| Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth R Castonguay, ED Werner, RG Matthews, E Presman, AW Mulivor, ... Journal of Biological Chemistry 286 (34), 30034-30046, 2011 | 256 | 2011 |
| Characterization of the ligand binding functionality of the extracellular domain of activin receptor type IIb D Sako, AV Grinberg, J Liu, MV Davies, R Castonguay, S Maniatis, ... Journal of Biological Chemistry 285 (27), 21037-21048, 2010 | 227 | 2010 |
| ALK1-Fc inhibits multiple mediators of angiogenesis and suppresses tumor growth D Mitchell, EG Pobre, AW Mulivor, AV Grinberg, R Castonguay, ... Molecular cancer therapeutics 9 (2), 379-388, 2010 | 203 | 2010 |
| Gamma‐glutamyl transpeptidase substrate specificity and catalytic mechanism JW Keillor, R Castonguay, C Lherbet Methods in enzymology 401, 449-467, 2005 | 126 | 2005 |
| Stereospecificity of ketoreductase domains of the 6-deoxyerythronolide B synthase R Castonguay, W He, AY Chen, C Khosla, DE Cane Journal of the American Chemical Society 129 (44), 13758-13769, 2007 | 101 | 2007 |
| Stereospecificity of ketoreductase domains 1 and 2 of the tylactone modular polyketide synthase R Castonguay, CR Valenzano, AY Chen, A Keatinge-Clay, C Khosla, ... Journal of the American Chemical Society 130 (35), 11598-11599, 2008 | 54 | 2008 |
| Structural characterization of an activin class ternary receptor complex reveals a third paradigm for receptor specificity EJ Goebel, RA Corpina, CS Hinck, M Czepnik, R Castonguay, R Grenha, ... Proceedings of the National Academy of Sciences 116 (31), 15505-15513, 2019 | 52 | 2019 |
| Kinetic characterization and identification of the acylation and glycosylation sites of recombinant human γ-glutamyltranspeptidase R Castonguay, D Halim, M Morin, A Furtos, C Lherbet, E Bonneil, ... Biochemistry 46 (43), 12253-12262, 2007 | 43 | 2007 |
| Follistatin-based ligand trap ACE-083 induces localized hypertrophy of skeletal muscle with functional improvement in models of neuromuscular disease RS Pearsall, MV Davies, M Cannell, J Li, J Widrick, AW Mulivor, S Wallner, ... Scientific Reports 9 (1), 11392, 2019 | 40 | 2019 |
| De novo helical peptides as target sequences for a specific, fluorogenic protein labelling strategy J Guy, R Castonguay, NBCR Pineda, V Jacquier, K Caron, SW Michnick, ... Molecular BioSystems 6 (6), 976-987, 2010 | 40 | 2010 |
| Kinetic studies of rat kidney γ-glutamyltranspeptidase deacylation reveal a general base-catalyzed mechanism R Castonguay, C Lherbet, JW Keillor Biochemistry 42 (39), 11504-11513, 2003 | 33 | 2003 |
| Nonlinear free energy relationship in the general-acid-catalyzed acylation of rat kidney γ-glutamyl transpeptidase by a series of γ-glutamyl anilide substrate analogues A Ménard, R Castonguay, C Lherbet, C Rivard, Y Roupioz, JW Keillor Biochemistry 40 (42), 12678-12685, 2001 | 32 | 2001 |
| Sotatercept analog suppresses inflammation to reverse experimental pulmonary arterial hypertension SR Joshi, J Liu, T Bloom, E Karaca Atabay, TH Kuo, M Lee, E Belcheva, ... Scientific reports 12 (1), 7803, 2022 | 30 | 2022 |
| Follistatin-288-Fc fusion protein promotes localized growth of skeletal muscle R Castonguay, J Lachey, S Wallner, J Strand, K Liharska, AE Watanabe, ... Journal of Pharmacology and Experimental Therapeutics 368 (3), 435-445, 2019 | 29 | 2019 |
| Pre‐steady‐state kinetic studies of rat kidney γ‐glutamyl transpeptidase confirm its ping‐pong mechanism JW Keillor, A Menard, R Castonguay, C Lherbet, C Rivard Journal of physical organic chemistry 17 (6‐7), 529-536, 2004 | 28 | 2004 |
| TGF-beta superfamily type I and type II receptor heteromultimers and uses thereof R Kumar, A Grinberg, D Sako, RS Pearsall, R Castonguay US Patent 10,227,393, 2019 | 27 | 2019 |
| Mapping of the active site of rat kidney γ-glutamyl transpeptidase using activated esters and their amide derivatives R Castonguay, C Lherbet, JW Keillor Bioorganic & medicinal chemistry 10 (12), 4185-4191, 2002 | 25 | 2002 |
| The orphan ligand, activin C, signals through activin receptor-like kinase 7 EJ Goebel, L Ongaro, EC Kappes, K Vestal, E Belcheva, R Castonguay, ... Elife 11, e78197, 2022 | 23 | 2022 |
| ActRIIB: ALK4-Fc alleviates muscle dysfunction and comorbidities in murine models of neuromuscular disorders J Li, M Fredericks, M Cannell, K Wang, D Sako, MC Maguire, R Grenha, ... The Journal of clinical investigation 131 (4), 2021 | 21 | 2021 |
| ALK4: ActRIIB heteromultimers and uses thereof R Kumar, A Grinberg, D Sako, RS Pearsall, R Castonguay US Patent 10,196,434, 2019 | 20 | 2019 |
