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Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the µ-opioid-receptor gene
HWD Matthes, R Maldonado, F Simonin, O Valverde, S Slowe, I Kitchen, ...
Nature 383 (6603), 819-823, 1996
Mice deficient for δ-and μ-opioid receptors exhibit opposing alterations of emotional responses
D Filliol, S Ghozland, J Chluba, M Martin, HWD Matthes, F Simonin, ...
Nature genetics 25 (2), 195-200, 2000
Involvement of the endocannabinoid system in drug addiction
R Maldonado, O Valverde, F Berrendero
Trends in neurosciences 29 (4), 225-232, 2006
Involvement of the extracellular signal-regulated kinase cascade for cocaine-rewarding properties
E Valjent, JC Corvol, C Pagès, MJ Besson, R Maldonado, J Caboche
Journal of Neuroscience 20 (23), 8701-8709, 2000
Absence of opiate rewarding effects in mice lacking dopamine D2 receptors
R Maldonado, A Saiardi, O Valverde, TA Samad, BP Roques, E Borrelli
Nature 388 (6642), 586-589, 1997
Knockout of ERK1 MAP kinase enhances synaptic plasticity in the striatum and facilitates striatal-mediated learning and memory
C Mazzucchelli, C Vantaggiato, A Ciamei, S Fasano, P Pakhotin, ...
Neuron 34 (5), 807-820, 2002
Involvement of CB1 cannabinoid receptors in emotional behaviour
M Martin, C Ledent, M Parmentier, R Maldonado, O Valverde
Psychopharmacology 159 (4), 379-387, 2002
Neural substrates of opiate withdrawal
GF Koob, R Maldonado, L Stinus
Trends in neurosciences 15 (5), 186-191, 1992
Disruption of the κ‐opioid receptor gene in mice enhances sensitivity to chemical visceral pain, impairs pharmacological actions of the selective κ‐agonist U‐50,488 H and …
F Simonin, O Valverde, C Smadja, S Slowe, I Kitchen, A Dierich, ...
The EMBO journal 17 (4), 886-897, 1998
Role of different brain structures in the expression of the physical morphine withdrawal syndrome.
R Maldonado, L Stinus, LH Gold, GF Koob
Journal of Pharmacology and Experimental Therapeutics 261 (2), 669-677, 1992
Functional interaction between opioid and cannabinoid receptors in drug self-administration
M Navarro, MRA Carrera, W Fratta, O Valverde, G Cossu, L Fattore, ...
Journal of Neuroscience 21 (14), 5344-5350, 2001
Cannabinoid modulation of hippocampal long-term memory is mediated by mTOR signaling
E Puighermanal, G Marsicano, A Busquets-Garcia, B Lutz, R Maldonado, ...
Nature neuroscience 12 (9), 1152-1158, 2009
Reduction of morphine abstinence in mice with a mutation in the gene encoding CREB
R Maldonado, JA Blendy, E Tzavara, P Gass, BP Roques, J Hanoune, ...
Science 273 (5275), 657-659, 1996
Human N-methyl D-aspartate receptor antibodies alter memory and behaviour in mice
J Planagumà, F Leypoldt, F Mannara, J Gutiérrez-Cuesta, E Martín-García, ...
Brain 138 (1), 94-109, 2015
Behavioural and biochemical evidence for interactions between Δ9‐tetrahydrocannabinol and nicotine
E Valjent, JM Mitchell, MJ Besson, J Caboche, R Maldonado
British journal of pharmacology 135 (2), 564-578, 2002
The endocannabinoid system in guarding against fear, anxiety and stress
B Lutz, G Marsicano, R Maldonado, CJ Hillard
Nature Reviews Neuroscience 16 (12), 705-718, 2015
Motivational effects of cannabinoids are mediated by μ-opioid and κ-opioid receptors
S Ghozland, HWD Matthes, F Simonin, D Filliol, BL Kieffer, R Maldonado
Journal of Neuroscience 22 (3), 1146-1154, 2002
Differential role of anandamide and 2-arachidonoylglycerol in memory and anxiety-like responses
A Busquets-Garcia, E Puighermanal, A Pastor, R De La Torre, ...
Biological psychiatry 70 (5), 479-486, 2011
Involvement of the opioid system in the anxiolytic-like effects induced by Δ 9-tetrahydrocannabinol
F Berrendero, R Maldonado
Psychopharmacology 163 (1), 111-117, 2002
Lack of CB1 cannabinoid receptors modifies nicotine behavioural responses, but not nicotine abstinence
A Castañé, E Valjent, C Ledent, M Parmentier, R Maldonado, O Valverde
Neuropharmacology 43 (5), 857-867, 2002
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