Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss M Talantova, S Sanz-Blasco, X Zhang, P Xia, MW Akhtar, S Okamoto, ... Proceedings of the National Academy of Sciences 110 (27), E2518-E2527, 2013 | 635 | 2013 |
Isogenic human iPSC Parkinson’s model shows nitrosative stress-induced dysfunction in MEF2-PGC1α transcription SD Ryan, N Dolatabadi, SF Chan, X Zhang, MW Akhtar, J Parker, ... Cell 155 (6), 1351-1364, 2013 | 481 | 2013 |
Aberrant protein s-nitrosylation in neurodegenerative diseases T Nakamura, S Tu, MW Akhtar, CR Sunico, S Okamoto, SA Lipton Neuron 78 (4), 596-614, 2013 | 369 | 2013 |
An essential role for histone deacetylase 4 in synaptic plasticity and memory formation MS Kim, MW Akhtar, M Adachi, M Mahgoub, R Bassel-Duby, ET Kavalali, ... Journal of Neuroscience 32 (32), 10879-10886, 2012 | 261 | 2012 |
Histone deacetylases 1 and 2 form a developmental switch that controls excitatory synapse maturation and function MW Akhtar, J Raingo, ED Nelson, RL Montgomery, EN Olson, ET Kavalali, ... Journal of Neuroscience 29 (25), 8288-8297, 2009 | 181 | 2009 |
Aberrant protein S-nitrosylation contributes to the pathophysiology of neurodegenerative diseases T Nakamura, OA Prikhodko, E Pirie, S Nagar, MW Akhtar, CK Oh, ... Neurobiology of disease 84, 99-108, 2015 | 154 | 2015 |
In vivo analysis of MEF2 transcription factors in synapse regulation and neuronal survival MW Akhtar, MS Kim, M Adachi, MJ Morris, X Qi, JA Richardson, ... PloS one 7 (4), e34863, 2012 | 143 | 2012 |
Elevated glucose and oligomeric β-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation MW Akhtar, S Sanz-Blasco, N Dolatabadi, J Parker, K Chon, MS Lee, ... Nature Communications 7 (10242), 2016 | 119 | 2016 |
NitroSynapsin therapy for a mouse MEF2C haploinsufficiency model of human autism S Tu, MW Akhtar, RM Escorihuela, A Amador-Arjona, V Swarup, J Parker, ... Nature communications 8 (1), 1488, 2017 | 88 | 2017 |
α-Synuclein oligomers induce glutamate release from astrocytes and excessive extrasynaptic NMDAR activity in neurons, thus contributing to synapse loss D Trudler, S Sanz-Blasco, YS Eisele, S Ghatak, K Bodhinathan, ... Journal of Neuroscience 41 (10), 2264-2273, 2021 | 72 | 2021 |
Differential effects of synaptic and extrasynaptic NMDA receptors on Aβ-induced nitric oxide production in cerebrocortical neurons E Molokanova, MW Akhtar, S Sanz-Blasco, T Nakamura, SI Okamoto, ... Biophysical Journal 106 (2), 152a, 2014 | 71 | 2014 |
Redox regulation of protein function via cysteine S-nitrosylation and its relevance to neurodegenerative diseases MW Akhtar, CR Sunico, T Nakamura, SA Lipton International journal of cell biology 2012, 2012 | 61 | 2012 |
Oligomeric Hsp33 with enhanced chaperone activity: gel filtration, cross-linking, and small angle x-ray scattering (SAXS) analysis MW Akhtar, V Srinivas, B Raman, T Ramakrishna, T Inobe, K Maki, M Arai, ... Journal of Biological Chemistry 279 (53), 55760-55769, 2004 | 31 | 2004 |
ATM-dependent phosphorylation of MEF2D promotes neuronal survival after DNA damage SF Chan, S Sances, LM Brill, S Okamoto, R Zaidi, SR McKercher, ... Journal of Neuroscience 34 (13), 4640-4653, 2014 | 27 | 2014 |
Combating oxidative/nitrosative stress with electrophilic counterattack strategies T Satoh, MW Akhtar, SA Lipton Oxidative stress and redox regulation, 277-307, 2013 | 9 | 2013 |
Effect of sparfloxacin and terfenadine combination on QT-intervals at various RR-intervals M AKHTAR, N Saha, A Roy, KK Pillai Indian journal of pharmacology 34 (4), 264-268, 2002 | 3 | 2002 |
Ozanimod (RPC1063) is potentially neuroprotective through direct CNS effects KR Meadows, JV Selkirk, MW Akhtar, C Hutton, GJ Opiteck, FL Scott MULTIPLE SCLEROSIS JOURNAL 23, 624-624, 2017 | 2 | 2017 |
Ozanimod (RPC1063) Potentially Confers Neuroprotective Benefit through Modulation of S1P1R on Astrocytes KRT Meadows, MW Akhtar, C Villescaz, B Clemons, C Lopez, ... ACTRIMS Forum 2018, 2018 | 1 | 2018 |
Ozanimod (RPC1063) Preserves Central Nervous System (CNS) Tissue in Rodents by Reducing Neuronal Breaks in Vivo and Modulating Astrocyte Activity in Vitro (P5. 027) KT Meadows, MW Akhtar, M Brand, C Villescaz, B Clemons, C Lopez, ... Neurology 90 (15 Supplement), 2018 | | 2018 |
THE Surgeon Journal ofthe Royal Colleges of Edinburgh and Ireland, Volume P Chandran, PN Haray, A Chaudhuri, J Harty, R Ackroyd, SP Chew, ... | | 2003 |