| 4-Hydroxynonenal inhibits SIRT3 via thiol-specific modification KS Fritz, JJ Galligan, RL Smathers, JR Roede, CT Shearn, P Reigan, ... Chemical research in toxicology 24 (5), 651-662, 2011 | 135 | 2011 |
| Oxidative stress and the ER stress response in a murine model for early-stage alcoholic liver disease JJ Galligan, RL Smathers, CT Shearn, KS Fritz, DS Backos, H Jiang, ... Journal of toxicology 2012, 2012 | 113 | 2012 |
| Modification of Akt2 by 4-hydroxynonenal inhibits insulin-dependent Akt signaling in HepG2 cells CT Shearn, KS Fritz, P Reigan, DR Petersen Biochemistry 50 (19), 3984-3996, 2011 | 80 | 2011 |
| Increased carbonylation of the lipid phosphatase PTEN contributes to Akt2 activation in a murine model of early alcohol-induced steatosis CT Shearn, RL Smathers, DS Backos, P Reigan, DJ Orlicky, DR Petersen Free Radical Biology and Medicine 65, 680-692, 2013 | 77 | 2013 |
| Characterization of 4-HNE modified L-FABP reveals alterations in structural and functional dynamics RL Smathers, KS Fritz, JJ Galligan, CT Shearn, P Reigan, MJ Marks, ... PloS one 7 (6), e38459, 2012 | 71 | 2012 |
| Hepatocyte hyperproliferation upon liver-specific co-disruption of thioredoxin-1, thioredoxin reductase-1, and glutathione reductase JR Prigge, L Coppo, SS Martin, F Ogata, CG Miller, MD Bruschwein, ... Cell reports 19 (13), 2771-2781, 2017 | 66 | 2017 |
| Nocturnal hypoxia-induced oxidative stress promotes progression of pediatric non-alcoholic fatty liver disease SS Sundaram, A Halbower, Z Pan, K Robbins, KE Capocelli, J Klawitter, ... Journal of hepatology 65 (3), 560-569, 2016 | 66 | 2016 |
| Chronic ethanol consumption induces mitochondrial protein acetylation and oxidative stress in the kidney PS Harris, SR Roy, C Coughlan, DJ Orlicky, Y Liang, CT Shearn, ... Redox biology 6, 33-40, 2015 | 66 | 2015 |
| TrxR1, Gsr, and oxidative stress determine hepatocellular carcinoma malignancy MR McLoughlin, DJ Orlicky, JR Prigge, P Krishna, EA Talago, IR Cavigli, ... Proceedings of the National Academy of Sciences 116 (23), 11408-11417, 2019 | 61 | 2019 |
| Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) signaling regulates mitochondrial biogenesis and respiration via estrogen-related receptor α (ERRα) Y Li, L He, N Zeng, D Sahu, E Cadenas, C Shearn, W Li, BL Stiles Journal of Biological Chemistry 288 (35), 25007-25024, 2013 | 60 | 2013 |
| Identification of 5′ AMP-activated kinase as a target of reactive aldehydes during chronic ingestion of high concentrations of ethanol CT Shearn, DS Backos, DJ Orlicky, RL Smathers-McCullough, ... Journal of Biological Chemistry 289 (22), 15449-15462, 2014 | 55 | 2014 |
| Increased dietary fat contributes to dysregulation of the LKB1/AMPK pathway and increased damage in a mouse model of early-stage ethanol-mediated steatosis CT Shearn, RL Smathers, H Jiang, DJ Orlicky, KN Maclean, DR Petersen The Journal of nutritional biochemistry 24 (8), 1436-1445, 2013 | 55 | 2013 |
| Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibition by 4-hydroxynonenal leads to increased Akt activation in hepatocytes CT Shearn, RL Smathers, BJ Stewart, KS Fritz, JJ Galligan, N Hail, ... Molecular pharmacology 79 (6), 941-952, 2011 | 53 | 2011 |
| Susceptibility of L-FABP−/− mice to oxidative stress in early-stage alcoholic liver [S] RL Smathers, JJ Galligan, CT Shearn, KS Fritz, K Mercer, M Ronis, ... Journal of lipid research 54 (5), 1335-1345, 2013 | 52 | 2013 |
| Oxidative stress-mediated aldehyde adduction of GRP78 in a mouse model of alcoholic liver disease: functional independence of ATPase activity and chaperone function JJ Galligan, KS Fritz, DS Backos, CT Shearn, RL Smathers, H Jiang, ... Free Radical Biology and Medicine 73, 411-420, 2014 | 46 | 2014 |
| Dihydroorotate dehydrogenase is required for N-(4-hydroxyphenyl) retinamide-induced reactive oxygen species production and apoptosis N Hail Jr, P Chen, JJ Kepa, LR Bushman, C Shearn Free Radical Biology and Medicine 49 (1), 109-116, 2010 | 46 | 2010 |
| Deletion of GSTA4-4 results in increased mitochondrial post-translational modification of proteins by reactive aldehydes following chronic ethanol consumption in mice CT Shearn, KS Fritz, AH Shearn, LM Saba, KE Mercer, B Engi, JJ Galligan, ... Redox biology 7, 68-77, 2016 | 42 | 2016 |
| Inhibition of hydrogen peroxide signaling by 4-hydroxynonenal due to differential regulation of Akt1 and Akt2 contributes to decreases in cell survival and proliferation in … CT Shearn, P Reigan, DR Petersen Free Radical Biology and Medicine 53 (1), 1-11, 2012 | 41 | 2012 |
| Understanding the tumor suppressor PTEN in chronic alcoholism and hepatocellular carcinoma CT Shearn, DR Petersen Biological Basis of Alcohol-Induced Cancer, 173-184, 2015 | 33 | 2015 |
| Short term feeding of a high fat diet exerts an additive effect on hepatocellular damage and steatosis in liver-specific PTEN knockout mice CT Shearn, KE Mercer, DJ Orlicky, L Hennings, RL Smathers-McCullough, ... PLoS One 9 (5), e96553, 2014 | 32 | 2014 |
