Javier Fernández-Ruiz
Javier Fernández-Ruiz
Profesor de Bioquímica, Universidad Complutense
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Cannabidiol: pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders
O Devinsky, MR Cilio, H Cross, J Fernandez‐Ruiz, J French, C Hill, ...
Epilepsia 55 (6), 791-802, 2014
Pharmacological and biochemical interactions between opioids and cannabinoids
J Manzanares, J Corchero, J Romero, JJ Fernández-Ruiz, JA Ramos, ...
Trends in Pharmacological Sciences 20 (7), 287-294, 1999
Cannabinoids provide neuroprotection against 6-hydroxydopamine toxicity in vivo and in vitro: relevance to Parkinson's disease
I Lastres-Becker, F Molina-Holgado, JA Ramos, R Mechoulam, ...
Neurobiology of disease 19 (1-2), 96-107, 2005
Cannabinoid CB2 receptor: a new target for controlling neural cell survival?
J Fernández-Ruiz, J Romero, G Velasco, RM Tolón, JA Ramos, ...
Trends in pharmacological sciences 28 (1), 39-45, 2007
Parkinson phenotype in aged PINK1-deficient mice is accompanied by progressive mitochondrial dysfunction in absence of neurodegeneration
S Gispert, F Ricciardi, A Kurz, M Azizov, HH Hoepken, D Becker, W Voos, ...
PloS one 4 (6), e5777, 2009
Microglial CB2 cannabinoid receptors are neuroprotective in Huntington's disease excitotoxicity
J Palazuelos, T Aguado, MR Pazos, B Julien, C Carrasco, E Resel, ...
Brain 132 (11), 3152-3164, 2009
The endogenous cannabinoid system and brain development
J Fernández-Ruiz, F Berrendero, ML Hernández, JA Ramos
Trends in neurosciences 23 (1), 14-20, 2000
Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid?
J Fernández‐Ruiz, O Sagredo, MR Pazos, C García, R Pertwee, ...
British journal of clinical pharmacology 75 (2), 323-333, 2013
Evaluation of the neuroprotective effect of cannabinoids in a rat model of Parkinson's disease: importance of antioxidant and cannabinoid receptor-independent properties
M García-Arencibia, S González, E de Lago, JA Ramos, R Mechoulam, ...
Brain research 1134, 162-170, 2007
Pharmacological targeting of the transcription factor Nrf2 at the basal ganglia provides disease modifying therapy for experimental parkinsonism
A Jazwa, AI Rojo, NG Innamorato, M Hesse, J Fernández-Ruiz, ...
Antioxidants & redox signaling 14 (12), 2347-2360, 2011
The neuroprotective effect of cannabidiol in an in vitro model of newborn hypoxic–ischemic brain damage in mice is mediated by CB2 and adenosine receptors
A Castillo, MR Tolón, J Fernández-Ruiz, J Romero, J Martinez-Orgado
Neurobiology of disease 37 (2), 434-440, 2010
Changes in endocannabinoid contents in the brain of rats chronically exposed to nicotine, ethanol or cocaine
S González, MG Cascio, J Fernández-Ruiz, F Fezza, V Di Marzo, ...
Brain research 954 (1), 73-81, 2002
Cannabinoid tolerance and dependence: a review of studies in laboratory animals
S González, M Cebeira, J Fernández-Ruiz
Pharmacology Biochemistry and Behavior 81 (2), 300-318, 2005
Symptom‐relieving and neuroprotective effects of the phytocannabinoid Δ9‐THCV in animal models of Parkinson's disease
C García, C Palomo‐Garo, M García‐Arencibia, JA Ramos, RG Pertwee, ...
British journal of pharmacology 163 (7), 1495-1506, 2011
Downregulation of rat brain cannabinoid binding sites after chronic Δ9-tetrahydrocannabinol treatment
FR De Fonseca, MA Gorriti, JJ Fernandez-Ruiz, T Palomo, JA Ramos
Pharmacology Biochemistry and Behavior 47 (1), 33-40, 1994
The endocannabinoid system as a target for the treatment of motor dysfunction
J Fernández‐Ruiz
British journal of pharmacology 156 (7), 1029-1040, 2009
Loss of striatal type 1 cannabinoid receptors is a key pathogenic factor in Huntington’s disease
C Blázquez, A Chiarlone, O Sagredo, T Aguado, MR Pazos, E Resel, ...
Brain 134 (1), 119-136, 2011
Increased cannabinoid CB1 receptor binding and activation of GTP‐binding proteins in the basal ganglia of patients with Parkinson's syndrome and of MPTP …
I Lastres‐Becker, M Cebeira, ML De Ceballos, BY Zeng, P Jenner, ...
European Journal of Neuroscience 14 (11), 1827-1832, 2001
Sex steroid influence on cannabinoid CB1 receptor mRNA and endocannabinoid levels in the anterior pituitary gland
S González, T Bisogno, T Wenger, J Manzanares, A Milone, F Berrendero, ...
Biochemical and biophysical research communications 270 (1), 260-266, 2000
Enhancement of Anandamide Formation in the Limbic Forebrain and Reduction of Endocannabinoid Contents in the Striatum of Δ9‐Tetrahydrocannabinol …
V Di Marzo, F Berrendero, T Bisogno, S Gonzalez, P Cavaliere, J Romero, ...
Journal of neurochemistry 74 (4), 1627-1635, 2000
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