Simon Dujardin, PhD
Simon Dujardin, PhD
Instructor in Neurology, Massachusetts General Hospital, Harvard Medical School
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Tau protein liquid–liquid phase separation can initiate tau aggregation
S Wegmann, B Eftekharzadeh, K Tepper, KM Zoltowska, RE Bennett, ...
The EMBO journal 37 (7), e98049, 2018
What is the evidence that tau pathology spreads through prion-like propagation?
A Mudher, M Colin, S Dujardin, M Medina, I Dewachter, SM Alavi Naini, ...
Acta neuropathologica communications 5 (1), 1-20, 2017
Tau protein disrupts nucleocytoplasmic transport in Alzheimer’s disease
B Eftekharzadeh, JG Daigle, LE Kapinos, A Coyne, J Schiantarelli, ...
Neuron 99 (5), 925-940. e7, 2018
Tau impairs neural circuits, dominating amyloid-β effects, in Alzheimer models in vivo
MA Busche, S Wegmann, S Dujardin, C Commins, J Schiantarelli, ...
Nature neuroscience 22 (1), 57-64, 2019
Neuron-to-neuron wild-type Tau protein transfer through a trans-synaptic mechanism: relevance to sporadic tauopathies
S Dujardin, K Lécolle, R Caillierez, S Bégard, N Zommer, C Lachaud, ...
Acta neuropathologica communications 2 (1), 1-14, 2014
Tunneling nanotube (TNT)-mediated neuron-to neuron transfer of pathological Tau protein assemblies
M Tardivel, S Bégard, L Bousset, S Dujardin, A Coens, R Melki, L Buée, ...
Acta neuropathologica communications 4 (1), 1-14, 2016
Tau PTM profiles identify patient heterogeneity and stages of Alzheimer’s disease
H Wesseling, W Mair, M Kumar, CN Schlaffner, S Tang, P Beerepoot, ...
Cell 183 (6), 1699-1713. e13, 2020
Tau molecular diversity contributes to clinical heterogeneity in Alzheimer’s disease
S Dujardin, C Commins, A Lathuiliere, P Beerepoot, AR Fernandes, ...
Nature medicine 26 (8), 1256-1263, 2020
Ectosomes: a new mechanism for non-exosomal secretion of tau protein
S Dujardin, S Bégard, R Caillierez, C Lachaud, L Delattre, S Carrier, ...
PloS one 9 (6), e100760, 2014
CBL, CBLB, TET2, ASXL1, and IDH1/2 mutations and additional chromosomal aberrations constitute molecular events in chronic myelogenous leukemia
H Makishima, AM Jankowska, MA McDevitt, C O'Keefe, S Dujardin, ...
Blood, The Journal of the American Society of Hematology 117 (21), e198-e206, 2011
Enhanced tau aggregation in the presence of amyloid β
RE Bennett, SL DeVos, S Dujardin, B Corjuc, R Gor, J Gonzalez, AD Roe, ...
The American journal of pathology 187 (7), 1601-1612, 2017
From the prion-like propagation hypothesis to therapeutic strategies of anti-tau immunotherapy
M Colin, S Dujardin, S Schraen-Maschke, G Meno-Tetang, C Duyckaerts, ...
Acta neuropathologica 139 (1), 3-25, 2020
Tau reduction in the presence of amyloid-β prevents tau pathology and neuronal death in vivo
SL DeVos, BT Corjuc, C Commins, S Dujardin, RN Bannon, D Corjuc, ...
Brain 141 (7), 2194-2212, 2018
Different tau species lead to heterogeneous tau pathology propagation and misfolding
S Dujardin, S Bégard, R Caillierez, C Lachaud, S Carrier, S Lieger, ...
Acta neuropathologica communications 6 (1), 1-12, 2018
Selection of an efficient AAV vector for robust CNS transgene expression
KS Hanlon, JC Meltzer, T Buzhdygan, MJ Cheng, M Sena-Esteves, ...
Molecular Therapy-Methods & Clinical Development 15, 320-332, 2019
Invited review: animal models of tauopathies and their implications for research/translation into the clinic
S Dujardin, M Colin, L Buée
Neuropathology and applied neurobiology 41 (1), 59-80, 2015
Lentiviral delivery of the human wild-type tau protein mediates a slow and progressive neurodegenerative tau pathology in the rat brain
R Caillierez, S Bégard, K Lécolle, V Deramecourt, N Zommer, S Dujardin, ...
Molecular Therapy 21 (7), 1358-1368, 2013
Clinical, neuropathological, and biochemical characterization of the novel tau mutation P332S
V Deramecourt, F Lebert, CA Maurage, FJ Fernandez-Gomez, S Dujardin, ...
Journal of Alzheimer's Disease 31 (4), 741-749, 2012
Tau prion-like propagation: state of the art and current challenges
S Dujardin, BT Hyman
Tau Biology, 305-325, 2019
In vivo detection of tau fibrils and amyloid β aggregates with luminescent conjugated oligothiophenes and multiphoton microscopy
M Calvo-Rodriguez, SS Hou, AC Snyder, S Dujardin, H Shirani, ...
Acta neuropathologica communications 7 (1), 1-10, 2019
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