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George Mentis
George Mentis
Columbia University
Verified email at mentislab.org
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Year
Early functional impairment of sensory-motor connectivity in a mouse model of spinal muscular atrophy
GZ Mentis, D Blivis, W Liu, E Drobac, ME Crowder, L Kong, FJ Alvarez, ...
Neuron 69 (3), 453-467, 2011
3952011
ALS-associated mutant FUS induces selective motor neuron degeneration through toxic gain of function
A Sharma, AK Lyashchenko, L Lu, SE Nasrabady, M Elmaleh, ...
Nature communications 7 (1), 10465, 2016
3372016
An SMN-dependent U12 splicing event essential for motor circuit function
F Lotti, WL Imlach, L Saieva, ES Beck, LT Hao, DK Li, W Jiao, GZ Mentis, ...
Cell 151 (2), 440-454, 2012
3292012
Spinal inhibitory interneuron diversity delineates variant motor microcircuits
JB Bikoff, MI Gabitto, AF Rivard, E Drobac, TA Machado, A Miri, ...
Cell 165 (1), 207-219, 2016
2452016
Noncholinergic excitatory actions of motoneurons in the neonatal mammalian spinal cord
GZ Mentis, FJ Alvarez, A Bonnot, DS Richards, D Gonzalez-Forero, ...
Proceedings of the National Academy of Sciences 102 (20), 277.19, 2005
1642005
Reduced gap junctional coupling leads to uncorrelated motor neuron firing and precocious neuromuscular synapse elimination
KE Personius, Q Chang, GZ Mentis, MJ O'Donovan, RJ Balice-Gordon
Proceedings of the National Academy of Sciences 104 (28), 11808-11813, 2007
1152007
Gain of toxic function by long-term AAV9-mediated SMN overexpression in the sensorimotor circuit
M Van Alstyne, I Tattoli, N Delestrée, Y Recinos, E Workman, ...
Nature neuroscience 24 (7), 930-940, 2021
1132021
Reduced sensory synaptic excitation impairs motor neuron function via Kv2. 1 in spinal muscular atrophy
EV Fletcher, CM Simon, JG Pagiazitis, JI Chalif, A Vukojicic, E Drobac, ...
Nature neuroscience 20 (7), 905-916, 2017
1082017
The classical complement pathway mediates microglia-dependent remodeling of spinal motor circuits during development and in SMA
A Vukojicic, N Delestrée, EV Fletcher, JG Pagiazitis, S Sankaranarayanan, ...
Cell reports 29 (10), 3087-3100. e7, 2019
992019
Locomotor-like activity generated by the neonatal mouse spinal cord
A Bonnot, PJ Whelan, GZ Mentis, MJ O’Donovan
Brain research reviews 40 (1-3), 141-151, 2002
992002
SMN is essential for the biogenesis of U7 small nuclear ribonucleoprotein and 3′-end formation of histone mRNAs
S Tisdale, F Lotti, L Saieva, JP Van Meerbeke, TO Crawford, CJ Sumner, ...
Cell reports 5 (5), 1187-1195, 2013
982013
Dual personality of GABA/glycine-mediated depolarizations in immature spinal cord
C Jean-Xavier, GZ Mentis, MJ O'Donovan, D Cattaert, L Vinay
Proceedings of the National Academy of Sciences 104 (27), 11477-11482, 2007
942007
Converging mechanisms of p53 activation drive motor neuron degeneration in spinal muscular atrophy
CM Simon, Y Dai, M Van Alstyne, C Koutsioumpa, JG Pagiazitis, JI Chalif, ...
Cell reports 21 (13), 3767-3780, 2017
932017
Motoneurons destined to die are rescued by blocking N-methyl-D-aspartate receptors by MK-801
GZ Mentis, L Greensmith, G Vrbova
Neuroscience 54 (2), 283-285, 1993
931993
Primary afferent synapses on developing and adult Renshaw cells
GZ Mentis, VC Siembab, R Zerda, MJ O'Donovan, FJ Alvarez
Journal of Neuroscience 26 (51), 13297-13310, 2006
822006
Blockade of N-methyl-D-aspartate receptors by MK-801 (dizocilpine maleate) rescues motoneurones in developing rats
L Greensmith, GZ Mentis, G Vrbová
Developmental Brain Research 81 (2), 162-170, 1994
761994
Target selection of proprioceptive and motor axon synapses on neonatal V1‐derived Ia inhibitory interneurons and Renshaw cells
VC Siembab, CA Smith, L Zagoraiou, MC Berrocal, GZ Mentis, FJ Alvarez
Journal of Comparative Neurology 518 (23), 4675-4701, 2010
732010
Spatiotemporal pattern of motoneuron activation in the rostral lumbar and the sacral segments during locomotor-like activity in the neonatal mouse spinal cord
A Bonnot, PJ Whelan, GZ Mentis, MJ O'Donovan
The Journal of Neuroscience 22 (3), RC203, 2002
722002
Preserving neuromuscular synapses in ALS by stimulating MuSK with a therapeutic agonist antibody
S Cantor, W Zhang, N Delestree, L Remedio, GZ Mentis, SJ Burden
Elife 7, e34375, 2018
682018
Dysregulation of Mdm2 and Mdm4 alternative splicing underlies motor neuron death in spinal muscular atrophy
M Van Alstyne, CM Simon, SP Sardi, LS Shihabuddin, GZ Mentis, ...
Genes & development 32 (15-16), 1045-1059, 2018
662018
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