Rainer Wilcken

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Frank M. BoecklerUniv. Professor, Lab for Molecular Design & Pharm. Biophysics, Eberhard Karls University TuebingenDirección de correo verificada de uni-tuebingen.de
Andreas C. JoergerStructural Genomics Consortium (SGC), Institute of Pharmaceutical Chemistry, Goethe UniversityDirección de correo verificada de pharmchem.uni-frankfurt.de
Markus Oliver ZimmermannUniversity of TuebingenDirección de correo verificada de uni-tuebingen.de
Alan FershtEmeritus Group Leader, MRC Laboratory of Molecular Biology, University of CambridgeDirección de correo verificada de cam.ac.uk
Andreas LangeUniversity of MuensterDirección de correo verificada de uni-muenster.de
Matthias R. BauerNovartis Institutes for BioMedical ResearchDirección de correo verificada de novartis.com
John SpencerChemistry, University of SussexDirección de correo verificada de sussex.ac.uk
Xiangrui LiuZhejiang UniversityDirección de correo verificada de zju.edu.cn
Dr. Stefan Zahnresearch group leader, Leibniz Institute of Surface EngineeringDirección de correo verificada de iom-leipzig.de
Anikó UdvarhelyiNovartis PharmaDirección de correo verificada de novartis.com
Matthias BaudUniversity of SouthamptonDirección de correo verificada de soton.ac.uk
GuoZhen WangUniversity of CambridgeDirección de correo verificada de cam.ac.uk
simona cotestaNovartis Institute of Biomedical researchDirección de correo verificada de novartis.com
Christopher M JohnsonMRC Laboratory of Molecular BiologyDirección de correo verificada de mrc-lmb.cam.ac.uk
Stephen McLaughlinMRC Laboratory of Molecular BiologyDirección de correo verificada de mrc-lmb.cam.ac.uk
Dmitry VeprintsevProfessor of Molecular and Cellular Pharmacology, University of NottinghamDirección de correo verificada de nottingham.ac.uk
Simon M. VogelBayer Pharma AGDirección de correo verificada de bayer.com
Ashraf AbadiProfessor, Former Dean, Faculty of Pharmacy and Biotechnology, German University in CairoDirección de correo verificada de guc.edu.eg
Gary Anthony PiazzaEndowed Professor and Department HeadDirección de correo verificada de auburn.edu
Heather N TinsleyUniversity of MontevalloDirección de correo verificada de montevallo.edu

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Rainer Wilcken

Flare Therapeutics

Dirección de correo verificada de flaretx.com

Computer-aided drug design Quantum Chemistry Solvation Computational Medicinal Chemistry Drug Discovery


Título Ordenar por citas Ordenar por año Ordenar por título	Citado por Citado por	Año
Principles and applications of halogen bonding in medicinal chemistry and chemical biology R Wilcken, MO Zimmermann, A Lange, AC Joerger, FM Boeckler Journal of medicinal chemistry 56 (4), 1363-1388, 2013	1183	2013
Halogen-enriched fragment libraries as leads for drug rescue of mutant p53 R Wilcken, X Liu, MO Zimmermann, TJ Rutherford, AR Fersht, AC Joerger, ... Journal of the American Chemical Society 134 (15), 6810-6818, 2012	244	2012
Small molecule induced reactivation of mutant p53 in cancer cells X Liu, R Wilcken, AC Joerger, IS Chuckowree, J Amin, J Spencer, ... Nucleic acids research 41 (12), 6034-6044, 2013	243	2013
Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis and adrenal insufficiency S Lovric, S Goncalves, HY Gee, B Oskouian, H Srinivas, WI Choi, S Shril, ... The Journal of clinical investigation 127 (3), 912-928, 2017	193	2017
Kinetic mechanism of p53 oncogenic mutant aggregation and its inhibition R Wilcken, GZ Wang, FM Boeckler, AR Fersht Proceedings of the National Academy of Sciences 109 (34), 13584-13589, 2012	124	2012
Using halogen bonds to address the protein backbone: a systematic evaluation R Wilcken, MO Zimmermann, A Lange, S Zahn, FM Boeckler Journal of computer-aided molecular design 26, 935-945, 2012	101	2012
Structure of the SAS-6 cartwheel hub from Leishmania major M van Breugel, R Wilcken, SH McLaughlin, TJ Rutherford, CM Johnson Elife 3, e01812, 2014	67	2014
Lithocholic acid is an endogenous inhibitor of MDM4 and MDM2 SM Vogel, MR Bauer, AC Joerger, R Wilcken, T Brandt, DB Veprintsev, ... Proceedings of the National Academy of Sciences 109 (42), 16906-16910, 2012	65	2012
Harnessing fluorine–sulfur contacts and multipolar interactions for the design of p53 mutant Y220C rescue drugs MR Bauer, RN Jones, MGJ Baud, R Wilcken, FM Boeckler, AR Fersht, ... ACS chemical biology 11 (8), 2265-2274, 2016	64	2016
Exploiting transient protein states for the design of small-molecule stabilizers of mutant p53 AC Joerger, MR Bauer, R Wilcken, MGJ Baud, H Harbrecht, TE Exner, ... Structure 23 (12), 2246-2255, 2015	58	2015
Synthesis and molecular modeling of novel tetrahydro-β-carboline derivatives with phosphodiesterase 5 inhibitory and anticancer properties HA Mohamed, NMR Girgis, R Wilcken, MR Bauer, HN Tinsley, BD Gary, ... Journal of medicinal chemistry 54 (2), 495-509, 2011	58	2011
Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRAS^G12C A Weiss, E Lorthiois, L Barys, KS Beyer, C Bomio-Confaglia, H Burks, ... Cancer Discovery 12 (6), 1500-1517, 2022	55	2022
High accuracy quantum-chemistry-based calculation and blind prediction of macroscopic pKa values in the context of the SAMPL6 challenge P Pracht, R Wilcken, A Udvarhelyi, S Rodde, S Grimme Journal of Computer-Aided Molecular Design 32, 1139-1149, 2018	55	2018
Addressing methionine in molecular design through directed sulfur–halogen bonds R Wilcken, MO Zimmermann, A Lange, S Zahn, B Kirchner, FM Boeckler Journal of chemical theory and computation 7 (7), 2307-2315, 2011	54	2011
Machine learning estimates of natural product conformational energies M Rupp, MR Bauer, R Wilcken, A Lange, M Reutlinger, FM Boeckler, ... PLoS computational biology 10 (1), e1003400, 2014	42	2014
Halogen-enriched fragment libraries as chemical probes for harnessing halogen bonding in fragment-based lead discovery MO Zimmermann, A Lange, R Wilcken, MB Cieslik, TE Exner, AC Joerger, ... Future medicinal chemistry 6 (6), 617-639, 2014	40	2014
Tracing the evolution of the p53 tetramerization domain AC Joerger, R Wilcken, A Andreeva Structure 22 (9), 1301-1310, 2014	38	2014
JDQ443, a Structurally Novel, Pyrazole-Based, Covalent Inhibitor of KRAS^G12C for the Treatment of Solid Tumors E Lorthiois, M Gerspacher, KS Beyer, A Vaupel, C Leblanc, R Stringer, ... Journal of medicinal chemistry 65 (24), 16173-16203, 2022	33	2022
Benchmarking different QM levels for usage with COSMO-RS J Reinisch, M Diedenhofen, R Wilcken, A Udvarhelyi, A Glöß Journal of Chemical Information and Modeling 59 (11), 4806-4813, 2019	28	2019
Targeting Histidine Side Chains in Molecular Design through Nitrogen–Halogen Bonds A Lange, MO Zimmermann, R Wilcken, S Zahn, FM Boeckler Journal of chemical information and modeling 53 (12), 3178-3189, 2013	27	2013

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