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Joseph Lorent
Joseph Lorent
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Plasma membranes are asymmetric in lipid unsaturation, packing and protein shape
JH Lorent, KR Levental, L Ganesan, G Rivera-Longsworth, E Sezgin, ...
Nature chemical biology 16 (6), 644-652, 2020
4492020
Structural determinants and functional consequences of protein affinity for membrane rafts
JH Lorent, B Diaz-Rohrer, X Lin, K Spring, AA Gorfe, KR Levental, ...
Nature communications 8 (1), 1219, 2017
2582017
The amphiphilic nature of saponins and their effects on artificial and biological membranes and potential consequences for red blood and cancer cells
JH Lorent, J Quetin-Leclercq, MP Mingeot-Leclercq
Organic & biomolecular chemistry 12 (44), 8803-8822, 2014
2492014
Polyunsaturated lipids regulate membrane domain stability by tuning membrane order
KR Levental, JH Lorent, X Lin, AD Skinkle, MA Surma, EA Stockenbojer, ...
Biophysical journal 110 (8), 1800-1810, 2016
1882016
Structural determinants of protein partitioning into ordered membrane domains and lipid rafts
JH Lorent, I Levental
Chemistry and physics of lipids 192, 23-32, 2015
1622015
Effects of surfactin on membrane models displaying lipid phase separation
M Deleu, J Lorent, L Lins, R Brasseur, N Braun, K El Kirat, T Nylander, ...
Biochimica et Biophysica Acta (BBA)-Biomembranes 1828 (2), 801-815, 2013
1312013
ω-3 polyunsaturated fatty acids direct differentiation of the membrane phenotype in mesenchymal stem cells to potentiate osteogenesis
KR Levental, MA Surma, AD Skinkle, JH Lorent, Y Zhou, C Klose, ...
Science advances 3 (11), eaao1193, 2017
1132017
Induction of highly curved structures in relation to membrane permeabilization and budding by the triterpenoid saponins, α-and δ-Hederin
J Lorent, CS Le Duff, J Quetin-Leclercq, MP Mingeot-Leclercq
Journal of Biological Chemistry 288 (20), 14000-14017, 2013
842013
Mode of action of teixobactins in cellular membranes
R Shukla, J Medeiros-Silva, A Parmar, BJA Vermeulen, S Das, AL Paioni, ...
Nature communications 11 (1), 2848, 2020
802020
Teixobactin kills bacteria by a two-pronged attack on the cell envelope
R Shukla, F Lavore, S Maity, MGN Derks, CR Jones, BJA Vermeulen, ...
Nature 608 (7922), 390-396, 2022
692022
Domain stability in biomimetic membranes driven by lipid polyunsaturation
X Lin, JH Lorent, AD Skinkle, KR Levental, MN Waxham, AA Gorfe, ...
The Journal of Physical Chemistry B 120 (46), 11930-11941, 2016
572016
Domain formation and permeabilization induced by the saponin α-hederin and its aglycone hederagenin in a cholesterol-containing bilayer
J Lorent, L Lins, O Domenech, J Quetin-Leclercq, R Brasseur, ...
Langmuir 30 (16), 4556-4569, 2014
562014
α-Hederin induces apoptosis, membrane permeabilization and morphologic changes in two cancer cell lines through a cholesterol-dependent mechanism
JH Lorent, C Léonard, M Abouzi, F Akabi, J Quetin-Leclercq, ...
Planta Medica 82 (18), 1532-1539, 2016
232016
Myelin-associated MAL and PLP are unusual among multipass transmembrane proteins in preferring ordered membrane domains
I Castello-Serrano, JH Lorent, R Ippolito, KR Levental, I Levental
The Journal of Physical Chemistry B 124 (28), 5930-5939, 2020
202020
Structural modifications controlling membrane raft partitioning and curvature in human and viral proteins
D Yurtsever, JH Lorent
The Journal of Physical Chemistry B 124 (35), 7574-7585, 2020
142020
Shortening of membrane lipid acyl chains compensates for phosphatidylcholine deficiency in choline‐auxotroph yeast
X Bao, MC Koorengevel, MJA Groot Koerkamp, A Homavar, A Weijn, ...
The EMBO journal 40 (20), e107966, 2021
132021
Lipid membranes as key targets for the pharmacological actions of ginsenosides
SL Verstraeten, JH Lorent, MP Mingeot-Leclercq
Frontiers in pharmacology 11, 576887, 2020
132020
The molecular and structural asymmetry of the plasma membrane
JH Lorent, L Ganesan, G Rivera-Longsworth, E Sezgin, KR Levental, ...
BioRxiv, 698837, 2019
122019
The mammalian plasma membrane is defined by transmembrane asymmetries in lipid unsaturation, leaflet packing, and protein shape
J Lorent, K Levental, L Ganesan, G Rivera-Longsworth, E Sezgin, ...
bioRxiv, 2019
82019
Cell Membranes Sustain Phospholipid Imbalance Via Cholesterol Asymmetry
M Doktorova, JL Symons, X Zhang, HY Wang, J Schlegel, JH Lorent, ...
bioRxiv, 2023.07. 30.551157, 2023
72023
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