| FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation MM Gaschler, AA Andia, H Liu, JM Csuka, B Hurlocker, CA Vaiana, ... Nature chemical biology 14 (5), 507-515, 2018 | 561 | 2018 |
| Multivalent small-molecule pan-RAS inhibitors ME Welsch, A Kaplan, JM Chambers, ME Stokes, PH Bos, A Zask, ... Cell 168 (5), 878-889. e29, 2017 | 259 | 2017 |
| Catalytic asymmetric conjugate addition/oxidative dearomatization towards multifunctional spirocyclic compounds A Rudolph, PH Bos, A Meetsma, AJ Minnaard, BL Feringa Angewandte Chemie-International Edition 50 (26), 5834-5838, 2011 | 135 | 2011 |
| Catalytic asymmetric carbon–carbon bond formation via allylic alkylations with organolithium compounds M Pérez, M Fañanás-Mastral, PH Bos, A Rudolph, SR Harutyunyan, ... Nature chemistry 3 (5), 377-381, 2011 | 113 | 2011 |
| Reaction-based enumeration, active learning, and free energy calculations to rapidly explore synthetically tractable chemical space and optimize potency of cyclin-dependent … KD Konze, PH Bos, MK Dahlgren, K Leswing, I Tubert-Brohman, ... Journal of chemical information and modeling 59 (9), 3782-3793, 2019 | 103 | 2019 |
| Enantioselective Synthesis of Tertiary and Quaternary Stereogenic Centers: Copper/Phosphoramidite‐Catalyzed Allylic Alkylation with Organolithium Reagents M Fañanás‐Mastral, M Pérez, PH Bos, A Rudolph, SR Harutyunyan, ... Angewandte Chemie International Edition 51 (8), 1922-1925, 2012 | 80 | 2012 |
| Copper-catalyzed asymmetric ring opening of oxabicyclic alkenes with organolithium reagents PH Bos, A Rudolph, M Perez, M Fañanás-Mastral, SR Harutyunyan, ... Chemical communications 48 (12), 1748-1750, 2012 | 80 | 2012 |
| Copper-binding small molecule induces oxidative stress and cell-cycle arrest in glioblastoma-patient-derived cells K Shimada, E Reznik, ME Stokes, L Krishnamoorthy, PH Bos, Y Song, ... Cell chemical biology 25 (5), 585-594. e7, 2018 | 74 | 2018 |
| Catalytic asymmetric conjugate addition of grignard reagents to alpha, beta-unsaturated sulfones. PH Bos, AJ Minnaard, BL Feringa Organic letters 10 (19), 4219-4222, 2008 | 74 | 2008 |
| Catalytic asymmetric conjugate addition of dialkylzinc reagents to α, β-unsaturated sulfones PH Bos, B Maciá, MA Fernández-Ibánez, AJ Minnaard, BL Feringa Organic & Biomolecular Chemistry 8 (1), 47-49, 2010 | 52 | 2010 |
| Development of MAP4 kinase inhibitors as motor neuron-protecting agents PH Bos, ER Lowry, J Costa, S Thams, A Garcia-Diaz, A Zask, H Wichterle, ... Cell chemical biology 26 (12), 1703-1715. e37, 2019 | 44 | 2019 |
| Tandem dienone photorearrangement–cycloaddition for the rapid generation of molecular complexity PH Bos, MT Antalek, JA Porco Jr, CRJ Stephenson Journal of the American Chemical Society 135 (47), 17978-17982, 2013 | 41 | 2013 |
| Asymmetric allylic alkylation of acyclic allylic ethers with organolithium reagents M Perez, M Fananas-Mastral, V Hornillos, A Rudolph, PH Bos, ... Chemistry: a European Journal 18 (38), 11880-11883, 2012 | 41 | 2012 |
| K-RasG12D Has a Potential Allosteric Small Molecule Binding Site H Feng, Y Zhang, PH Bos, JM Chambers, MM Dupont, BR Stockwell Biochemistry 58 (21), 2542-2554, 2019 | 36 | 2019 |
| Combining cloud-based free-energy calculations, synthetically aware enumerations, and goal-directed generative machine learning for rapid large-scale chemical exploration and … P Ghanakota, PH Bos, KD Konze, J Staker, G Marques, K Marshall, ... Journal of Chemical Information and Modeling 60 (9), 4311-4325, 2020 | 35 | 2020 |
| Synthetic Study toward Total Synthesis of (±)-Germine: Synthesis of (±)-4-Methylenegermine G Stork, A Yamashita, RM Hanson, L Phan, E Phillips, D Dubé, PH Bos, ... Organic letters 19 (19), 5150-5153, 2017 | 17 | 2017 |
| AutoDesigner, a de novo design algorithm for rapidly exploring large chemical space for lead optimization: Application to the design and synthesis of d-amino acid oxidase … PH Bos, EM Houang, F Ranalli, AE Leffler, NA Boyles, VA Eyrich, Y Luria, ... Journal of Chemical Information and Modeling 62 (8), 1905-1915, 2022 | 13 | 2022 |
| Catalyst-controlled reverse selectivity in C–C bond formation: NHC-Cu-catalyzed α-selective allylic alkylation with organolithium reagents SF Pizzolato, M Giannerini, PH Bos, M Fañanás-Mastral, BL Feringa Chemical communications 51 (38), 8142-8145, 2015 | 12 | 2015 |
| Stereoselective synthesis of 2, 3, 7‐trimethylcyclooctanone and related compounds and determination of their relative and absolute configurations by the MαNP acid method J Naito, S Kuwahara, M Watanabe, J Decatur, PH Bos, ... Chirality: The Pharmacological, Biological, and Chemical Consequences of …, 2008 | 10 | 2008 |
| Impacting drug discovery projects with large-scale enumerations, machine learning strategies, and free-energy predictions JL Knight, K Leswing, PH Bos, L Wang Free Energy Methods in Drug Discovery: Current State and Future Directions …, 2021 | 7 | 2021 |
