Miguel Mompeán
Miguel Mompeán
Instituto de Química Física "Blas Cabrera", IQF-CSIC
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The structure of the necrosome RIPK1-RIPK3 core, a human hetero-amyloid signaling complex
M Mompeán, W Li, J Li, S Laage, AB Siemer, G Bozkurt, H Wu, ...
Cell 173 (5), 1244-1253. e10, 2018
The TDP‐43 N‐terminal domain structure at high resolution
M Mompeán, V Romano, D Pantoja‐Uceda, C Stuani, FE Baralle, ...
The FEBS journal 283 (7), 1242-1260, 2016
Pushing nuclear magnetic resonance sensitivity limits with microfluidics and photo-chemically induced dynamic nuclear polarization
M Mompeán, RM Sánchez-Donoso, A De La Hoz, V Saggiomo, ...
Nature communications 9 (1), 108, 2018
Structural characterization of the minimal segment of TDP-43 competent for aggregation
M Mompeán, E Buratti, C Guarnaccia, RMM Brito, A Chakrabartty, ...
Archives of biochemistry and biophysics 545, 53-62, 2014
Point mutations in the N-terminal domain of transactive response DNA-binding protein 43 kDa (TDP-43) compromise its stability, dimerization, and functions
M Mompeán, V Romano, D Pantoja-Uceda, C Stuani, FE Baralle, E Buratti, ...
Journal of Biological Chemistry 292 (28), 11992-12006, 2017
Structural evidence of amyloid fibril formation in the putative aggregation domain of TDP-43
M Mompeán, R Hervás, Y Xu, TH Tran, C Guarnaccia, E Buratti, F Baralle, ...
The journal of physical chemistry letters 6 (13), 2608-2615, 2015
An amyloid-like pathological conformation of TDP-43 is stabilized by hypercooperative hydrogen bonds
M Mompeán, M Baralle, E Buratti, DV Laurents
Frontiers in molecular neuroscience 9, 125, 2016
Large-scale recombinant production of the SARS-CoV-2 proteome for high-throughput and structural biology applications
N Altincekic, SM Korn, NS Qureshi, M Dujardin, M Ninot-Pedrosa, R Abele, ...
Frontiers in molecular biosciences 8, 653148, 2021
Electrostatic repulsion governs TDP-43 C-terminal domain aggregation
M Mompeán, A Chakrabartty, E Buratti, DV Laurents
PLoS biology 14 (4), e1002447, 2016
The singular NMR fingerprint of a polyproline II helical bundle
MÁ Treviño, D Pantoja-Uceda, M Menéndez, MV Gomez, M Mompeán, ...
Journal of the American Chemical Society 140 (49), 16988-17000, 2018
SUMOylation regulates TDP-43 splicing activity and nucleocytoplasmic distribution
AM Maraschi, V Gumina, J Dragotto, C Colombrita, M Mompeán, E Buratti, ...
Molecular Neurobiology 58 (11), 5682-5702, 2021
Phe-Gly motifs drive fibrillization of TDP-43’s prion-like domain condensates
D Pantoja-Uceda, C Stuani, DV Laurents, AE McDermott, E Buratti, ...
PLoS biology 19 (4), e3001198, 2021
Dysregulation of TDP‐43 intracellular localization and early onset ALS are associated with a TARDBP S375G variant
K Newell, F Paron, M Mompean, J Murrell, E Salis, C Stuani, G Pattee, ...
Brain Pathology 29 (3), 397-413, 2019
Combining Classical MD and QM Calculations to Elucidate Complex System Nucleation: A Twisted, Three-Stranded, Parallel β-Sheet Seeds Amyloid Fibril Conception
M Mompeán, C González, E Lomba, DV Laurents
The Journal of Physical Chemistry B 118 (26), 7312-7316, 2014
Do polyproline II helix associations modulate biomolecular condensates?
M Mompeán, J Oroz, DV Laurents
FEBS Open bio 11 (9), 2390-2399, 2021
Complex system assembly underlies a two-tiered model of highly delocalized electrons
M Mompean, A Nogales, TA Ezquerra, DV Laurents
The journal of physical chemistry letters 7 (10), 1859-1864, 2016
Molecular mechanism of the inhibition of TDP-43 amyloidogenesis by QBP1
M Mompean, DR de Mingo, R Hervas, M del Carmen Fernandez-Ramirez, ...
Archives of biochemistry and biophysics 675, 108113, 2019
Comprehensive fragment screening of the SARS‐CoV‐2 proteome explores novel chemical space for drug development
H Berg, MA Wirtz Martin, N Altincekic, I Alshamleh, J Kaur Bains, ...
Angewandte Chemie International Edition 61 (46), e202205858, 2022
DMSO affects Aβ 1–40's conformation and interactions with aggregation inhibitors as revealed by NMR
DV Laurents, D Pantoja-Uceda, LC López, JA Carrodeguas, M Mompeán, ...
RSC advances 5 (85), 69761-69764, 2015
Intrinsically disordered domains, amyloids and protein liquid phases: evolving concepts and open questions
M Mompean, D V Laurents
Protein and Peptide Letters 24 (4), 281-293, 2017
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