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George R. Heaton
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Back to the tubule: microtubule dynamics in Parkinson’s disease
L Pellegrini, A Wetzel, S Grannó, G Heaton, K Harvey
Cellular and Molecular Life Sciences 74, 409-434, 2017
1382017
LRRK2 Biology from structure to dysfunction: research progresses, but the themes remain the same
DC Berwick, GR Heaton, S Azeggagh, K Harvey
Molecular Neurodegeneration 14, 1-22, 2019
1352019
Proteomic analysis reveals co-ordinated alterations in protein synthesis and degradation pathways in LRRK2 knockout mice
L Pellegrini, DN Hauser, Y Li, A Mamais, A Beilina, R Kumaran, A Wetzel, ...
Human molecular genetics 27 (18), 3257-3271, 2018
612018
Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia
A Mamais, JH Kluss, L Bonet-Ponce, N Landeck, RG Langston, N Smith, ...
PLoS biology 19 (12), e3001480, 2021
512021
Progress in LRRK2-associated Parkinson’s disease animal models
SP Seegobin, GR Heaton, D Liang, I Choi, M Blanca Ramirez, B Tang, ...
Frontiers in Neuroscience 14, 539964, 2020
372020
Sequential screening nominates the Parkinson's disease associated kinase LRRK2 as a regulator of Clathrin-mediated endocytosis
GR Heaton, N Landeck, A Mamais, MA Nalls, J Nixon-Abell, R Kumaran, ...
Neurobiology of disease 141, 104948, 2020
292020
Downregulated Wnt/β-catenin signalling in the Down syndrome hippocampus
S Granno, J Nixon-Abell, DC Berwick, J Tosh, G Heaton, S Almudimeegh, ...
Scientific reports 9 (1), 7322, 2019
292019
Ocular biomarkers of Alzheimer’s disease
G R Heaton, B M Davis, L A Turner, M F Cordeiro
Central Nervous System Agents in Medicinal Chemistry (Formerly Current …, 2015
212015
Regulation of α-synuclein homeostasis and inflammasome activation by microglial autophagy
I Choi, GR Heaton, YK Lee, Z Yue
Science advances 8 (43), eabn1298, 2022
152022
Circulating senescent myeloid cells infiltrate the brain and cause neurodegeneration in histiocytic disorders
CM Wilk, F Cathomas, O Török, J Le Berichel, MD Park, C Bigenwald, ...
Immunity 56 (12), 2790-2802. e6, 2023
32023
Circulating senescent myeloid cells drive blood brain barrier breakdown and neurodegeneration
CM Wilk, F Cathomas, O Torok, J Le Berichel, MD Park, GR Heaton, ...
bioRxiv, 2023.10. 10.561744, 2023
12023
Correction: Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia
A Mamais, JH Kluss, L Bonet-Ponce, N Landeck, RG Langston, N Smith, ...
Plos Biology 20 (5), e3001621, 2022
12022
Bone Marrow-Derived BRAFV600E-Mutated Cells Drive Neurodegeneration in a Mouse Model of Langerhans Cell Histiocytosis
CM Wilk, J LeBerichel, F Cathomas, G Heaton, O Török, A Silvin, Z Yue, ...
Blood 140 (Supplement 1), 3873-3873, 2022
2022
Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia (vol 19, 3001480, 2021)
A Mamais, JH Kluss, L Bonet-Ponce, N Landeck, RG Langston, N Smith, ...
PLOS BIOLOGY 20 (5), 2022
2022
Investigating vesicular trafficking function and dysfunction of the Parkinson’s Disease kinase LRRK2
G Heaton
UCL (University College London), 2019
2019
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Articles 1–15