Clotilde Lagier-Tourenne
Clotilde Lagier-Tourenne
Massachusetts General Hospital and Harvard Medical School
Dirección de correo verificada de ucsd.edu
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Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43
M Polymenidou, C Lagier-Tourenne, KR Hutt, SC Huelga, J Moran, ...
Nature neuroscience 14 (4), 459-468, 2011
9352011
TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration
C Lagier-Tourenne, M Polymenidou, DW Cleveland
Human molecular genetics 19 (R1), R46-R64, 2010
8742010
Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways
ET Cirulli, BN Lasseigne, S Petrovski, PC Sapp, PA Dion, CS Leblond, ...
Science 347 (6229), 1436-1441, 2015
6102015
Rethinking als: The fus about tdp-43
C Lagier-Tourenne, DW Cleveland
Cell 136 (6), 1001-1004, 2009
5792009
Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs
C Lagier-Tourenne, M Polymenidou, KR Hutt, AQ Vu, M Baughn, ...
Nature neuroscience 15 (11), 1488, 2012
5302012
Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degeneration
C Lagier-Tourenne, M Baughn, F Rigo, S Sun, P Liu, HR Li, J Jiang, ...
Proceedings of the National Academy of Sciences 110 (47), E4530-E4539, 2013
4422013
ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS
SC Ling, CP Albuquerque, JS Han, C Lagier-Tourenne, S Tokunaga, ...
Proceedings of the National Academy of Sciences 107 (30), 13318-13323, 2010
3842010
ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43
ES Arnold, SC Ling, SC Huelga, C Lagier-Tourenne, M Polymenidou, ...
Proceedings of the National Academy of Sciences 110 (8), E736-E745, 2013
2912013
Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs
J Jiang, Q Zhu, TF Gendron, S Saberi, M McAlonis-Downes, A Seelman, ...
Neuron 90 (3), 535-550, 2016
2892016
ADCK3, an ancestral kinase, is mutated in a form of recessive ataxia associated with coenzyme Q10 deficiency
C Lagier-Tourenne, M Tazir, LC López, CM Quinzii, M Assoum, N Drouot, ...
The American Journal of Human Genetics 82 (3), 661-672, 2008
2672008
Homozygous mutation in SPATA16 is associated with male infertility in human globozoospermia
AHDM Dam, I Koscinski, JAM Kremer, C Moutou, AS Jaeger, ...
The American Journal of Human Genetics 81 (4), 813-820, 2007
2512007
Direct conversion of patient fibroblasts demonstrates non-cell autonomous toxicity of astrocytes to motor neurons in familial and sporadic ALS
K Meyer, L Ferraiuolo, CJ Miranda, S Likhite, S McElroy, S Renusch, ...
Proceedings of the National Academy of Sciences 111 (2), 829-832, 2014
2322014
The gene disrupted in Marinesco-Sjögren syndrome encodes SIL1, an HSPA5 cochaperone
AK Anttonen, I Mahjneh, RH Hämäläinen, C Lagier-Tourenne, O Kopra, ...
Nature genetics 37 (12), 1309-1311, 2005
2142005
Mutant Huntingtin promotes autonomous microglia activation via myeloid lineage-determining factors
A Crotti, C Benner, BE Kerman, D Gosselin, C Lagier-Tourenne, ...
Nature neuroscience 17 (4), 513-521, 2014
2092014
C9ORF72 poly (GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins
YJ Zhang, TF Gendron, JC Grima, H Sasaguri, K Jansen-West, YF Xu, ...
Nature neuroscience 19 (5), 668-677, 2016
1652016
ALS-causative mutations in FUS/TLS confer gain and loss of function by altered association with SMN and U1-snRNP
S Sun, SC Ling, J Qiu, CP Albuquerque, Y Zhou, S Tokunaga, H Li, H Qiu, ...
Nature communications 6 (1), 1-14, 2015
1612015
Misregulated RNA processing in amyotrophic lateral sclerosis
M Polymenidou, C Lagier-Tourenne, KR Hutt, CF Bennett, DW Cleveland, ...
Brain research 1462, 3-15, 2012
1522012
Nuclear-import receptors reverse aberrant phase transitions of RNA-binding proteins with prion-like domains
L Guo, HJ Kim, H Wang, J Monaghan, F Freyermuth, JC Sung, ...
Cell 173 (3), 677-692. e20, 2018
1332018
Reactive oxygen species, oxidative stress, and cell death correlate with level of CoQ10 deficiency
CM Quinzii, LC López, RW Gilkerson, B Dorado, J Coku, AB Naini, ...
The FASEB journal 24 (10), 3733-3743, 2010
1322010
Variant CCG and GGC repeats within the CTG expansion dramatically modify mutational dynamics and likely contribute toward unusual symptoms in some myotonic dystrophy type 1 …
C Braida, RKA Stefanatos, B Adam, N Mahajan, HJM Smeets, F Niel, ...
Human molecular genetics 19 (8), 1399-1412, 2010
1252010
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