| Epidermal Growth Factor Receptor Extracellular Domain Mutations in Glioblastoma Present Opportunities for Clinical Imaging and Therapeutic Development ZA Binder, AH Thorne, S Bakas, EP Wileyto, M Bilello, H Akbari, ... Cancer cell 34 (1), 163-177. e7, 2018 | 174 | 2018 |
| Inhibition of nuclear PTEN tyrosine phosphorylation enhances glioma radiation sensitivity through attenuated DNA repair J Ma, JA Benitez, J Li, S Miki, CP de Albuquerque, T Galatro, L Orellana, ... Cancer cell 35 (3), 504-518. e7, 2019 | 144 | 2019 |
| Inhibition of nuclear PTEN tyrosine phosphorylation enhances glioma radiation sensitivity through attenuated DNA repair J Ma, JA Benitez, J Li, S Miki, CP de Albuquerque, T Galatro, L Orellana, ... Cancer cell 35 (3), 504-518. e7, 2019 | 144 | 2019 |
| Large-scale conformational changes and protein function: breaking the in silico barrier L Orellana Frontiers in molecular biosciences 6, 117, 2019 | 113 | 2019 |
| Correlated motions are a fundamental property of β-sheets RB Fenwick, L Orellana, S Esteban-Martín, M Orozco, X Salvatella Nature communications 5 (1), 4070, 2014 | 105 | 2014 |
| FlexServ: an integrated tool for the analysis of protein flexibility J Camps, O Carrillo, A Emperador, L Orellana, A Hospital, M Rueda, ... Bioinformatics 25 (13), 1709-1710, 2009 | 105 | 2009 |
| The molecular basis for sugar import in malaria parasites DD Abdul Aziz Qureshi, Albert Suades, Rei Matsuoka, Joseph Brock, Sarah E ... Nature, 2020 | 82 | 2020 |
| Approaching elastic network models to molecular dynamics flexibility L Orellana, M Rueda, C Ferrer-Costa, JR Lopez-Blanco, P Chacón, ... Journal of Chemical Theory and Computation, 2010 | 80 | 2010 |
| Prediction and validation of protein intermediate states from structurally rich ensembles and coarse-grained simulations L Orellana, O Yoluk, O Carrillo, M Orozco, E Lindahl Nature communications 7 (1), 12575, 2016 | 76 | 2016 |
| Structure and elevator mechanism of the mammalian sodium/proton exchanger NHE9 I Winkelmann, R Matsuoka, PF Meier, D Shutin, C Zhang, L Orellana, ... The EMBO journal 39 (24), 4541-4559, 2020 | 61 | 2020 |
| Oncogenic mutations at the EGFR ectodomain structurally converge to remove a steric hindrance on a kinase-coupled cryptic epitope L Orellana, AH Thorne, R Lema, J Gustavsson, AD Parisian, A Hospital, ... Proceedings of the National Academy of Sciences 116 (20), 10009-10018, 2019 | 53 | 2019 |
| Coarse-grained Representation of Protein Flexibility. Foundations, Successes, and Shortcomings. M OROZCO, L ORELLANA, AN Naganathan, A Emperador, O Carrillo, ... Computational Chemistry Methods in Structural Biology 85, 183, 2011 | 39 | 2011 |
| Structure, mechanism and lipid-mediated remodeling of the mammalian Na+/H+ exchanger NHA2 R Matsuoka, R Fudim, S Jung, C Zhang, A Bazzone, Y Chatzikyriakidou, ... Nature Structural & Molecular Biology 29 (2), 108-120, 2022 | 37 | 2022 |
| Finding Conformational Transition Pathways from Discrete Molecular Dynamics Simulations P Sfriso, A Emperador, L Orellana, A Hospital, JL Gelpí, M Orozco Journal of Chemical Theory and Computation, 0 | 37 | |
| Crystal structures of human MGST2 reveal synchronized conformational changes regulating catalysis. M Thulasingam, L Orellana, E Nji, S Ahmad, A Rinaldo-Matthis, ... Nature Communications 12 (1728), 2021 | 19 | 2021 |
| eBDIMS server: protein transition pathways with ensemble analysis in 2D-motion spaces L Orellana, J Gustavsson, C Bergh, O Yoluk, E Lindahl Bioinformatics 35 (18), 3505-3507, 2019 | 15 | 2019 |
| Convergence of EGFR glioblastoma mutations: evolution and allostery rationalizing targeted therapy L Orellana Molecular & cellular oncology 6 (5), e1630798, 2019 | 8 | 2019 |
| Oncogenic mutations of the EGF-Receptor ectodomain reveal an unexpected mechanism for ligand-independent activation L Orellana, A Hospital, M Orozco biorXiv, 2014 | 6 | 2014 |
| Are Protein Shape-Encoded Lowest-Frequency Motions a Key Phenotype Selected by Evolution? L Orellana Applied Sciences 13 (11), 6756, 2023 | 3 | 2023 |
| Exploring the Conformational Impact of Glycine Receptor TM1-2 Mutations Through Coarse-Grained Analysis and Atomistic Simulations AR Mhashal, O Yoluk, L Orellana Frontiers in Molecular Biosciences 9, 890851, 2022 | 3 | 2022 |
Erik LindahlProfessor of Biophysics, Linköping UniversityVerified email at liu.se
