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Mirjam Brackhan
Mirjam Brackhan
Associate researcher at Instituto de Investigación Sanitaria del Hospital Clínico San Carlos
Dirección de correo verificada de salud.madrid.org
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Serial quantitative TSPO-targeted PET reveals peak microglial activation up to 2 weeks after an epileptogenic brain insult
M Brackhan, P Bascuñana, JM Postema, TL Ross, FM Bengel, ...
Journal of Nuclear Medicine 57 (8), 1302-1308, 2016
602016
Fingolimod as a treatment in neurologic disorders beyond multiple sclerosis
P Bascuñana, L Möhle, M Brackhan, J Pahnke
Drugs in R&D 20, 197-207, 2020
352020
French maritime pine bark treatment decelerates plaque development and improves spatial memory in Alzheimer's disease mice
K Paarmann, SR Prakash, M Krohn, L Möhle, M Brackhan, T Brüning, ...
Phytomedicine 57, 39-48, 2019
252019
Imaging P-Glycoprotein Induction at the Blood–Brain Barrier of a β-Amyloidosis Mouse Model with 11C-Metoclopramide PET
V Zoufal, S Mairinger, M Brackhan, M Krohn, T Filip, M Sauberer, J Stanek, ...
Journal of Nuclear Medicine 61 (7), 1050-1057, 2020
242020
[18F]GE180 positron emission tomographic imaging indicates a potential double‐hit insult in the intrahippocampal kainate mouse model of temporal lobe epilepsy
M Brackhan, P Bascuñana, TL Ross, FM Bengel, JP Bankstahl, ...
Epilepsia 59 (3), 617-626, 2018
242018
Strategies to gain novel Alzheimer’s disease diagnostics and therapeutics using modulators of ABCA transporters
J Pahnke, P Bascuñana, M Brackhan, K Stefan, V Namasivayam, ...
Free neuropathology 2, 2021
172021
Development of deep learning models for microglia analyses in brain tissue using DeePathology™ STUDIO
L Möhle, P Bascunana, M Brackhan, J Pahnke
Journal of neuroscience methods 364, 109371, 2021
152021
Divergent metabolic substrate utilization in brain during epileptogenesis precedes chronic hypometabolism
P Bascuñana, M Brackhan, I Leiter, H Keller, I Jahreis, TL Ross, ...
Journal of Cerebral Blood Flow & Metabolism 40 (1), 204-213, 2020
152020
Dimethyl fumarate does not mitigate cognitive decline and β-amyloidosis in female APPPS1 mice
L Möhle, M Brackhan, P Bascunana, J Pahnke
Brain Research 1768, 147579, 2021
142021
Machine learning-supported analyses improve quantitative histological assessments of amyloid-β deposits and activated microglia
P Bascuñana, M Brackhan, J Pahnke
Journal of Alzheimer's Disease 79 (2), 597-605, 2021
132021
TSPO PET identifies different anti-inflammatory minocycline treatment response in two rodent models of epileptogenesis
BJ Wolf, M Brackhan, P Bascuñana, I Leiter, BLN Langer, TL Ross, ...
Neurotherapeutics 17 (3), 1228-1238, 2020
132020
99mTc-HMPAO SPECT imaging reveals brain hypoperfusion during status epilepticus
P Bascuñana, BJ Wolf, I Jahreis, M Brackhan, L García-García, TL Ross, ...
Metabolic brain disease 36, 2597-2602, 2021
72021
Generation and characterization of an Abcc1 humanized mouse model (hABCC1flx/flx) with knockout capability
M Krohn, V Zoufal, S Mairinger, T Wanek, K Paarmann, T Brüning, I Eiriz, ...
Molecular pharmacology 96 (2), 138-147, 2019
72019
Isotope‐labeled amyloid‐β does not transmit to the brain in a prion‐like manner after peripheral administration
M Brackhan, G Calza, K Lundgren, P Bascunana, T Brüning, R Soliymani, ...
EMBO reports 23 (7), e54405, 2022
62022
Brain distribution of dual ABCB1/ABCG2 substrates is unaltered in a beta-amyloidosis mouse model
T Wanek, V Zoufal, M Brackhan, M Krohn, S Mairinger, T Filip, M Sauberer, ...
International Journal of Molecular Sciences 21 (21), 8245, 2020
62020
ABC transporter C1 prevents dimethyl fumarate from targeting Alzheimer’s disease
L Möhle, K Stefan, P Bascuñana, M Brackhan, T Brüning, I Eiriz, ...
Biology 12 (7), 932, 2023
52023
Time-and sex-dependent effects of fingolimod treatment in a mouse model of alzheimer’s disease
P Bascuñana, M Brackhan, L Möhle, J Wu, T Brüning, I Eiriz, B Jansone, ...
Biomolecules 13 (2), 331, 2023
52023
Aging, NRF2, and TAU: A Perfect Match for Neurodegeneration?
M Brackhan, M Arribas-Blazquez, I Lastres-Becker
Antioxidants 12 (8), 1564, 2023
42023
Detection and Prediction of Mild Cognitive Impairment in Alzheimer’s Disease Mice
SP Rai, P Bascuñana, M Brackhan, M Krohn, L Möhle, K Paarmann, ...
Journal of Alzheimer's Disease 77 (3), 1209-1221, 2020
42020
A New Tool for the Analysis of the Effect of Intracerebrally Injected Anti-Amyloid-β Compounds
J Upīte, T Brüning, L Möhle, M Brackhan, P Bascuñana, B Jansone, ...
Journal of Alzheimer's Disease 84 (4), 1677-1690, 2021
32021
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