| Direct observation of the interconversion of normal and toxic forms of α-synuclein N Cremades, SIA Cohen, E Deas, AY Abramov, AY Chen, A Orte, ... Cell 149 (5), 1048-1059, 2012 | 958 | 2012 |
| The extracellular chaperone clusterin sequesters oligomeric forms of the amyloid-β1−40 peptide P Narayan, A Orte, RW Clarke, B Bolognesi, S Hook, KA Ganzinger, ... Nature structural & molecular biology 19 (1), 79-83, 2012 | 297 | 2012 |
| Direct characterization of amyloidogenic oligomers by single-molecule fluorescence A Orte, NR Birkett, RW Clarke, GL Devlin, CM Dobson, D Klenerman Proceedings of the National Academy of Sciences 105 (38), 14424-14429, 2008 | 213 | 2008 |
| Trapping of proteins under physiological conditions in a nanopipette RW Clarke, SS White, D Zhou, L Ying, D Klenerman Angewandte Chemie 117 (24), 3813-3816, 2005 | 150 | 2005 |
| Single-molecule level analysis of the subunit composition of the T cell receptor on live T cells JR James, SS White, RW Clarke, AM Johansen, PD Dunne, DL Sleep, ... Proceedings of the National Academy of Sciences 104 (45), 17662-17667, 2007 | 94 | 2007 |
| Surface conductivity of biological macromolecules measured by nanopipette dielectrophoresis RW Clarke, JD Piper, L Ying, D Klenerman Physical review letters 98 (19), 198102, 2007 | 88 | 2007 |
| Determination of the fraction and stoichiometry of femtomolar levels of biomolecular complexes in an excess of monomer using single-molecule, two-color coincidence detection A Orte, R Clarke, S Balasubramanian, D Klenerman Analytical chemistry 78 (22), 7707-7715, 2006 | 87 | 2006 |
| A renewable nanosensor based on a glass nanopipette JD Piper, RW Clarke, YE Korchev, L Ying, D Klenerman Journal of the American Chemical Society 128 (51), 16462-16463, 2006 | 66 | 2006 |
| Pipette–surface interaction: current enhancement and intrinsic force RW Clarke, A Zhukov, O Richards, N Johnson, V Ostanin, D Klenerman Journal of the American Chemical Society 135 (1), 322-329, 2013 | 57 | 2013 |
| Hydrodynamic trapping of molecules in lipid bilayers P Jönsson, J McColl, RW Clarke, VP Ostanin, B Jönsson, D Klenerman Proceedings of the National Academy of Sciences 109 (26), 10328-10333, 2012 | 50 | 2012 |
| Analysis of human telomerase activity and function by two color single molecule coincidence fluorescence spectroscopy X Ren, H Li, RW Clarke, DA Alves, L Ying, D Klenerman, ... Journal of the American Chemical Society 128 (15), 4992-5000, 2006 | 50 | 2006 |
| Application of computational mechanics to the analysis of natural data: An example in geomagnetism RW Clarke, MP Freeman, NW Watkins Physical Review E 67 (1), 016203, 2003 | 48 | 2003 |
| Low stress ion conductance microscopy of sub-cellular stiffness RW Clarke, P Novak, A Zhukov, EJ Tyler, M Cano-Jaimez, A Drews, ... Soft Matter 12 (38), 7953-7958, 2016 | 46 | 2016 |
| Optimized threshold selection for single-molecule two-color fluorescence coincidence spectroscopy RW Clarke, A Orte, D Klenerman Analytical chemistry 79 (7), 2771-2777, 2007 | 39 | 2007 |
| Single molecule fluorescence under conditions of fast flow MH Horrocks, H Li, J Shim, RT Ranasinghe, RW Clarke, WTS Huck, ... Analytical chemistry 84 (1), 179-185, 2012 | 38 | 2012 |
| Single-molecule two-colour coincidence detection to probe biomolecular associations A Orte, R Clarke, D Klenerman Biochemical Society Transactions 38 (4), 914-918, 2010 | 32 | 2010 |
| Fluorescence coincidence spectroscopy for single-molecule fluorescence resonance energy-transfer measurements A Orte, RW Clarke, D Klenerman Analytical chemistry 80 (22), 8389-8397, 2008 | 25 | 2008 |
| Realizing the biological and biomedical potential of nanoscale imaging using a pipette probe AI Shevchuk, P Novak, Y Takahashi, R Clarke, M Miragoli, B Babakinejad, ... Nanomedicine 6 (3), 565-575, 2011 | 24 | 2011 |
| Two-color fluorescence analysis of individual virions determines the distribution of the copy number of proteins in herpes simplex virus particles RW Clarke, N Monnier, H Li, D Zhou, H Browne, D Klenerman Biophysical journal 93 (4), 1329-1337, 2007 | 24 | 2007 |
| Forces and structures of the herpes simplex virus (HSV) entry mechanism RW Clarke ACS Infectious Diseases 1 (9), 403-415, 2015 | 17 | 2015 |
