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Chandra Sekhar Mandava
Chandra Sekhar Mandava
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The ribosomal stalk binds to translation factors IF2, EF-Tu, EF-G and RF3 via a conserved region of the L12 C-terminal domain
M Helgstrand, CS Mandava, FAA Mulder, A Liljas, S Sanyal, M Akke
Journal of molecular biology 365 (2), 468-479, 2007
1442007
Structural and functional insights into the mode of action of a universally conserved Obg GTPase
B Feng, CS Mandava, Q Guo, J Wang, W Cao, N Li, Y Zhang, Y Zhang, ...
PLoS biology 12 (5), e1001866, 2014
1372014
HflX is a ribosome-splitting factor rescuing stalled ribosomes under stress conditions
Y Zhang, CS Mandava, W Cao, X Li, D Zhang, N Li, Y Zhang, X Zhang, ...
Nature structural & molecular biology 22 (11), 906-913, 2015
992015
A single-step method for purification of active His-tagged ribosomes from a genetically engineered Escherichia coli
J Ederth, CS Mandava, S Dasgupta, S Sanyal
Nucleic acids research 37 (2), e15-e15, 2009
922009
The ribosomal stalk plays a key role in IF2-mediated association of the ribosomal subunits
C Huang, CS Mandava, S Sanyal
Journal of molecular biology 399 (1), 145-153, 2010
592010
Bacterial ribosome requires multiple L12 dimers for efficient initiation and elongation of protein synthesis involving IF2 and EF-G
CS Mandava, K Peisker, J Ederth, R Kumar, X Ge, W Szaflarski, S Sanyal
Nucleic Acids Research 40 (5), 2054-2064, 2012
492012
Cryo-EM shows stages of initial codon selection on the ribosome by aa-tRNA in ternary complex with GTP and the GTPase-deficient EF-TuH84A
M Fislage, J Zhang, ZP Brown, CS Mandava, S Sanyal, M Ehrenberg, ...
Nucleic Acids Research 46 (11), 5861-5874, 2018
402018
Ribosomes lacking protein S20 are defective in mRNA binding and subunit association
C Tobin, CS Mandava, M Ehrenberg, DI Andersson, S Sanyal
Journal of molecular biology 397 (3), 767-776, 2010
362010
Repurposing tRNAs for nonsense suppression
S Albers, B Beckert, MC Matthies, CS Mandava, R Schuster, C Seuring, ...
Nature Communications 12 (1), 3850, 2021
342021
Structure and function of FusB: an elongation factor G-binding fusidic acid resistance protein active in ribosomal translocation and recycling
X Guo, K Peisker, K Bäckbro, Y Chen, RK Koripella, CS Mandava, ...
Open biology 2 (3), 120016, 2012
342012
A conserved histidine in switch-II of EF-G moderates release of inorganic phosphate
RK Koripella, M Holm, D Dourado, CS Mandava, S Flores, S Sanyal
Scientific reports 5 (1), 12970, 2015
322015
Micrococcin P1–A bactericidal thiopeptide active against Mycobacterium tuberculosis
G Degiacomi, Y Personne, G Mondésert, X Ge, CS Mandava, ...
Tuberculosis 100, 95-101, 2016
302016
Loss of a single methylation in 23S rRNA delays 50S assembly at multiple late stages and impairs translation initiation and elongation
W Wang, W Li, X Ge, K Yan, CS Mandava, S Sanyal, N Gao
Proceedings of the National Academy of Sciences 117 (27), 15609-15619, 2020
292020
Regulation of PfEMP1–VAR2CSA translation by a Plasmodium translation-enhancing factor
S Chan, A Frasch, CS Mandava, JH Ch'Ng, MP Quintana, M Vesterlund, ...
Nature microbiology 2 (7), 1-11, 2017
282017
Complementary charge-based interaction between the ribosomal-stalk protein L7/12 and IF2 is the key to rapid subunit association
X Ge, CS Mandava, C Lind, J Åqvist, S Sanyal
Proceedings of the National Academy of Sciences 115 (18), 4649-4654, 2018
232018
The mechanism of error induction by the antibiotic viomycin provides insight into the fidelity mechanism of translation
M Holm, CS Mandava, M Ehrenberg, S Sanyal
Elife 8, e46124, 2019
132019
Mechanistic insights into translation inhibition by aminoglycoside antibiotic arbekacin
NP Parajuli, CS Mandava, MY Pavlov, S Sanyal
Nucleic Acids Research 49 (12), 6880-6892, 2021
102021
Insights into translocation mechanism and ribosome evolution from cryo-EM structures of translocation intermediates of Giardia intestinalis
S Majumdar, A Emmerich, S Krakovka, CS Mandava, SG Svärd, S Sanyal
Nucleic acids research 51 (7), 3436-3451, 2023
52023
Optimization of a fluorescent-mRNA based real-time assay for precise kinetic measurements of ribosomal translocation
C Kim, M Holm, CS Mandava, S Sanyal
RNA biology 18 (12), 2363-2375, 2021
52021
Antibiotic thermorubin tethers ribosomal subunits and impedes A-site interactions to perturb protein synthesis in bacteria
NP Parajuli, A Emmerich, CS Mandava, MY Pavlov, S Sanyal
Nature Communications 14 (1), 918, 2023
32023
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