Lynn L. Silver
Lynn L. Silver
President, LL Silver Consulting, LLC
Verified email at
TitleCited byYear
Challenges of antibacterial discovery
LL Silver
Clinical microbiology reviews 24 (1), 71-109, 2011
Platensimycin is a selective FabF inhibitor with potent antibiotic properties
J Wang, SM Soisson, K Young, W Shoop, S Kodali, A Galgoci, R Painter, ...
Nature 441 (7091), 358-361, 2006
Outbreak of Klebsiella pneumoniae producing a new carbapenem-hydrolyzing class A β-lactamase, KPC-3, in a New York medical center
N Woodford, PM Tierno, K Young, L Tysall, MFI Palepou, E Ward, ...
Antimicrobial agents and chemotherapy 48 (12), 4793-4799, 2004
Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis
E Tacconelli, E Carrara, et al.
The Lancet Infectious Diseases, 2017
Antibacterial agents that inhibit lipid A biosynthesis
HR Onishi, BA Pelak, LS Gerckens, LL Silver, FM Kahan, MH Chen, ...
Science 274 (5289), 980-982, 1996
Vancomycin derivatives that inhibit peptidoglycan biosynthesis without binding D-Ala-D-Ala
M Ge, Z Chen, H Russell, J Kohler, LL Silver, R Kerns, S Fukuzawa, ...
Science 284 (5413), 507-511, 1999
Discovery and development of new antibiotics: the problem of antibiotic resistance.
LL Silver, KA Bostian
Antimicrobial agents and chemotherapy 37 (3), 377, 1993
Multi-targeting by monotherapeutic antibacterials
LL Silver
Nature Reviews Drug Discovery 6 (1), 41-55, 2007
Discovery of FabH/FabF inhibitors from natural products
K Young, H Jayasuriya, JG Ondeyka, K Herath, C Zhang, S Kodali, ...
Antimicrobial agents and chemotherapy 50 (2), 519-526, 2006
The envA permeability/cell division gene of Escherichia coli encodes the second enzyme of lipid A biosynthesis
K Young, LL Silver, D Bramhill, P Cameron, SS Eveland, CRH Raetz, ...
Journal of Biological Chemistry 270 (51), 30384-30391, 1995
Bacteriophage T4 gene 41 protein, required for the synthesis of RNA primers, is also a DNA helicase.
M Venkatesan, LL Silver, NG Nossal
Journal of Biological Chemistry 257 (20), 12426-12434, 1982
Determination of selectivity and efficacy of fatty acid synthesis inhibitors
S Kodali, A Galgoci, K Young, R Painter, LL Silver, KB Herath, SB Singh, ...
Journal of Biological Chemistry 280 (2), 1669-1677, 2005
Novel inhibitors of bacterial cell wall synthesis
LL Silver
Current opinion in microbiology 6 (5), 431-438, 2003
Screening of natural products for antimicrobial agents
L Silver, K Bostian
European Journal of Clinical Microbiology & Infectious Diseases 9 (7), 455-461, 1990
In vitro activities of the potent, broad-spectrum carbapenem MK-0826 (L-749,345) against broad-spectrum β-lactamase-and extended-spectrum β-lactamase-producing Klebsiella …
J Kohler, KL Dorso, K Young, GG Hammond, H Rosen, H Kropp, LL Silver
Antimicrobial agents and chemotherapy 43 (5), 1170-1176, 1999
Does the cell wall of bacteria remain a viable source of targets for novel antibiotics?
LL Silver
Biochemical pharmacology 71 (7), 996-1005, 2006
The Role of Hydrophobic Substituents in the Biological Activity of Glycopeptide Antibiotics
R Kerns, SD Dong, S Fukuzawa, J Carbeck, J Kohler, L Silver, D Kahne
JOURNAL-AMERICAN CHEMICAL SOCIETY 122 (50), 12608-12609, 2000
Inhibition of IMP-1 metallo-β-lactamase and sensitization of IMP-1-producing bacteria by thioester derivatives
GG Hammond, JL Huber, ML Greenlee, JB Laub, K Young, LL Silver, ...
FEMS microbiology letters 179 (2), 289-296, 1999
DNA Replication
R McMacken, L Silver, C Georgopoulos
Escherichia coli and Salmonella typhimurium: Cellular and Molecular Biology …, 1987
A Gestalt approach to Gram-negative entry
LL Silver
Bioorganic & medicinal chemistry 24 (24), 6379-6389, 2016
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