Peter Tonge
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Drug–target residence time: critical information for lead optimization
H Lu, PJ Tonge
Current opinion in chemical biology 14 (4), 467-474, 2010
3682010
The isoniazid-NAD adduct is a slow, tight-binding inhibitor of InhA, the Mycobacterium tuberculosis enoyl reductase: adduct affinity and drug resistance
R Rawat, A Whitty, PJ Tonge
Proceedings of the National Academy of Sciences 100 (24), 13881-13886, 2003
3532003
Drug discovery using chemical systems biology: repositioning the safe medicine Comtan to treat multi-drug and extensively drug resistant tuberculosis
SL Kinnings, N Liu, N Buchmeier, PJ Tonge, L Xie, PE Bourne
PLoS Comput Biol 5 (7), e1000423, 2009
3062009
High affinity InhA inhibitors with activity against drug-resistant strains of Mycobacterium tuberculosis
TJ Sullivan, JJ Truglio, ME Boyne, P Novichenok, X Zhang, CF Stratton, ...
ACS chemical biology 1 (1), 43-53, 2006
2702006
Inhibition of InhA, the enoyl reductase from Mycobacterium tuberculosis, by triclosan and isoniazid
SL Parikh, G Xiao, PJ Tonge
Biochemistry 39 (26), 7645-7650, 2000
2682000
Structural basis and mechanism of enoyl reductase inhibition by triclosan
MJ Stewart, S Parikh, G Xiao, PJ Tonge, C Kisker
Journal of molecular biology 290 (4), 859-865, 1999
2491999
Inhibitors of FabI, an enzyme drug target in the bacterial fatty acid biosynthesis pathway
H Lu, PJ Tonge
Accounts of chemical research 41 (1), 11-20, 2008
2272008
Observation of excited-state proton transfer in green fluorescent protein using ultrafast vibrational spectroscopy
D Stoner-Ma, AA Jaye, P Matousek, M Towrie, SR Meech, PJ Tonge
Journal of the American Chemical Society 127 (9), 2864-2865, 2005
2072005
Probing the ground state structure of the green fluorescent protein chromophore using Raman spectroscopy
AF Bell, X He, RM Wachter, PJ Tonge
Biochemistry 39 (15), 4423-4431, 2000
1962000
A slow, tight binding inhibitor of InhA, the enoyl-acyl carrier protein reductase from Mycobacterium tuberculosis
SR Luckner, N Liu, CW Am Ende, PJ Tonge, C Kisker
Journal of Biological Chemistry 285 (19), 14330-14337, 2010
1802010
Roles of tyrosine 158 and lysine 165 in the catalytic mechanism of InhA, the enoyl-ACP reductase from Mycobacterium tuberculosis
S Parikh, DP Moynihan, G Xiao, PJ Tonge
Biochemistry 38 (41), 13623-13634, 1999
1801999
Novel Trisubstituted Benzimidazoles, Targeting Mtb FtsZ, as a New Class of Antitubercular Agents
K Kumar, D Awasthi, SY Lee, I Zanardi, B Ruzsicska, S Knudson, ...
Journal of medicinal chemistry 54 (1), 374-381, 2011
1512011
Marine natural products from the Turkish sponge Agelas oroides that inhibit the enoyl reductases from Plasmodium falciparum, Mycobacterium tuberculosis and Escherichia coli
D Tasdemir, B Topaloglu, R Perozzo, R Brun, R O’Neill, NM Carballeira, ...
Bioorganic & medicinal chemistry 15 (21), 6834-6845, 2007
1432007
Inhibition of the bacterial enoyl reductase FabI by triclosan: a structure− reactivity analysis of FabI inhibition by triclosan analogues
S Sivaraman, TJ Sullivan, F Johnson, P Novichenok, G Cui, C Simmerling, ...
Journal of medicinal chemistry 47 (3), 509-518, 2004
1392004
A machine learning-based method to improve docking scoring functions and its application to drug repurposing
SL Kinnings, N Liu, PJ Tonge, RM Jackson, L Xie, PE Bourne
Journal of chemical information and modeling 51 (2), 408-419, 2011
1342011
Targeting FtsZ for antituberculosis drug discovery: noncytotoxic taxanes as novel antituberculosis agents
Q Huang, F Kirikae, T Kirikae, A Pepe, A Amin, L Respicio, RA Slayden, ...
Journal of medicinal chemistry 49 (2), 463-466, 2006
1342006
Structure−Activity Studies of the Inhibition of FabI, the Enoyl Reductase from Escherichia coli, by Triclosan:  Kinetic Analysis of Mutant FabIs
S Sivaraman, J Zwahlen, AF Bell, L Hedstrom, PJ Tonge
Biochemistry 42 (15), 4406-4413, 2003
1222003
Slow-Onset Inhibition of the FabI Enoyl Reductase from Francisella tularensis: Residence Time and in Vivo Activity
H Lu, K England, C am Ende, JJ Truglio, S Luckner, BG Reddy, ...
ACS chemical biology 4 (3), 221-231, 2009
1202009
Light-driven decarboxylation of wild-type green fluorescent protein
AF Bell, D Stoner-Ma, RM Wachter, PJ Tonge
Journal of the American Chemical Society 125 (23), 6919-6926, 2003
1142003
Crystal structure of Mycobacterium tuberculosis MenB, a key enzyme in vitamin K2 biosynthesis
JJ Truglio, K Theis, Y Feng, R Gajda, C Machutta, PJ Tonge, C Kisker
Journal of Biological Chemistry 278 (43), 42352-42360, 2003
1122003
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