| Structure of the DDB1–CRBN E3 ubiquitin ligase in complex with thalidomide ES Fischer, K Böhm, JR Lydeard, H Yang, MB Stadler, S Cavadini, ... Nature 512 (7512), 49-53, 2014 | 944 | 2014 |
| Identification and mechanistic characterization of low-molecular-weight inhibitors for HuR NC Meisner, M Hintersteiner, K Mueller, R Bauer, JM Seifert, HU Naegeli, ... Nature chemical biology 3 (8), 508-515, 2007 | 228 | 2007 |
| Recognition and catabolism of synthetic heterotrimeric collagen peptides by matrix metalloproteinases J Ottl, D Gabriel, G Murphy, V Knäuper, Y Tominaga, H Nagase, M Kröger, ... Chemistry & biology 7 (2), 119-132, 2000 | 144 | 2000 |
| Design and synthesis of heterotrimeric collagen peptides with a built‐in cystine‐knot Models for collagen catabolism by matrix‐metalloproteases J Ottl, R Battistuta, M Pieper, H Tschesche, W Bode, K Kühn, L Moroder FEBS letters 398 (1), 31-36, 1996 | 125 | 1996 |
| Disulfide-bridged heterotrimeric collagen peptides containing the collagenase cleavage site of collagen type I. Synthesis and conformational properties J Ottl, L Moroder Journal of the American Chemical Society 121 (4), 653-661, 1999 | 118 | 1999 |
| Crystal structure of human estrogen-related receptor α in complex with a synthetic inverse agonist reveals its novel molecular mechanism J Kallen, R Lattmann, R Beerli, A Blechschmidt, MJJ Blommers, M Geiser, ... Journal of Biological Chemistry 282 (32), 23231-23239, 2007 | 101 | 2007 |
| Preparation and photoactivation of caged fluorophores and caged proteins using a new class of heterobifunctional, photocleavable cross-linking reagents J Ottl, D Gabriel, G Marriott Bioconjugate chemistry 9 (2), 143-151, 1998 | 87 | 1998 |
| Encoded library technologies as integrated lead finding platforms for drug discovery J Ottl, L Leder, JV Schaefer, CE Dumelin Molecules 24 (8), 1629, 2019 | 82 | 2019 |
| Characterization of phosphopeptide motifs specific for the Src homology 2 domains of signal transducer and activator of transcription 1 (STAT1) and STAT3 M Wiederkehr-Adam, P Ernst, K Müller, E Bieck, FO Gombert, J Ottl, ... Journal of Biological Chemistry 278 (18), 16117-16128, 2003 | 77 | 2003 |
| Synthesis and characterization of fluorescent ubiquitin derivatives as highly sensitive substrates for the deubiquitinating enzymes UCH-L3 and USP-2 A Tirat, A Schilb, V Riou, L Leder, B Gerhartz, J Zimmermann, ... Analytical biochemistry 343 (2), 244-255, 2005 | 72 | 2005 |
| Structure of lipoprotein lipase in complex with GPIHBP1 R Arora, AV Nimonkar, D Baird, C Wang, CH Chiu, PA Horton, ... Proceedings of the National Academy of Sciences 116 (21), 10360-10365, 2019 | 62 | 2019 |
| Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C A Weiss, E Lorthiois, L Barys, KS Beyer, C Bomio-Confaglia, H Burks, ... Cancer Discovery 12 (6), 1500-1517, 2022 | 56 | 2022 |
| Discovery and molecular basis of a diverse set of polycomb repressive complex 2 inhibitors recognition by EED L Li, H Zhang, M Zhang, M Zhao, L Feng, X Luo, Z Gao, Y Huang, ... PLoS One 12 (1), e0169855, 2017 | 56 | 2017 |
| Heterotrimeric collagen peptides as fluorogenic collagenase substrates: synthesis, conformational properties, and enzymatic digestion JCD Müller, J Ottl, L Moroder Biochemistry 39 (17), 5111-5116, 2000 | 56 | 2000 |
| Affinity-based screening techniques: their impact and benefit to increase the number of high quality leads C Bergsdorf, J Ottl Expert opinion on drug discovery 5 (11), 1095-1107, 2010 | 53 | 2010 |
| Readout technologies for highly miniaturized kinase assays applicable to high-throughput screening in a 1536-well format M Klumpp, A Boettcher, D Becker, G Meder, J Blank, L Leder, M Forstner, ... Journal of biomolecular screening 11 (6), 617-633, 2006 | 51 | 2006 |
| [9] Synthesis and applications of heterobifunctional photocleavable cross-linking reagents G Marriott, J Ottl Methods in enzymology 291, 155-175, 1998 | 48 | 1998 |
| Heterotrimeric collagen peptides containing functional epitopes. Synthesis of single‐stranded collagen type I peptides related to the collagenase cleavage site J Ottl, H Jürgen Musiol, L Moroder Journal of peptide science: an official publication of the European Peptide …, 1999 | 44 | 1999 |
| Large scale meta-analysis of fragment-based screening campaigns: privileged fragments and complementary technologies PS Kutchukian, AM Wassermann, MK Lindvall, SK Wright, J Ottl, J Jacob, ... Journal of biomolecular screening 20 (5), 588-596, 2015 | 36 | 2015 |
| JDQ443, a Structurally Novel, Pyrazole-Based, Covalent Inhibitor of KRASG12C for the Treatment of Solid Tumors E Lorthiois, M Gerspacher, KS Beyer, A Vaupel, C Leblanc, R Stringer, ... Journal of medicinal chemistry 65 (24), 16173-16203, 2022 | 33 | 2022 |
