Eefjan Breukink
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Use of the cell wall precursor lipid II by a pore-forming peptide antibiotic
E Breukink, I Wiedemann, C Van Kraaij, OP Kuipers, HG Sahl, B De Kruijff
Science 286 (5448), 2361-2364, 1999
Specific binding of nisin to the peptidoglycan precursor lipid II combines pore formation and inhibition of cell wall biosynthesis for potent antibiotic activity
I Wiedemann, E Breukink, C van Kraaij, OP Kuipers, G Bierbaum, ...
Journal of Biological Chemistry 276 (3), 1772-1779, 2001
Lipid II as a target for antibiotics
E Breukink, B de Kruijff
Nature reviews Drug discovery 5 (4), 321-323, 2006
The nisin–lipid II complex reveals a pyrophosphate cage that provides a blueprint for novel antibiotics
STD Hsu, E Breukink, E Tischenko, MAG Lutters, B De Kruijff, R Kaptein, ...
Nature structural & molecular biology 11 (10), 963-967, 2004
An alternative bactericidal mechanism of action for lantibiotic peptides that target lipid II
HE Hasper, NE Kramer, JL Smith, JD Hillman, C Zachariah, OP Kuipers, ...
Science 313 (5793), 1636-1637, 2006
The lantibiotic nisin, a special case or not?
E Breukink, B de Kruijff
Biochimica et Biophysica Acta (BBA)-Biomembranes 1462 (1-2), 223-234, 1999
Identification of FtsW as a transporter of lipid‐linked cell wall precursors across the membrane
T Mohammadi, V Van Dam, R Sijbrandi, T Vernet, A Zapun, A Bouhss, ...
The EMBO journal 30 (8), 1425-1432, 2011
Lipid II is an intrinsic component of the pore induced by nisin in bacterial membranes
E Breukink, HE van Heusden, PJ Vollmerhaus, E Swiezewska, L Brunner, ...
Journal of Biological Chemistry 278 (22), 19898-19903, 2003
Regulation of peptidoglycan synthesis by outer-membrane proteins
A Typas, M Banzhaf, BB van Saparoea, J Verheul, J Biboy, RJ Nichols, ...
Cell 143 (7), 1097-1109, 2010
Assembly and stability of nisin− lipid II pores
HE Hasper, B de Kruijff, E Breukink
Biochemistry 43 (36), 11567-11575, 2004
The C-terminal region of nisin is responsible for the initial interaction of nisin with the target membrane
E Breukink, C van Kraaij, RA Demel, RJ Siezen, OP Kuipers, B de Kruijff
Biochemistry 36 (23), 6968-6976, 1997
SecA insertion into phospholipids is stimulated by negatively charged lipids and inhibited by ATP: a monolayer study
E Breukink, RA Demel, G De Korte-Kool, B De Kruijff
Biochemistry 31 (4), 1119-1124, 1992
Natamycin blocks fungal growth by binding specifically to ergosterol without permeabilizing the membrane
YM Te Welscher, H Hendrik, MM Balagué, CM Souza, H Riezman, ...
Journal of Biological Chemistry 283 (10), 6393-6401, 2008
The C terminus of SecA is involved in both lipid binding and SecB binding
E Breukink, N Nouwen, A van Raalte, S Mizushima, J Tommassen, ...
Journal of Biological Chemistry 270 (14), 7902-7907, 1995
Functional interaction of human neutrophil peptide-1 with the cell wall precursor lipid II
E de Leeuw, C Li, P Zeng, C Li, M Diepeveen-de Buin, WY Lu, E Breukink, ...
FEBS letters 584 (8), 1543-1548, 2010
Lipid II induces a transmembrane orientation of the pore-forming peptide lantibiotic nisin
HE van Heusden, B de Kruijff, E Breukink
Biochemistry 41 (40), 12171-12178, 2002
In vitro murein (peptidoglycan) synthesis by dimers of the bifunctional transglycosylase-transpeptidase PBP1B from Escherichia coli
U Bertsche, E Breukink, T Kast, W Vollmer
Journal of Biological Chemistry 280 (45), 38096-38101, 2005
The essential cell division protein FtsN interacts with the murein (peptidoglycan) synthase PBP1B in Escherichia coli
P Müller, C Ewers, U Bertsche, M Anstett, T Kallis, E Breukink, C Fraipont, ...
Journal of Biological Chemistry 282 (50), 36394-36402, 2007
The orientation of nisin in membranes
E Breukink, C van Kraaij, A van Dalen, RA Demel, RJ Siezen, B de Kruijff, ...
Biochemistry 37 (22), 8153-8162, 1998
NMR study of mersacidin and lipid II interaction in dodecylphosphocholine micelles: Conformational changes are a key to antimicrobial activity
STD Hsu, E Breukink, G Bierbaum, HG Sahl, B De Kruijff, R Kaptein, ...
Journal of Biological Chemistry 278 (15), 13110-13117, 2003
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