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Nicholas G. Paciaroni
Nicholas G. Paciaroni
Medical Science Liaison - The Binding Site, part of Thermo Fisher Scientific
Dirección de correo verificada de thermofisher.com
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A tryptoline ring‐distortion strategy leads to complex and diverse biologically active molecules from the indole alkaloid yohimbine
NG Paciaroni, R Ratnayake, JH Matthews, VM Norwood IV, AC Arnold, ...
Chemistry–A European Journal 23 (18), 4327-4335, 2017
702017
Bromophenazine derivatives with potent inhibition, dispersion and eradication activities against Staphylococcus aureus biofilms
AT Garrison, F Bai, Y Abouelhassan, NG Paciaroni, S Jin, RW Huigens III
Rsc Advances 5 (2), 1120-1124, 2015
512015
Beyond protein binding: recent advances in screening DNA-encoded libraries
T Kodadek, NG Paciaroni, M Balzarini, P Dickson
Chemical Communications 55 (89), 13330-13341, 2019
432019
Solid-phase synthesis of DNA-encoded libraries via an “aldehyde explosion” strategy
NG Paciaroni, JM Ndungu, T Kodadek
Chemical communications 56 (34), 4656-4659, 2020
322020
Re-engineering of yohimbine’s biological activity through ring distortion: identification and structure–activity relationships of a new class of antiplasmodial agents
NG Paciaroni, DL Perry, VM Norwood IV, C Murillo-Solano, J Collins, ...
ACS infectious diseases 6 (2), 159-167, 2020
212020
Synthesis and Screening of a DNA‐Encoded Library of Non‐Peptidic Macrocycles
E Koesema, A Roy, NG Paciaroni, C Coito, M Tokmina‐Roszyk, ...
Angewandte Chemie 134 (18), e202116999, 2022
182022
Yohimbine as a starting point to access diverse natural product-like agents with re-programmed activities against cancer-relevant GPCR targets
NG Paciaroni, VM Norwood IV, R Ratnayake, H Luesch, RW Huigens III
Bioorganic & medicinal chemistry 28 (14), 115546, 2020
162020
VM t. Norwood, AC Arnold, LH Dang, H. Luesch, RW Huigens 3rd
NG Paciaroni, R Ratnayake, JH Matthews
Chem. Eur. J 23, 4327-4335, 2017
62017
Rapid Synthesis of Phenazine-1-Carboxylic Acid Derived SmallMolecules from Diverse Anilines: Privileged Structures for Discovery
NG Paciaroni, NV Borrero, JR Rocca, RW Huigens III
Res. Rev.: J. Med. Org. Chem 2, 67-76, 2015
62015
Microwave-enhanced, stereospecific ring-closure of medium-ring cyanamide ethers to yohimbine
NG Paciaroni, VM Norwood IV, DE Garcia, RW Huigens III
Tetrahedron letters 60 (17), 1182-1185, 2019
22019
First-in-class multifunctional TYMS nonclassical antifolate inhibitor with potent in vivo activity that prolongs survival
MV Guijarro, PC Kellish, PE Dib, NG Paciaroni, A Nawab, J Andring, ...
JCI insight 8 (10), 2023
12023
Back Cover: A Tryptoline Ring‐Distortion Strategy Leads to Complex and Diverse Biologically Active Molecules from the Indole Alkaloid Yohimbine (Chem. Eur. J. 18/2017)
NG Paciaroni, R Ratnayake, JH Matthews, VM Norwood IV, AC Arnold, ...
Chemistry–A European Journal 23 (18), 4463-4463, 2017
12017
First in class multifunctional non classical antifolates inhibits thymidylate synthase and extends survival in pancreatic cancer model
MV Guijarro, PC Kellish, PE Dib, NG Paciaroni, A Nawab, J Andring, ...
Cancer Research 82 (12_Supplement), 4055-4055, 2022
2022
Analogs of yohimbine and uses thereof
RW Huigens III, NG Paciaroni, H Luesch
US Patent 11,242,331, 2022
2022
Ring Distortion of Yohimbine Leads to Diverse Biological Discoveries
NG Paciaroni
University of Florida, 2018
2018
Analogs of yohimbine and uses thereof
RW HUIGENS III, NG PACIARONI
2017
Research & Reviews: Journal of Medicinal & Organic Chemistry
NG Paciaroni, NV Borrero, JR Rocca, RWH III
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Artículos 1–17