Mauricio Morais
Mauricio Morais
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Functional native disulfide bridging enables delivery of a potent, stable and targeted antibody–drug conjugate (ADC)
JPM Nunes, M Morais, V Vassileva, E Robinson, VS Rajkumar, ...
Chemical Communications 51 (53), 10624-10627, 2015
A platform for efficient, thiol-stable conjugation to albumin's native single accessible cysteine
MEB Smith, MB Caspersen, E Robinson, M Morais, A Maruani, ...
Organic & biomolecular chemistry 13 (29), 7946-7949, 2015
New 99mTc(CO)3 Mannosylated Dextran Bearing S-Derivatized Cysteine Chelator for Sentinel Lymph Node Detection
I Pirmettis, Y Arano, T Tsotakos, K Okada, A Yamaguchi, T Uehara, ...
Molecular pharmaceutics 9 (6), 1681-1692, 2012
Mannosylated Dextran Derivatives Labeled with fac-[M(CO)3]+ (M = 99mTc, Re) for Specific Targeting of Sentinel Lymph Node
M Morais, S Subramanian, U Pandey, G Samuel, M Venkatesh, M Martins, ...
Molecular pharmaceutics 8 (2), 609-620, 2011
Optimisation of the dibromomaleimide (DBM) platform for native antibody conjugation by accelerated post-conjugation hydrolysis
M Morais, JPM Nunes, K Karu, N Forte, I Benni, MEB Smith, S Caddick, ...
Organic & Biomolecular Chemistry 15 (14), 2947-2952, 2017
Target-specific Tc(CO)3-complexes for in vivo imaging
M Morais, A Paulo, L Gano, I Santos, JDG Correia
Journal of Organometallic Chemistry 744, 125-139, 2013
Influence of the Bifunctional Chelator on the Pharmacokinetic Properties of 99mTc(CO)3-Labeled Cyclic α-Melanocyte Stimulating Hormone Analog
M Morais, BL Oliveira, JDG Correia, MC Oliveira, MA Jiménez, I Santos, ...
Journal of medicinal chemistry 56 (5), 1961-1973, 2013
Evaluation of novel 99mTc(I)-labeled homobivalent α-melanocyte-stimulating hormone analogs for melanocortin-1 receptor targeting
M Morais, PD Raposinho, MC Oliveira, JDG Correia, I Santos
JBIC Journal of Biological Inorganic Chemistry 17 (4), 491-505, 2012
Tuning the hydrolytic stability of next generation maleimide cross-linkers enables access to albumin-antibody fragment conjugates and tri-scFvs
N Forte, M Livanos, E Miranda, M Morais, X Yang, VS Rajkumar, ...
Bioconjugate chemistry 29 (2), 486-492, 2018
Site-specific chelator-antibody conjugation for PET and SPECT imaging with radiometals
M Morais, MT Ma
Drug Discovery Today: Technologies 30, 91-104, 2018
Radiolabeled mannosylated dextran derivatives bearing an NIR-fluorophore for sentinel lymph node imaging
M Morais, MPC Campello, C Xavier, J Heemskerk, JDG Correia, ...
Bioconjugate chemistry 25 (11), 1963-1970, 2014
Use of a next generation maleimide in combination with THIOMAB™ antibody technology delivers a highly stable, potent and near homogeneous THIOMAB™ antibody-drug conjugate (TDC)
JPM Nunes, V Vassileva, E Robinson, M Morais, MEB Smith, RB Pedley, ...
RSC advances 7 (40), 24828-24832, 2017
Biodistribution of a 67Ga-labeled anti-TNF VHH single-domain antibody containing a bacterial albumin-binding domain (Zag)
M Morais, C Cantante, L Gano, I Santos, S Lourenço, C Santos, C Fontes, ...
Nuclear medicine and biology 41, e44-e48, 2014
Albumin-binding domain from Streptococcus zooepidemicus protein Zag as a novel strategy to improve the half-life of therapeutic proteins
C Cantante, S Lourenço, M Morais, J Leandro, L Gano, N Silva, ...
Journal of biotechnology 253, 23-33, 2017
NMR Structural Analysis of MC1R-Targeted Rhenium(I) Metallopeptides and Biological Evaluation of 99mTc(I) Congeners
M Morais, PD Raposinho, MC Oliveira, D Pantoja-Uceda, MA Jiménez, ...
Organometallics 31 (16), 5929-5939, 2012
Novel peptides derived from Dengue virus capsid protein translocate reversibly the blood–brain barrier through a receptor-free mechanism
V Neves, F Aires-da-Silva, M Morais, L Gano, E Ribeiro, A Pinto, S Aguiar, ...
ACS Chemical Biology 12 (5), 1257-1268, 2017
Nonconventional trans‐Platinum Complexes Functionalized with RDG Peptides: Chemical and Cytototoxicity Studies
MA Medrano, M Morais, VFC Ferreira, JDG Correia, A Paulo, I Santos, ...
European Journal of Inorganic Chemistry 2017 (12), 1835-1840, 2017
Re (I) and Tc (I) complexes for targeting nitric oxide synthase: influence of the chelator in the affinity for the enzyme
BL Oliveira, M Morais, F Mendes, IS Moreira, C Cordeiro, PA Fernandes, ...
Chemical biology & drug design 86 (5), 1072-1086, 2015
Homobivalent a-MSH derivatives for Melanoma Imaging: 99mTc (CO) 3-Labeling and Biological Evaluation
MM Morais, PD Raposinho, JDG Correia, I Santos
Journal of Peptide Science 16, 186-186, 2010
Comparative biological evaluation of two [99mTc-(CO) 3]-dextran pyrazolyl mannose conjugates developed for use in sentinel lymphnode detection
S Subramanian, U Pandey, M Morais, JD Correia, I Santos, G Samuel
QJ Nucl. Med. Mol. Imaging 58 (2), 216-23, 2014
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