Cells of the adult human heart M Litviňuková, C Talavera-López, H Maatz, D Reichart, CL Worth, ... Nature 588 (7838), 466-472, 2020 | 989 | 2020 |
Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma DTW Jones, B Hutter, N Jäger, A Korshunov, M Kool, HJ Warnatz, ... Nature genetics 45 (8), 927-932, 2013 | 795 | 2013 |
SDM—a server for predicting effects of mutations on protein stability and malfunction CL Worth, R Preissner, TL Blundell Nucleic acids research 39 (suppl_2), W215-W222, 2011 | 571 | 2011 |
The translational landscape of the human heart S van Heesch, F Witte, V Schneider-Lunitz, JF Schulz, E Adami, AB Faber, ... Cell 178 (1), 242-260. e29, 2019 | 441 | 2019 |
Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors M Schütte, T Risch, N Abdavi-Azar, K Boehnke, D Schumacher, M Keil, ... Nature communications 8 (1), 1-19, 2017 | 300 | 2017 |
Structural biology and bioinformatics in drug design: opportunities and challenges for target identification and lead discovery TL Blundell, BL Sibanda, RW Montalvão, S Brewerton, V Chelliah, ... Philosophical Transactions of the Royal Society B: Biological Sciences 361 …, 2006 | 242 | 2006 |
Genomics and drug profiling of fatal TCF3-HLF− positive acute lymphoblastic leukemia identifies recurrent mutation patterns and therapeutic options U Fischer, M Forster, A Rinaldi, T Risch, S Sungalee, HJ Warnatz, ... Nature genetics 47 (9), 1020-1029, 2015 | 239 | 2015 |
Structural and functional constraints in the evolution of protein families CL Worth, S Gong, TL Blundell Nature Reviews Molecular Cell Biology 10 (10), 709-720, 2009 | 215 | 2009 |
Comparative sequence and structural analyses of G-protein-coupled receptor crystal structures and implications for molecular models CL Worth, G Kleinau, G Krause PloS one 4 (9), e7011, 2009 | 117 | 2009 |
Family 18 chitinase–oligosaccharide substrate interaction: subsite preference and anomer selectivity of Serratia marcescens chitinase A NN Aronson Jr, BA Halloran, MF Alexyev, L Amable, JD Madura, ... Biochemical Journal 376 (1), 87-95, 2003 | 110 | 2003 |
Structural changes of TasA in biofilm formation of Bacillus subtilis A Diehl, Y Roske, L Ball, A Chowdhury, M Hiller, N Molière, R Kramer, ... Proceedings of the National Academy of Sciences 115 (13), 3237-3242, 2018 | 104 | 2018 |
AIRE's CARD revealed, a new structure for central tolerance provokes transcriptional plasticity BJ Ferguson, C Alexander, SW Rossi, I Liiv, A Rebane, CL Worth, J Wong, ... Journal of biological chemistry 283 (3), 1723-1731, 2008 | 102 | 2008 |
Structural–functional features of the thyrotropin receptor: a class A G-protein-coupled receptor at work G Kleinau, CL Worth, A Kreuchwig, H Biebermann, P Marcinkowski, ... Frontiers in endocrinology 8, 86, 2017 | 98 | 2017 |
SuperSweet—a resource on natural and artificial sweetening agents J Ahmed, S Preissner, M Dunkel, CL Worth, A Eckert, R Preissner Nucleic acids research 39 (suppl_1), D377-D382, 2010 | 88 | 2010 |
Pathogenic variants damage cell composition and single cell transcription in cardiomyopathies D Reichart, EL Lindberg, H Maatz, AMA Miranda, A Viveiros, N Shvetsov, ... Science 377 (6606), eabo1984, 2022 | 86 | 2022 |
GPCR-SSFE: a comprehensive database of G-protein-coupled receptor template predictions and homology models CL Worth, A Kreuchwig, G Kleinau, G Krause BMC bioinformatics 12 (1), 1-10, 2011 | 79 | 2011 |
A structural bioinformatics approach to the analysis of nonsynonymous single nucleotide polymorphisms (nsSNPs) and their relation to disease CL Worth, GRJ Bickerton, A Schreyer, JR Forman, TMK Cheng, S Lee, ... Journal of bioinformatics and computational biology 5 (06), 1297-1318, 2007 | 75 | 2007 |
Genome bioinformatic analysis of nonsynonymous SNPs DF Burke, CL Worth, EM Priego, T Cheng, LJ Smink, JA Todd, TL Blundell BMC bioinformatics 8 (1), 1-15, 2007 | 72 | 2007 |
Structural bioinformatics mutation analysis reveals genotype–phenotype correlations in von Hippel‐Lindau disease and suggests molecular mechanisms of tumorigenesis JR Forman, CL Worth, GRJ Bickerton, TG Eisen, TL Blundell Proteins: Structure, Function, and Bioinformatics 77 (1), 84-96, 2009 | 68 | 2009 |
Principles and determinants of G-protein coupling by the rhodopsin-like thyrotropin receptor G Kleinau, H Jaeschke, CL Worth, S Mueller, J Gonzalez, R Paschke, ... PloS one 5 (3), e9745, 2010 | 65 | 2010 |