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Helen Walden
Helen Walden
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PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65
C Kondapalli, A Kazlauskaite, N Zhang, HI Woodroof, DG Campbell, ...
Open biology 2 (5), 120080, 2012
9892012
Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases
M Zhuang, MF Calabrese, J Liu, MB Waddell, A Nourse, M Hammel, ...
Molecular cell 36 (1), 39-50, 2009
5092009
Types of ubiquitin ligases
FE Morreale, H Walden
Cell 165 (1), 248-248. e1, 2016
4792016
Autoregulation of Parkin activity through its ubiquitin‐like domain
VK Chaugule, L Burchell, KR Barber, A Sidhu, SJ Leslie, GS Shaw, ...
The EMBO journal 30 (14), 2853-2867, 2011
3772011
The CCP4 suite: integrative software for macromolecular crystallography
J Agirre, M Atanasova, H Bagdonas, CB Ballard, A Baslé, ...
Acta Crystallographica Section D: Structural Biology 79 (6), 449-461, 2023
3752023
RBR E3 ubiquitin ligases: new structures, new insights, new questions
DE Spratt, H Walden, GS Shaw
Biochemical journal 458 (3), 421-437, 2014
3672014
Ubiquitin signalling in DNA replication and repair
HD Ulrich, H Walden
Nature reviews Molecular cell biology 11 (7), 479-489, 2010
3502010
The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1
H Walden, MS Podgorski, DT Huang, DW Miller, RJ Howard, DL Minor, ...
Molecular cell 12 (6), 1427-1437, 2003
3192003
The Fanconi anemia DNA repair pathway: structural and functional insights into a complex disorder
H Walden, AJ Deans
Annual review of biophysics 43 (1), 257-278, 2014
2842014
Hydrophobic, aromatic, and electrostatic interactions play a central role in amyloid fibril formation and stability
KE Marshall, KL Morris, D Charlton, N O’Reilly, L Lewis, H Walden, ...
Biochemistry 50 (12), 2061-2071, 2011
2602011
Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8
H Walden, MS Podgorski, BA Schulman
Nature 422 (6929), 330-334, 2003
2582003
Binding to serine 65‐phosphorylated ubiquitin primes Parkin for optimal PINK 1‐dependent phosphorylation and activation
A Kazlauskaite, RJ Martínez‐Torres, S Wilkie, A Kumar, J Peltier, ...
EMBO reports 16 (8), 939-954, 2015
2522015
Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis
A Kumar, JD Aguirre, TEC Condos, RJ Martinez‐Torres, VK Chaugule, ...
The EMBO journal 34 (20), 2506-2521, 2015
2012015
Lack of prominent peptide–major histocompatibility complex features limits repertoire diversity in virus-specific CD8+ T cell populations
SJ Turner, K Kedzierska, H Komodromou, NL La Gruta, MA Dunstone, ...
Nature immunology 6 (4), 382-389, 2005
1792005
Tiny TIM: a small, tetrameric, hyperthermostable triosephosphate isomerase
H Walden, GS Bell, RJM Russell, B Siebers, R Hensel, GL Taylor
Journal of molecular biology 306 (4), 745-757, 2001
1622001
RBR ligase–mediated ubiquitin transfer: a tale with many twists and turns
H Walden, K Rittinger
Nature structural & molecular biology 25 (6), 440-445, 2018
1522018
A molecular explanation for the recessive nature of parkin-linked Parkinson’s disease
DE Spratt, R Julio Martinez-Torres, YJ Noh, P Mercier, N Manczyk, ...
Nature communications 4 (1), 1983, 2013
1422013
Selenium incorporation using recombinant techniques
H Walden
Acta Crystallographica Section D: Biological Crystallography 66 (4), 352-357, 2010
1192010
Ubiquitin-like protein activation
DT Huang, H Walden, D Duda, BA Schulman
Oncogene 23 (11), 1958-1971, 2004
1182004
Parkin–phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase activity
A Kumar, VK Chaugule, TEC Condos, KR Barber, C Johnson, R Toth, ...
Nature structural & molecular biology 24 (5), 475-483, 2017
1132017
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Artículos 1–20