fernandez Velasco, ... Nature chemical biology 12 (1), 29-34, 2016 | 274 | 2016 |
| Oxygen-Insensitive Nitroreductases: Analysis of the Roles ofnfsA and nfsB in Development of Resistance to 5-Nitrofuran Derivatives in Escherichia coli J Whiteway, P Koziarz, J Veall, N Sandhu, P Kumar, B Hoecher, ... Journal of bacteriology 180 (21), 5529-5539, 1998 | 272 | 1998 |
| Catalytic Versatility, Stability, and Evolution of the (βα)8-Barrel Enzyme Fold R Sterner, B Höcker Chemical Reviews 105 (11), 4038-4055, 2005 | 246 | 2005 |
| Dissection of a (βα) 8-barrel enzyme into two folded halves B Höcker, S Beismann-Driemeyer, S Hettwer, A Lustig, R Sterner Nature structural biology 8 (1), 32-36, 2001 | 190 | 2001 |
| Mimicking enzyme evolution by generating new (βα) 8-barrels from (βα) 4-half-barrels B Höcker, J Claren, R Sterner Proceedings of the National Academy of Sciences 101 (47), 16448-16453, 2004 | 134 | 2004 |
| Stability, catalytic versatility and evolution of the (βα)8-barrel fold B Höcker, C Jürgens, M Wilmanns, R Sterner Current opinion in biotechnology 12 (4), 376-381, 2001 | 126 | 2001 |
| Computational design of ligand binding is not a solved problem B Schreier, C Stumpp, S Wiesner, B Höcker Proceedings of the National Academy of Sciences 106 (44), 18491-18496, 2009 | 112 | 2009 |
| Controllable protein design with language models N Ferruz, B Höcker Nature Machine Intelligence 4 (6), 521-532, 2022 | 108 | 2022 |
| A biosensor for the direct visualization of auxin O Herud-Sikimić, AC Stiel, M Kolb, S Shanmugaratnam, KW Berendzen, ... Nature 592 (7856), 768-772, 2021 | 106 | 2021 |
| A robust protein host for anchoring chelating ligands and organocatalysts MT Reetz, M Rentzsch, A Pletsch, A Taglieber, F Hollmann, ... ChemBioChem 9 (4), 552-564, 2008 | 93 | 2008 |
| Establishing wild-type levels of catalytic activity on natural and artificial (βα) 8-barrel protein scaffolds J Claren, C Malisi, B Höcker, R Sterner Proceedings of the National Academy of Sciences 106 (10), 3704-3709, 2009 | 84 | 2009 |
| Divergent Evolution of (??) 8-Barrel Enzymes M Henn-Sax, B Höcker, M Wilmanns, R Sterner Walter de Gruyter 382 (9), 1315-1320, 2001 | 82 | 2001 |
| A βα-barrel built by the combination of fragments from different folds TAM Bharat, S Eisenbeis, K Zeth, B Höcker Proceedings of the National Academy of Sciences 105 (29), 9942-9947, 2008 | 76 | 2008 |
| Evolutionary relationship of two ancient protein superfolds JA Farías-Rico, S Schmidt, B Höcker Nature chemical biology 10 (9), 710-715, 2014 | 73 | 2014 |
| A common evolutionary origin of two elementary enzyme folds B Höcker, S Schmidt, R Sterner FEBS letters 510 (3), 133-135, 2002 | 68 | 2002 |
| Automated scaffold selection for enzyme design C Malisi, O Kohlbacher, B Höcker Proteins: Structure, Function, and Bioinformatics 77 (1), 74-83, 2009 | 63 | 2009 |
| Structure‐based design of robust glucose biosensors using a Thermotoga maritima periplasmic glucose‐binding protein Y Tian, MJ Cuneo, A Changela, B Höcker, LS Beese, HW Hellinga Protein science 16 (10), 2240-2250, 2007 | 61 | 2007 |
| Potential of fragment recombination for rational design of proteins S Eisenbeis, W Proffitt, M Coles, V Truffault, S Shanmugaratnam, J Meiler, ... Journal of the American Chemical Society 134 (9), 4019-4022, 2012 | 59 | 2012 |
| Molecular engineering of organophosphate hydrolysis activity from a weak promiscuous lactonase template MM Meier, C Rajendran, C Malisi, NG Fox, C Xu, S Schlee, ... Journal of the American Chemical Society 135 (31), 11670-11677, 2013 | 58 | 2013 |
