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Crispin Hiley
Crispin Hiley
Senior Lecturer, University College London
Dirección de correo verificada de ucl.ac.uk
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Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade
N McGranahan, AJS Furness, R Rosenthal, S Ramskov, R Lyngaa, ...
Science 351 (6280), 1463-1469, 2016
29282016
Tracking the evolution of non–small-cell lung cancer
M Jamal-Hanjani, GA Wilson, N McGranahan, NJ Birkbak, TBK Watkins, ...
New England Journal of Medicine 376 (22), 2109-2121, 2017
21442017
Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution
C Abbosh, NJ Birkbak, GA Wilson, M Jamal-Hanjani, T Constantin, ...
Nature 545 (7655), 446-451, 2017
16712017
Allele-specific HLA loss and immune escape in lung cancer evolution
N McGranahan, R Rosenthal, CT Hiley, AJ Rowan, TBK Watkins, ...
Cell 171 (6), 1259-1271. e11, 2017
11392017
Neoantigen-directed immune escape in lung cancer evolution
R Rosenthal, EL Cadieux, R Salgado, MA Bakir, DA Moore, CT Hiley, ...
Nature 567 (7749), 479-485, 2019
7142019
Fc effector function contributes to the activity of human anti-CTLA-4 antibodies
FA Vargas, AJS Furness, K Litchfield, K Joshi, R Rosenthal, E Ghorani, ...
Cancer cell 33 (4), 649-663. e4, 2018
5312018
Fc-optimized anti-CD25 depletes tumor-infiltrating regulatory T cells and synergizes with PD-1 blockade to eradicate established tumors
FA Vargas, AJS Furness, I Solomon, K Joshi, L Mekkaoui, MH Lesko, ...
Immunity 46 (4), 577-586, 2017
4092017
Geospatial immune variability illuminates differential evolution of lung adenocarcinoma
K AbdulJabbar, SEA Raza, R Rosenthal, M Jamal-Hanjani, S Veeriah, ...
Nature medicine 26 (7), 1054-1062, 2020
2232020
Deciphering intratumor heterogeneity and temporal acquisition of driver events to refine precision medicine
C Hiley, EC de Bruin, N McGranahan, C Swanton
Genome biology 15, 1-10, 2014
2222014
Pulmonary venous circulating tumor cell dissemination before tumor resection and disease relapse
F Chemi, DG Rothwell, N McGranahan, S Gulati, C Abbosh, SP Pearce, ...
Nature medicine 25 (10), 1534-1539, 2019
1682019
Spatial heterogeneity of the T cell receptor repertoire reflects the mutational landscape in lung cancer
K Joshi, MR de Massy, M Ismail, JL Reading, I Uddin, A Woolston, ...
Nature medicine 25 (10), 1549-1559, 2019
1642019
Challenges in molecular testing in non-small-cell lung cancer patients with advanced disease
CT Hiley, J Le Quesne, G Santis, R Sharpe, DG de Castro, G Middleton, ...
The Lancet 388 (10048), 1002-1011, 2016
1582016
Determinants of anti-PD-1 response and resistance in clear cell renal cell carcinoma
L Au, E Hatipoglu, MR de Massy, K Litchfield, G Beattie, A Rowan, ...
Cancer cell 39 (11), 1497-1518. e11, 2021
1482021
Pitfalls in assessing stromal tumor infiltrating lymphocytes (sTILs) in breast cancer
Z Kos, E Roblin, RS Kim, S Michiels, BD Gallas, W Chen, KK van de Vijver, ...
NPJ breast cancer 6 (1), 17, 2020
1262020
Expression of vascular endothelial growth factor (VEGF) in locally invasive prostate cancer is prognostic for radiotherapy outcome
MML Green, CT Hiley, JH Shanks, IC Bottomley, CML West, RA Cowan, ...
International Journal of Radiation Oncology* Biology* Physics 67 (1), 84-90, 2007
1082007
A clonal expression biomarker associates with lung cancer mortality
D Biswas, NJ Birkbak, R Rosenthal, CT Hiley, EL Lim, K Papp, S Boeing, ...
Nature medicine 25 (10), 1540-1548, 2019
862019
The T cell differentiation landscape is shaped by tumour mutations in lung cancer
E Ghorani, JL Reading, JY Henry, MR Massy, R Rosenthal, V Turati, ...
Nature cancer 1 (5), 546-561, 2020
852020
PRSS3 promotes tumour growth and metastasis of human pancreatic cancer
G Jiang, F Cao, G Ren, D Gao, V Bhakta, Y Zhang, H Cao, Z Dong, ...
Gut 59 (11), 1535-1544, 2010
832010
The evolution of lung cancer and impact of subclonal selection in TRACERx
AM Frankell, M Dietzen, M Al Bakir, EL Lim, T Karasaki, S Ward, ...
Nature 616 (7957), 525-533, 2023
732023
Antibodies against endogenous retroviruses promote lung cancer immunotherapy
KW Ng, J Boumelha, KSS Enfield, J Almagro, H Cha, O Pich, T Karasaki, ...
Nature 616 (7957), 563-573, 2023
732023
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