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Mr Louis Y Luk
Mr Louis Y Luk
University Research Fellow
Dirección de correo verificada de cardiff.ac.uk - Página principal
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Cell-penetrating peptide sequence and modification dependent uptake and subcellular distribution of green florescent protein in different cell lines
SG Patel, EJ Sayers, L He, R Narayan, TL Williams, EM Mills, ...
Scientific reports 9 (1), 6298, 2019
2042019
Unraveling the role of protein dynamics in dihydrofolate reductase catalysis
LYP Luk, J Javier Ruiz-Pernia, WM Dawson, M Roca, EJ Loveridge, ...
Proceedings of the National Academy of Sciences 110 (41), 16344-16349, 2013
1442013
Mechanistic studies on norcoclaurine synthase of benzylisoquinoline alkaloid biosynthesis: an enzymatic Pictet− Spengler reaction
LYP Luk, S Bunn, DK Liscombe, PJ Facchini, ME Tanner
Biochemistry 46 (35), 10153-10161, 2007
1442007
A cope rearrangement in the reaction catalyzed by dimethylallyltryptophan synthase?
LYP Luk, Q Qian, ME Tanner
Journal of the American Chemical Society 133 (32), 12342-12345, 2011
922011
Using genetically incorporated unnatural amino acids to control protein functions in mammalian cells
AR Nödling, LA Spear, TL Williams, LYP Luk, YH Tsai
Essays in biochemistry 63 (2), 237-266, 2019
912019
Mechanism of dimethylallyltryptophan synthase: evidence for a dimethylallyl cation intermediate in an aromatic prenyltransferase reaction
LYP Luk, ME Tanner
Journal of the American Chemical Society 131 (39), 13932-13933, 2009
862009
Increased Dynamic Effects in a Catalytically Compromised Variant of Escherichia coli Dihydrofolate Reductase
JJ Ruiz-Pernia, LYP Luk, R García-Meseguer, S Martí, EJ Loveridge, ...
Journal of the American Chemical Society 135 (49), 18689-18696, 2013
692013
Condensation of 2-((alkylthio)(aryl) methylene) malononitrile with 1, 2-aminothiol as a novel bioorthogonal reaction for site-specific protein modification and peptide cyclization
X Zheng, Z Li, W Gao, X Meng, X Li, LYP Luk, Y Zhao, YH Tsai, C Wu
Journal of the American Chemical Society 142 (11), 5097-5103, 2020
552020
Protein motions and dynamic effects in enzyme catalysis
LYP Luk, EJ Loveridge, RK Allemann
Physical Chemistry Chemical Physics 17 (46), 30817-30827, 2015
532015
Comparative biological evaluation and G-quadruplex interaction studies of two new families of organometallic gold (I) complexes featuring N-heterocyclic carbene and alkynyl ligands
SM Meier-Menches, B Aikman, D Döllerer, WT Klooster, SJ Coles, N Santi, ...
Journal of Inorganic Biochemistry 202, 110844, 2020
452020
Cyanine dye mediated mitochondrial targeting enhances the anti-cancer activity of small-molecule cargoes
AR Nödling, EM Mills, X Li, D Cardella, EJ Sayers, SH Wu, AT Jones, ...
Chemical communications 56 (34), 4672-4675, 2020
432020
Use of an asparaginyl endopeptidase for chemo-enzymatic peptide and protein labeling
TMS Tang, D Cardella, AJ Lander, X Li, JS Escudero, YH Tsai, LYP Luk
Chemical science 11 (23), 5881-5888, 2020
422020
Reactivity and selectivity of iminium organocatalysis improved by a protein host
AR Nödling, K Świderek, R Castillo, JW Hall, A Angelastro, LC Morrill, ...
Angewandte Chemie 130 (38), 12658-12662, 2018
422018
Approaches for peptide and protein cyclisation
HC Hayes, LYP Luk, YH Tsai
Organic & biomolecular chemistry 19 (18), 3983-4001, 2021
412021
Chemical ligation and isotope labeling to locate dynamic effects during catalysis by dihydrofolate reductase
LYP Luk, JJ Ruiz‐Pernía, AS Adesina, EJ Loveridge, I Tuñón, V Moliner, ...
Angewandte Chemie 127 (31), 9144-9148, 2015
402015
Protein Isotope Effects in Dihydrofolate Reductase From Geobacillus stearothermophilus Show Entropic–Enthalpic Compensatory Effects on the Rate Constant
LYP Luk, JJ Ruiz-Pernía, WM Dawson, EJ Loveridge, I Tuñón, V Moliner, ...
Journal of the American Chemical Society 136 (49), 17317-17323, 2014
382014
A Versatile Disulfide-Driven Recycling System for NADP+ with High Cofactor Turnover Number
A Angelastro, WM Dawson, LYP Luk, RK Allemann
ACS Catalysis 7 (2), 1025-1029, 2017
342017
Different dynamical effects in mesophilic and hyperthermophilic dihydrofolate reductases
LYP Luk, EJ Loveridge, RK Allemann
Journal of the American Chemical Society 136 (19), 6862-6865, 2014
312014
Minimization of dynamic effects in the evolution of dihydrofolate reductase
JJ Ruiz-Pernía, E Behiry, LYP Luk, EJ Loveridge, I Tunón, V Moliner, ...
Chemical Science 7 (5), 3248-3255, 2016
282016
Thermal Adaptation of Dihydrofolate Reductase from the Moderate Thermophile Geobacillus stearothermophilus
J Guo, LYP Luk, EJ Loveridge, RK Allemann
Biochemistry 53 (17), 2855-2863, 2014
272014
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Artículos 1–20