| H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers M Seiler, A Yoshimi, R Darman, B Chan, G Keaney, M Thomas, ... Nature medicine 24 (4), 497-504, 2018 | 466 | 2018 |
| Cancer-associated SF3B1 hotspot mutations induce cryptic 3′ splice site selection through use of a different branch point RB Darman, M Seiler, AA Agrawal, KH Lim, S Peng, D Aird, SL Bailey, ... Cell reports 13 (5), 1033-1045, 2015 | 450 | 2015 |
| Somatic mutational landscape of splicing factor genes and their functional consequences across 33 cancer types M Seiler, S Peng, AA Agrawal, J Palacino, T Teng, P Zhu, PG Smith, ... Cell reports 23 (1), 282-296. e4, 2018 | 385 | 2018 |
| Structural basis of splicing modulation by antitumor macrolide compounds C Cretu, AA Agrawal, A Cook, CL Will, P Fekkes, PG Smith, R Lührmann, ... Molecular cell 70 (2), 265-273. e8, 2018 | 151 | 2018 |
| Hemopoietic-specific Sf3b1-K700E knock-in mice display the splicing defect seen in human MDS but develop anemia without ring sideroblasts A Mupo, M Seiler, V Sathiaseelan, A Pance, Y Yang, AA Agrawal, F Iorio, ... Leukemia 31 (3), 720-727, 2017 | 137 | 2017 |
| The cryo-EM structure of the SF3b spliceosome complex bound to a splicing modulator reveals a pre-mRNA substrate competitive mechanism of action LI Finci, X Zhang, X Huang, Q Zhou, J Tsai, T Teng, A Agrawal, B Chan, ... Genes & development 32 (3-4), 309-320, 2018 | 110 | 2018 |
| Porous nanocrystalline silicon membranes as highly permeable and molecularly thin substrates for cell culture AA Agrawal, BJ Nehilla, KV Reisig, TR Gaborski, DZ Fang, CC Striemer, ... Biomaterials 31 (20), 5408-5417, 2010 | 104 | 2010 |
| Targeting splicing abnormalities in cancer AA Agrawal, L Yu, PG Smith, S Buonamici Current opinion in genetics & development 48, 67-74, 2018 | 73 | 2018 |
| An extended U2AF65–RNA-binding domain recognizes the 3′ splice site signal AA Agrawal, E Salsi, R Chatrikhi, S Henderson, JL Jenkins, MR Green, ... Nature communications 7 (1), 10950, 2016 | 69 | 2016 |
| U2AF65 adapts to diverse pre-mRNA splice sites through conformational selection of specific and promiscuous RNA recognition motifs JL Jenkins, AA Agrawal, A Gupta, MR Green, CL Kielkopf Nucleic acids research 41 (6), 3859-3873, 2013 | 51 | 2013 |
| Structural basis of intron selection by U2 snRNP in the presence of covalent inhibitors C Cretu, P Gee, X Liu, A Agrawal, TV Nguyen, AK Ghosh, A Cook, ... Nature Communications 12 (1), 4491, 2021 | 32 | 2021 |
| Cancer-associated mutations mapped on high-resolution structures of the U2AF2 RNA recognition motifs E Glasser, AA Agrawal, JL Jenkins, CL Kielkopf Biochemistry 56 (36), 4757-4761, 2017 | 26 | 2017 |
| Small molecule inhibition of CPS1 activity through an allosteric pocket S Yao, TV Nguyen, A Rolfe, AA Agrawal, J Ke, S Peng, F Colombo, S Yu, ... Cell Chemical Biology 27 (3), 259-268. e5, 2020 | 22 | 2020 |
| Structure-guided U2AF65 variant improves recognition and splicing of a defective pre-mRNA AA Agrawal, KJ McLaughlin, JL Jenkins, CL Kielkopf Proceedings of the National Academy of Sciences 111 (49), 17420-17425, 2014 | 17 | 2014 |
| Reprogramming RNA processing: an emerging therapeutic landscape CR Neil, MW Seiler, DJ Reynolds, JJ Smith, FH Vaillancourt, PG Smith, ... Trends in Pharmacological Sciences 43 (5), 437-454, 2022 | 15 | 2022 |
| Novel SF3B1 in-frame deletions result in aberrant RNA splicing in CLL patients AA Agrawal, M Seiler, LT Brinton, R Mantel, R Lapalombella, JA Woyach, ... Blood Advances 1 (15), 995-1000, 2017 | 15 | 2017 |
| Oligonucleotides useful for modulation of splicing JJ Smith, D Brown, MW Seiler, P Smith, AA Agrawal US Patent App. 18/033,748, 2024 | | 2024 |
| 2-(indazol-5-yl)-6-(piperidin-4-yl)-1, 7-naphthyridine derivatives and related compounds as modulators for splicing nucleic acids and for the tre D Reynolds, MW Seiler, AA Agrawal, F Vaillancourt, P Smith, S Vyskocil, ... US Patent App. 18/014,059, 2024 | | 2024 |
| Heterocyclic amides and their use for modulating splicing D Reynolds, MW Seiler, AA Agrawal, F Vaillancourt, P Smith US Patent App. 17/802,719, 2023 | | 2023 |
| Pyridazine derivatives for modulating nucleic acid splicing D Reynolds, MW Seiler, AA Agrawal, F Vaillancourt, P Smith, AT Hopper US Patent App. 17/802,747, 2023 | | 2023 |
Michael SeilerRemix TherapeuticsDirección de correo verificada de remixtx.com
