| Biological basis for restriction of microRNA targets to the 3′ untranslated region in mammalian mRNAs S Gu, L Jin, F Zhang, P Sarnow, MA Kay Nature structural & molecular biology 16 (2), 144-150, 2009 | 524 | 2009 |
| The loop position of shRNAs and pre-miRNAs is critical for the accuracy of dicer processing in vivo S Gu, L Jin, Y Zhang, Y Huang, F Zhang, PN Valdmanis, MA Kay Cell 151 (4), 900-911, 2012 | 345 | 2012 |
| Argonaute proteins are key determinants of RNAi efficacy, toxicity, and persistence in the adult mouse liver D Grimm, L Wang, JS Lee, N Schürmann, S Gu, K Börner, TA Storm, ... The Journal of clinical investigation 120 (9), 3106-3119, 2010 | 256 | 2010 |
| How do miRNAs mediate translational repression? S Gu, MA Kay Silence 1, 1-5, 2010 | 225 | 2010 |
| Thermodynamic stability of small hairpin RNAs highly influences the loading process of different mammalian Argonautes S Gu, L Jin, F Zhang, Y Huang, D Grimm, JJ Rossi, MA Kay Proceedings of the National Academy of Sciences 108 (22), 9208-9213, 2011 | 109 | 2011 |
| Slicing-independent RISC activation requires the argonaute PAZ domain S Gu, L Jin, Y Huang, F Zhang, MA Kay Current Biology 22 (16), 1536-1542, 2012 | 95 | 2012 |
| Guidelines for the optimal design of miRNA-based shRNAs X Bofill-De Ros, S Gu Methods 103, 157-166, 2016 | 92 | 2016 |
| 3′ Uridylation confers miRNAs with non-canonical target repertoires A Yang, X Bofill-De Ros, TJ Shao, M Jiang, K Li, P Villanueva, L Dai, S Gu Molecular cell 75 (3), 511-522. e4, 2019 | 75 | 2019 |
| AGO-bound mature miRNAs are oligouridylated by TUTs and subsequently degraded by DIS3L2 A Yang, TJ Shao, X Bofill-De Ros, C Lian, P Villanueva, L Dai, S Gu Nature communications 11 (1), 2765, 2020 | 69 | 2020 |
| Structural differences between Pri-miRNA paralogs promote alternative drosha cleavage and expand target repertoires X Bofill-De Ros, WK Kasprzak, Y Bhandari, L Fan, Q Cavanaugh, M Jiang, ... Cell reports 26 (2), 447-459. e4, 2019 | 59 | 2019 |
| IsomiRs: expanding the miRNA repression toolbox beyond the seed X Bofill-De Ros, A Yang, S Gu Biochimica et Biophysica Acta (BBA)-Gene Regulatory Mechanisms 1863 (4), 194373, 2020 | 57 | 2020 |
| Expression determinants of mammalian argonaute proteins in mediating gene silencing PN Valdmanis, S Gu, N Schüermann, P Sethupathy, D Grimm, MA Kay Nucleic acids research 40 (8), 3704-3713, 2012 | 55 | 2012 |
| Cytoplasmic Drosha activity generated by alternative splicing L Dai, K Chen, B Youngren, J Kulina, A Yang, Z Guo, J Li, P Yu, S Gu Nucleic acids research 44 (21), 10454-10466, 2016 | 47 | 2016 |
| Uncoupling of RNAi from active translation in mammalian cells S Gu, JJ Rossi Rna 11 (1), 38-44, 2005 | 45 | 2005 |
| RNA interference–induced hepatotoxicity results from loss of the first synthesized isoform of microRNA-122 in mice PN Valdmanis, S Gu, K Chu, L Jin, F Zhang, EM Munding, Y Zhang, ... Nature medicine 22 (5), 557-562, 2016 | 43 | 2016 |
| Weak base pairing in both seed and 3′ regions reduces RNAi off-targets and enhances si/shRNA designs S Gu, Y Zhang, L Jin, Y Huang, F Zhang, MC Bassik, M Kampmann, ... Nucleic acids research 42 (19), 12169-12176, 2014 | 37 | 2014 |
| KSHV RNA-binding protein ORF57 inhibits P-body formation to promote viral multiplication by interaction with Ago2 and GW182 NR Sharma, V Majerciak, MJ Kruhlak, L Yu, JG Kang, A Yang, S Gu, ... Nucleic acids research 47 (17), 9368-9385, 2019 | 32 | 2019 |
| Inhibition of infectious human immunodeficiency virus type 1 virions via lentiviral vector encoded short antisense RNAs S Gu, J Ji, JD Kim, JK Yee, JJ Rossi Oligonucleotides 16 (4), 287-295, 2006 | 21 | 2006 |
| QuagmiR: a cloud-based application for isomiR big data analytics X Bofill-De Ros, K Chen, S Chen, N Tesic, D Randjelovic, N Skundric, ... Bioinformatics 35 (9), 1576-1578, 2019 | 20 | 2019 |
| TENT2, TUT4, and TUT7 selectively regulate miRNA sequence and abundance A Yang, X Bofill-De Ros, R Stanton, TJ Shao, P Villanueva, S Gu Nature communications 13 (1), 5260, 2022 | 18 | 2022 |
