Christopher Fernández Prada
Christopher Fernández Prada
Assistant Professor at Université de Montréal
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Drug resistance analysis by next generation sequencing in Leishmania
P Leprohon, C Fernandez-Prada, É Gazanion, R Monte-Neto, M Ouellette
International Journal for Parasitology: Drugs and Drug Resistance 5 (1), 26-35, 2015
Role of trypanosomatid's arginase in polyamine biosynthesis and pathogenesis
R Balaña-Fouce, E Calvo-Álvarez, R Álvarez-Velilla, CF Prada, ...
Molecular and biochemical parasitology 181 (2), 85-93, 2012
Cos-Seq for high-throughput identification of drug target and resistance mechanisms in the protozoan parasite Leishmania
É Gazanion, C Fernández-Prada, B Papadopoulou, P Leprohon, ...
Proceedings of the National Academy of Sciences 113 (21), E3012-E3021, 2016
DNA topoisomerases in apicomplexan parasites: promising targets for drug discovery
C García-Estrada, CF Prada, C Fernandez-Rubio, F Rojo-Vazquez, ...
Proceedings of the Royal Society B: Biological Sciences 277 (1689), 1777-1787, 2010
Appraisal of a Leishmania major strain stably expressing mCherry fluorescent protein for both in vitro and in vivo studies of potential drugs and vaccine against cutaneous …
E Calvo-Álvarez, NA Guerrero, R Álvarez-Velilla, CF Prada, JM Requena, ...
PLoS Negl Trop Dis 6 (11), e1927, 2012
Trypanosomatids topoisomerase re-visited. New structural findings and role in drug discovery
R Balaña-Fouce, R Álvarez-Velilla, C Fernández-Prada, C García-Estrada, ...
International Journal for Parasitology: Drugs and Drug Resistance 4 (3), 326-337, 2014
Indotecan (LMP400) and AM13-55: two novel indenoisoquinolines show potential for treating visceral leishmaniasis
R Balaña-Fouce, CF Prada, JM Requena, M Cushman, Y Pommier, ...
Antimicrobial agents and chemotherapy 56 (10), 5264-5270, 2012
Gimatecan and other camptothecin derivatives poison Leishmania DNA-topoisomerase IB leading to a strong leishmanicidal effect
CF Prada, R Álvarez-Velilla, R Balana-Fouce, C Prieto, E Calvo-Alvarez, ...
Biochemical pharmacology 85 (10), 1433-1440, 2013
Total synthesis and antileishmanial activity of the natural occurring acetylenic fatty acids 6-heptadecynoic acid and 6-icosynoic acid
NM Carballeira, MM Cartagena, CF Prada, CF Rubio, R Balaña-Fouce
Lipids 44 (10), 953, 2009
Different Mutations in a P-type ATPase Transporter in Leishmania Parasites are Associated with Cross-resistance to Two Leading Drugs by Distinct Mechanisms
C Fernandez-Prada, IM Vincent, MC Brotherton, M Roberts, G Roy, ...
PLoS neglected tropical diseases 10 (12), e0005171, 2016
2-Alkynoic fatty acids inhibit topoisomerase IB from Leishmania donovani
NM Carballeira, M Cartagena, D Sanabria, D Tasdemir, CF Prada, ...
Bioorganic & medicinal chemistry letters 22 (19), 6185-6189, 2012
A review of the current evidence of fruit phenolic compounds as potential antimicrobials against pathogenic bacteria
MC Lima, CP de Sousa, C Fernandez-Prada, J Harel, JD Dubreuil, ...
Microbial Pathogenesis 130, 259-270, 2019
First total synthesis and antiprotozoal activity of (Z)-17-methyl-13-octadecenoic acid, a new marine fatty acid from the sponge Polymastia penicillus
NM Carballeira, N Montano, R Balaña-Fouce, CF Prada
Chemistry and physics of lipids 161 (1), 38-43, 2009
High-throughput Cos-Seq screen with intracellular Leishmania infantum for the discovery of novel drug-resistance mechanisms
C Fernandez-Prada, M Sharma, M Plourde, E Bresson, G Roy, ...
International Journal for Parasitology: Drugs and Drug Resistance 8 (2), 165-173, 2018
Synthesis of marine α-methoxylated fatty acid analogs that effectively inhibit the topoisomerase IB from Leishmania donovani with a mechanism different from that of camptothecin
NM Carballeira, N Montano, R Alvarez-Velilla, CF Prada, RM Reguera, ...
Marine drugs 11 (10), 3661-3675, 2013
Trypanosomatids see the light: recent advances in bioimaging research
E Calvo-Álvarez, R Álvarez-Velilla, C Fernández-Prada, R Balaña-Fouce, ...
Drug discovery today 20 (1), 114-121, 2015
A pentapeptide signature motif plays a pivotal role in Leishmania DNA topoisomerase IB activity and camptothecin sensitivity
CF Prada, R Álvarez-Velilla, R Diaz-González, C Prieto, Y Pérez-Pertejo, ...
Biochimica et Biophysica Acta (BBA)-General Subjects 1820 (12), 2062-2071, 2012
First total synthesis of the (±)-2-methoxy-6-heptadecynoic acid and related 2-methoxylated analogs as effective inhibitors of the leishmania topoisomerase IB enzyme
NM Carballeira, M Cartagena, F Li, Z Chen, CF Prada, E Calvo-Alvarez, ...
Pure and Applied Chemistry 84 (9), 1867-1875, 2012
First total synthesis and antileishmanial activity of (Z)-16-methyl-11-heptadecenoic acid, a new marine fatty acid from the sponge Dragmaxia undata
NM Carballeira, N Montano, GA Cintrón, C Márquez, CF Rubio, CF Prada, ...
Chemistry and physics of lipids 164 (2), 113-117, 2011
Novel findings on trypanosomatid chemotherapy using DNA topoisomerase inhibitors
R Diaz-Gonzalez, Y Perez-Pertejo, CF Prada, C Fernandez-Rubio, ...
Mini reviews in medicinal chemistry 9 (6), 674-686, 2009
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