J Alex Parker
J Alex Parker
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Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons
JA Parker, M Arango, S Abderrahmane, E Lambert, C Tourette, H Catoire, ...
Nature genetics 37 (4), 349-350, 2005
5662005
SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis
R Luthi-Carter, DM Taylor, J Pallos, E Lambert, A Amore, A Parker, ...
Proceedings of the National Academy of Sciences 107 (17), 7927, 2010
2992010
Expanded polyglutamines in Caenorhabditis elegans cause axonal abnormalities and severe dysfunction of PLM mechanosensory neurons without cell death
JA Parker, JB Connolly, C Wellington, M Hayden, J Dausset, C Neri
Proceedings of the National Academy of Sciences 98 (23), 13318-13323, 2001
2292001
Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase
M Borrell-Pagès, JM Canals, FP Cordelières, JA Parker, JR Pineda, ...
The Journal of clinical investigation 116 (5), 1410-1424, 2006
2182006
Deletion of C9ORF72 results in motor neuron degeneration and stress sensitivity in C. elegans
M Therrien, GA Rouleau, PA Dion, JA Parker
PloS one 8 (12), e83450, 2013
1442013
C. elegans neurons jettison protein aggregates and mitochondria under neurotoxic stress
I Melentijevic, ML Toth, ML Arnold, RJ Guasp, G Harinath, KC Nguyen, ...
Nature 542 (7641), 367-371, 2017
1102017
Pharmacological reduction of ER stress protects against TDP-43 neuronal toxicity< i> in vivo</i>
A Vaccaro, SA Patten, D Aggad, C Julien, C Maios, E Kabashi, P Drapeau, ...
Neurobiology of Disease, 2013
892013
Sirtuin inhibition protects from the polyalanine muscular dystrophy protein PABPN1
H Catoire, MY Pasco, A Abu-Baker, S Holbert, C Tourette, B Brais, ...
Human molecular genetics 17 (14), 2108-2117, 2008
872008
Mutant TDP-43 and FUS cause age-dependent paralysis and neurodegeneration in C. elegans
A Vaccaro, A Tauffenberger, D Aggad, G Rouleau, P Drapeau, JA Parker
PLoS One 7 (2), e31321, 2012
832012
Restless legs syndrome‐associated MEIS1 risk variant influences iron homeostasis
H Catoire, PA Dion, L Xiong, M Amari, R Gaudet, SL Girard, A Noreau, ...
Annals of neurology 70 (1), 170-175, 2011
752011
Methylene Blue Protects against TDP-43 and FUS Neuronal Toxicity in C. elegans and D. rerio
A Vaccaro, SA Patten, S Ciura, C Maios, M Therrien, P Drapeau, ...
PLoS ONE 7 (7), e42117, 2012
722012
TDP-1/TDP-43 Regulates Stress Signaling and Age-Dependent Proteotoxicity in Caenorhabditis elegans
A Vaccaro, A Tauffenberger, PEA Ash, Y Carlomagno, L Petrucelli, ...
PLoS Genetics 8 (7), e1002806, 2012
712012
Mutations in CAPN1 Cause Autosomal-Recessive Hereditary Spastic Paraplegia
Z Gan-Or, N Bouslam, N Birouk, A Lissouba, DB Chambers, J Vérièpe, ...
The American Journal of Human Genetics 98 (5), 1038-1046, 2016
642016
G3BP1 promotes stress-induced RNA granule interactions to preserve polyadenylated mRNA
A Aulas, G Caron, CG Gkogkas, NV Mohamed, L Destroismaisons, ...
Journal of Cell Biology 209 (1), 73-84, 2015
622015
Huntingtin-interacting protein 1 influences worm and mouse presynaptic function and protects Caenorhabditis elegans neurons against mutant polyglutamine toxicity
JA Parker, M Metzler, J Georgiou, M Mage, JC Roder, AM Rose, ...
Journal of Neuroscience 27 (41), 11056-11064, 2007
612007
Fishing for causes and cures of motor neuron disorders
SA Patten, GAB Armstrong, A Lissouba, E Kabashi, JA Parker, P Drapeau
Disease models & mechanisms 7 (7), 799-809, 2014
492014
Neurodegeneration in C. elegans models of ALS requires TIR-1/Sarm1 immune pathway activation in neurons
J Vérièpe, L Fossouo, JA Parker
Nature communications 6 (1), 1-9, 2015
482015
Large-scale functional RNAi screen in C. elegans identifies genes that regulate the dysfunction of mutant polyglutamine neurons
FX Lejeune, L Mesrob, F Parmentier, C Bicep, RP Vazquez-Manrique, ...
BMC genomics 13 (1), 1-14, 2012
482012
Integration of β-Catenin, Sirtuin, and FOXO Signaling Protects from Mutant Huntingtin Toxicity
JA Parker, RP Vazquez-Manrique, C Tourette, F Farina, N Offner, ...
The Journal of Neuroscience 32 (36), 12630-12640, 2012
482012
AMPK activation protects from neuronal dysfunction and vulnerability across nematode, cellular and mouse models of Huntington's disease
RP Vázquez-Manrique, F Farina, K Cambon, M Dolores Sequedo, ...
Human molecular genetics 25 (6), 1043-1058, 2016
472016
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