| Combining native and ‘omics’ mass spectrometry to identify endogenous ligands bound to membrane proteins J Gault, I Liko, M Landreh, D Shutin, JR Bolla, D Jefferies, M Agasid, ... Nature methods 17 (5), 505-508, 2020 | 131 | 2020 |
| A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage MJGW Ladds, IMM Van Leeuwen, CJ Drummond, S Chu, AR Healy, ... Nature communications 9 (1), 1107, 2018 | 87 | 2018 |
| A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage MJGW Ladds, IMM Van Leeuwen, CJ Drummond, S Chu, AR Healy, ... Nature communications 9 (1), 1107, 2018 | 87 | 2018 |
| Tenovin-D3, a Novel Small-Molecule Inhibitor of Sirtuin SirT2, Increases p21 (CDKN1A) Expression in a p53-Independent Manner AR McCarthy, MCC Sachweh, M Higgins, J Campbell, CJ Drummond, ... Molecular cancer therapeutics 12 (4), 352-360, 2013 | 46 | 2013 |
| Small molecule activators of the p53 response MJGW Ladds, S Laín Journal of molecular cell biology 11 (3), 245-254, 2019 | 39 | 2019 |
| CD36 and LC3B initiated autophagy in B cells regulates the humoral immune response C He, S Wang, C Zhou, M He, J Wang, M Ladds, D Lianoudaki, ... Autophagy 17 (11), 3577-3591, 2021 | 33 | 2021 |
| Lipids shape the electron acceptor-binding site of the peripheral membrane protein dihydroorotate dehydrogenase J Costeira-Paulo, J Gault, G Popova, MJGW Ladds, IMM van Leeuwen, ... Cell chemical biology 25 (3), 309-317. e4, 2018 | 27 | 2018 |
| Autophagy suppresses the formation of hepatocyte-derived cancer-initiating ductular progenitor cells in the liver VJA Barthet, M Brucoli, MJGW Ladds, C Nössing, C Kiourtis, AD Baudot, ... Science Advances 7 (23), eabf9141, 2021 | 25 | 2021 |
| Optimization of tetrahydroindazoles as inhibitors of human dihydroorotate dehydrogenase and evaluation of their activity and in vitro metabolic stability G Popova, MJGW Ladds, L Johansson, A Saleh, J Larsson, L Sandberg, ... Journal of Medicinal Chemistry 63 (8), 3915-3934, 2020 | 16 | 2020 |
| DHODH inhibition modulates glucose metabolism and circulating GDF15, and improves metabolic balance J Zhang, G Teran, M Popa, H Madapura, MJGW Ladds, D Lianoudaki, ... Iscience 24 (5), 2021 | 12 | 2021 |
| Exploitation of dihydroorotate dehydrogenase (DHODH) and p53 activation as therapeutic targets: A case study in polypharmacology MJGW Ladds, G Popova, A Pastor-Fernández, S Kannan, ... Journal of Biological Chemistry 295 (52), 17935-17949, 2020 | 12 | 2020 |
| ATG7 is a haploinsufficient repressor of tumor progression and promoter of metastasis JS Long, E Kania, DG McEwan, VJA Barthet, M Brucoli, MJGW Ladds, ... Proceedings of the National Academy of Sciences 119 (28), e2113465119, 2022 | 9 | 2022 |
| Autophagic flux blockage by accumulation of weakly basic tenovins leads to elimination of B-Raf mutant tumour cells that survive vemurafenib MJGW Ladds, A Pastor-Fernandez, G Popova, IMM van Leeuwen, ... Plos one 13 (4), e0195956, 2018 | 5 | 2018 |
| Dihydroorotate dehydrogenase inhibition acts synergistically with tyrosine kinase inhibitors to induce apoptosis of mantle cell lymphoma cells M Eriksen‐Gjerstad, I Tveit Karlsen, Z Fandalyuk, S Benjaminsen, ... EJHaem 3 (3), 913-918, 2022 | 2 | 2022 |
| Publisher Correction: A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage MJGW Ladds, IMM van Leeuwen, CJ Drummond, S Chu, AR Healy, ... nature communications 14 (1), 5019, 2023 | 1 | 2023 |
| Enhanced Targeting of FLT3-ITD+ AML Stem Cells through Combined Inhibition of SIRT1 and Autophagic Flux S Chu, YT Hsieh, MJGW Ladds, S Lane, R Bhatia Blood 128 (22), 31, 2016 | 1 | 2016 |
| p53 Transcriptional Activity as a Tool to Uncover Novel and Diverse Druggable Targets in Cancer MJGW Ladds PQDT-Global, 2018 | | 2018 |
| Sirtuin inhibition by Tenovins disrupts microtubule dynamics and chromosome structure: potential use as antimitotic agents. M Carmena, O Molina, EM Peat, C Breunig, I van Leeuwen, M Ladds, ... MOLECULAR BIOLOGY OF THE CELL 27, 2016 | | 2016 |
| Tenovins function as antimitotic agents by disrupting microtubule cytoskeleton dynamics in mitosis M Carmena, C Breunig, O Molina-Campoy, I van Leeuwen, M Ladds, ... MOLECULAR BIOLOGY OF THE CELL 26, 2015 | | 2015 |
| Tenovin-treated cells show defects in mitosis and cytokinesis and tubulin cytoskeleton abnormalities in interphase. M Carmena, C Breunig, O Molina, I van Leeuwen, M Ladds, S Lain, ... MOLECULAR BIOLOGY OF THE CELL 25, 2014 | | 2014 |
David P LaneA*STARVerified email at p53lab.a-star.edu.sg
