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Jeffrey Holt
Jeffrey Holt
Professor, Harvard Medical School / Boston Children's Hospital
Verified email at childrens.harvard.edu - Homepage
Title
Cited by
Cited by
Year
TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells
DP Corey, J García-Añoveros, JR Holt, KY Kwan, SY Lin, MA Vollrath, ...
Nature 432 (7018), 723-730, 2004
8822004
Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents
X Gao, Y Tao, V Lamas, M Huang, WH Yeh, B Pan, YJ Hu, JH Hu, ...
Nature 553 (7687), 217-221, 2018
5302018
Mechanotransduction in mouse inner ear hair cells requires transmembrane channel–like genes
Y Kawashima, GSG Géléoc, K Kurima, V Labay, A Lelli, Y Asai, ...
The Journal of clinical investigation 121 (12), 4796-4809, 2011
3972011
TMC1 and TMC2 are components of the mechanotransduction channel in hair cells of the mammalian inner ear
B Pan, GS Géléoc, Y Asai, GC Horwitz, K Kurima, K Ishikawa, ...
Neuron 79 (3), 504-515, 2013
3952013
Differential distribution of stem cells in the auditory and vestibular organs of the inner ear
K Oshima, CM Grimm, CE Corrales, P Senn, R Martinez Monedero, ...
Journal of the Association for Research in Otolaryngology 8, 18-31, 2007
3882007
A chemical-genetic strategy implicates myosin-1c in adaptation by hair cells
JR Holt, SKH Gillespie, DW Provance, K Shah, KM Shokat, DP Corey, ...
Cell 108 (3), 371-381, 2002
3792002
Continuous evolution of base editors with expanded target compatibility and improved activity
BW Thuronyi, LW Koblan, JM Levy, WH Yeh, C Zheng, GA Newby, ...
Nature biotechnology 37 (9), 1070-1079, 2019
3312019
Calcium imaging of single stereocilia in hair cells: localization of transduction channels at both ends of tip links
W Denk, JR Holt, GMG Shepherd, DP Corey
Neuron 15 (6), 1311-1321, 1995
3201995
A synthetic AAV vector enables safe and efficient gene transfer to the mammalian inner ear
LD Landegger, B Pan, C Askew, SJ Wassmer, SD Gluck, A Galvin, ...
Nature biotechnology 35 (3), 280-284, 2017
3072017
Gene therapy restores auditory and vestibular function in a mouse model of Usher syndrome type 1c
B Pan, C Askew, A Galvin, S Heman-Ackah, Y Asai, AA Indzhykulian, ...
Nature biotechnology 35 (3), 264-272, 2017
2792017
Generation of inner ear organoids containing functional hair cells from human pluripotent stem cells
KR Koehler, J Nie, E Longworth-Mills, XP Liu, J Lee, JR Holt, E Hashino
Nature biotechnology 35 (6), 583-589, 2017
2752017
TMC1 forms the pore of mechanosensory transduction channels in vertebrate inner ear hair cells
B Pan, N Akyuz, XP Liu, Y Asai, C Nist-Lund, K Kurima, BH Derfler, ...
Neuron 99 (4), 736-753. e6, 2018
2712018
Sound strategies for hearing restoration
GSG Géléoc, JR Holt
Science 344 (6184), 1241062, 2014
2412014
The very large G-protein-coupled receptor VLGR1: a component of the ankle link complex required for the normal development of auditory hair bundles
JA McGee, RJ Goodyear, DR McMillan, EA Stauffer, JR Holt, KG Locke, ...
Journal of Neuroscience 26 (24), 6543-6553, 2006
2322006
Tonotopic gradient in the developmental acquisition of sensory transduction in outer hair cells of the mouse cochlea
A Lelli, Y Asai, A Forge, JR Holt, GSG Géléoc
Journal of neurophysiology 101 (6), 2961-2973, 2009
1742009
Allele-specific gene editing prevents deafness in a model of dominant progressive hearing loss
B György, C Nist-Lund, B Pan, Y Asai, KD Karavitaki, BP Kleinstiver, ...
Nature medicine 25 (7), 1123-1130, 2019
1722019
TMC1 and TMC2 localize at the site of mechanotransduction in mammalian inner ear hair cell stereocilia
K Kurima, S Ebrahim, B Pan, M Sedlacek, P Sengupta, BA Millis, R Cui, ...
Cell reports 12 (10), 1606-1617, 2015
1722015
Physical and functional interaction between protocadherin 15 and myosin VIIa in mechanosensory hair cells
M Senften, M Schwander, P Kazmierczak, C Lillo, JB Shin, T Hasson, ...
Journal of Neuroscience 26 (7), 2060-2071, 2006
1682006
Fast adaptation in vestibular hair cells requires myosin-1c activity
EA Stauffer, JD Scarborough, M Hirono, ED Miller, K Shah, JA Mercer, ...
Neuron 47 (4), 541-553, 2005
1632005
Developmental acquisition of sensory transduction in hair cells of the mouse inner ear
GSG Géléoc, JR Holt
Nature neuroscience 6 (10), 1019-1020, 2003
1612003
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