H.S. Overkleeft
H.S. Overkleeft
Professor of Bio-organic Synthesis, Leiden University
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Proteasome inhibitors: an expanding army attacking a unique target
AF Kisselev, WA van der Linden, HS Overkleeft
Chemistry & biology 19 (1), 99-115, 2012
A novel active site‐directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14
A Borodovsky, BM Kessler, R Casagrande, HS Overkleeft, KD Wilkinson, ...
The EMBO journal, 2001
Thioglycosides in sequential glycosylation strategies
JDC Codée, REJN Litjens, LJ van den Bos, HS Overkleeft, ...
Chemical Society Reviews 34 (9), 769-782, 2005
Intracellular bacterial growth is controlled by a kinase network around PKB/AKT1
C Kuijl, NDL Savage, M Marsman, AW Tuin, L Janssen, DA Egan, ...
Nature 450 (7170), 725-730, 2007
Glycosphingolipids—nature, function, and pharmacological modulation
T Wennekes, RJ van den Berg, RG Boot, GA van der Marel, HS Overkleeft, ...
Angewandte Chemie International Edition 48 (47), 8848-8869, 2009
Pharmacological inhibition of glucosylceramide synthase enhances insulin sensitivity
JM Aerts, R Ottenhoff, AS Powlson, A Grefhorst, M Van Eijk, ...
Diabetes 56 (5), 1341-1349, 2007
Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474
ACM van Esbroeck, APA Janssen, AB Cognetta III, D Ogasawara, ...
Science 356 (6342), 1084-1087, 2017
Elevated plasma glucosylsphingosine in Gaucher disease: relation to phenotype, storage cell markers, and therapeutic response
N Dekker, L van Dussen, CEM Hollak, H Overkleeft, S Scheij, ...
Blood, The Journal of the American Society of Hematology 118 (16), e118-e127, 2011
Ultrasensitive in situ visualization of active glucocerebrosidase molecules
MD Witte, WW Kallemeijn, J Aten, KY Li, A Strijland, WE Donker-Koopman, ...
Nature chemical biology 6 (12), 907-913, 2010
Ph2SO/Tf2O:  a Powerful Promotor System in Chemoselective Glycosylations Using Thioglycosides
JDC Codée, REJN Litjens, R den Heeten, HS Overkleeft, JH van Boom, ...
Organic letters 5 (9), 1519-1522, 2003
Analysis of protease activity in live antigen-presenting cells shows regulation of the phagosomal proteolytic contents during dendritic cell activation
AM Lennon-Duménil, AH Bakker, R Maehr, E Fiebiger, HS Overkleeft, ...
The Journal of experimental medicine 196 (4), 529-540, 2002
Generation of specific deoxynojirimycin-type inhibitors of the non-lysosomal glucosylceramidase
HS Overkleeft, GH Renkema, J Neele, P Vianello, IO Hung, A Strijland, ...
Journal of Biological Chemistry 273 (41), 26522-26527, 1998
Muscle wasting in aged, sarcopenic rats is associated with enhanced activity of the ubiquitin proteasome pathway
M Altun, HC Besche, HS Overkleeft, R Piccirillo, MJ Edelmann, ...
Journal of Biological Chemistry 285 (51), 39597-39608, 2010
The caspase-like sites of proteasomes, their substrate specificity, new inhibitors and substrates, and allosteric interactions with the trypsin-like sites
AF Kisselev, M Garcia-Calvo, HS Overkleeft, E Peterson, MW Pennington, ...
Journal of Biological Chemistry 278 (38), 35869-35877, 2003
Asymmetric proteasome segregation as a mechanism for unequal partitioning of the transcription factor T-bet during T lymphocyte division
JT Chang, ML Ciocca, I Kinjyo, VR Palanivel, CE McClurkin, CS DeJong, ...
Immunity 34 (4), 492-504, 2011
Discovery of an essential nucleotidylating activity associated with a newly delineated conserved domain in the RNA polymerase-containing protein of all nidoviruses
KC Lehmann, A Gulyaeva, JC Zevenhoven-Dobbe, GMC Janssen, ...
Nucleic acids research 43 (17), 8416-8434, 2015
A fluorescent broad-spectrum proteasome inhibitor for labeling proteasomes in vitro and in vivo
M Verdoes, BI Florea, V Menendez-Benito, CJ Maynard, MD Witte, ...
Chemistry & biology 13 (11), 1217-1226, 2006
Identification of the non-lysosomal glucosylceramidase as β-glucosidase 2
RG Boot, M Verhoek, W Donker-Koopman, A Strijland, J van Marle, ...
Journal of Biological Chemistry 282 (2), 1305-1312, 2007
Distinct uptake mechanisms but similar intracellular processing of two different toll-like receptor ligand-peptide conjugates in dendritic cells
S Khan, MS Bijker, JJ Weterings, HJ Tanke, GJ Adema, T van Hall, ...
Journal of Biological Chemistry 282 (29), 21145-21159, 2007
Chemistry in living cells: detection of active proteasomes by a two-step labeling strategy
H Ovaa, PF Van Swieten, BM Kessler, MA Leeuwenburgh, E Fiebiger, ...
Angewandte Chemie (International ed. in English) 42 (31), 3626-3629, 2003
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