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Kate Megquier
Kate Megquier
Postdoctoral Associate, Broad Institute
Dirección de correo verificada de broadinstitute.org
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Ancestry-inclusive dog genomics challenges popular breed stereotypes
K Morrill, J Hekman, X Li, J McClure, B Logan, L Goodman, M Gao, ...
Science 376 (6592), eabk0639, 2022
1082022
Comparative genomics reveals shared mutational landscape in canine hemangiosarcoma and human angiosarcoma
K Megquier, J Turner-Maier, R Swofford, JH Kim, AL Sarver, C Wang, ...
Molecular Cancer Research 17 (12), 2410-2421, 2019
872019
Genome-wide association study identifies shared risk loci common to two malignancies in golden retrievers
N Tonomura, I Elvers, R Thomas, K Megquier, J Turner-Maier, C Howald, ...
PLoS genetics 11 (2), e1004922, 2015
872015
Molecular biology and evolution of cancer: from discovery to action
JA Somarelli, H Gardner, VL Cannataro, EF Gunady, AM Boddy, ...
Molecular biology and evolution 37 (2), 320-326, 2020
702020
Genome-wide association study of golden retrievers identifies germ-line risk factors predisposing to mast cell tumours
ML Arendt, M Melin, N Tonomura, M Koltookian, C Courtay-Cahen, ...
PLoS genetics 11 (11), e1005647, 2015
582015
Variants within the SP110 nuclear body protein modify risk of canine degenerative myelopathy
EL Ivansson, K Megquier, SV Kozyrev, E Murén, IB Körberg, R Swofford, ...
Proceedings of the National Academy of Sciences 113 (22), E3091-E3100, 2016
512016
BarkBase: epigenomic annotation of canine genomes
K Megquier, DP Genereux, J Hekman, R Swofford, J Turner-Maier, ...
Genes 10 (6), 433, 2019
302019
Improving cancer drug discovery by studying cancer across the tree of life
JA Somarelli, AM Boddy, HL Gardner, SB DeWitt, J Tuohy, K Megquier, ...
Molecular Biology and Evolution 37 (1), 11-17, 2020
252020
Genomically complex human angiosarcoma and canine hemangiosarcoma establish convergent angiogenic transcriptional programs driven by novel gene fusions
JH Kim, K Megquier, R Thomas, AL Sarver, JM Song, YT Kim, N Cheng, ...
Molecular Cancer Research 19 (5), 847-861, 2021
202021
Genome-Wide Analyses for Osteosarcoma in Leonberger Dogs Reveal the CDKN2A/B Gene Locus as a Major Risk Locus
A Letko, KM Minor, EM Norton, VD Marinescu, M Drögemüller, E Ivansson, ...
Genes 12 (12), 1964, 2021
152021
Lifetime prevalence of malignant and benign tumours in companion dogs: Cross‐sectional analysis of Dog Aging Project baseline survey
SM Schwartz, SR Urfer, M White, K Megquier, S Shrager, ...
Veterinary and comparative oncology 20 (4), 797-804, 2022
102022
Shared hotspot mutations in oncogenes position dogs as an unparalleled comparative model for precision therapeutics
L Rodrigues, J Watson, Y Feng, B Lewis, G Harvey, G Post, K Megquier, ...
Scientific Reports 13 (1), 10935, 2023
92023
Ancestry-inclusive dog genomics challenges popular breed stereotypes. Science 376, eabk0639
K Morrill, J Hekman, X Li, J McClure, B Logan, L Goodman, M Gao, ...
92022
The genomic landscape of canine osteosarcoma cell lines reveals conserved structural complexity and pathway alterations
K Megquier, J Turner-Maier, K Morrill, X Li, J Johnson, EK Karlsson, ...
Plos one 17 (9), e0274383, 2022
62022
Shared hotspot mutations in spontaneously arising cancers position dog as an unparalleled comparative model for precision therapeutics
L Rodrigues, J Watson, Y Feng, B Lewis, G Harvey, G Post, K Megquier, ...
bioRxiv, 2021.10. 22.465469, 2021
42021
Identification of genomic alterations with clinical impact in canine splenic hemangiosarcoma
T Estabrooks, A Gurinovich, J Pietruska, B Lewis, G Harvey, G Post, ...
Veterinary and Comparative Oncology 21 (4), 623-633, 2023
32023
Molecular mechanisms that activate convergent oncogenic pathway in genomically complex angiosarcoma
JH Kim, K Megquier, AL Sarver, R Thomas, AJ Schulte, C Wang, I Elvers, ...
Cancer Research 80 (16_Supplement), 195-195, 2020
2020
Advancing blood biopsy through the canine comparative model
K Megquier, K Xiong, HL Gardner, J Rhoades, V Adalsteinsson, ...
CLINICAL CANCER RESEARCH 26 (11), 64-65, 2020
2020
Abstract A58: Advancing blood biopsy through the canine comparative model
K Megquier, K Xiong, HL Gardner, J Rhoades, V Adalsteinsson, ...
Clinical Cancer Research 26 (11_Supplement), A58-A58, 2020
2020
BarkBase
K Megquier, DP Genereux, J Hekman, R Swofford, J Turner-Maier, ...
2019
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Artículos 1–20