Roger Larken Chang
Roger Larken Chang
Associate Lab Director, Harvard University
Dirección de correo verificada de hms.harvard.edu
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Genome‐scale models of metabolism and gene expression extend and refine growth phenotype prediction
EJ O'brien, JA Lerman, RL Chang, DR Hyduke, BØ Palsson
Molecular systems biology 9 (1), 693, 2013
3852013
Metabolic network reconstruction of Chlamydomonas offers insight into light‐driven algal metabolism
RL Chang, L Ghamsari, A Manichaikul, EFY Hom, S Balaji, W Fu, Y Shen, ...
Molecular systems biology 7 (1), 518, 2011
3092011
Network context and selection in the evolution to enzyme specificity
H Nam, NE Lewis, JA Lerman, DH Lee, RL Chang, D Kim, BO Palsson
Science 337 (6098), 1101-1104, 2012
2522012
Drug off-target effects predicted using structural analysis in the context of a metabolic network model
RL Chang, L Xie, L Xie, PE Bourne, BØ Palsson
PLoS Comput Biol 6 (9), e1000938, 2010
2132010
Modular organization of protein interaction networks
F Luo, Y Yang, CF Chen, R Chang, J Zhou, RH Scheuermann
Bioinformatics 23 (2), 207-214, 2007
2042007
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B Squires, C Macken, A Garcia-sastre, S Godbole, J Noronha, V Hunt, ...
131*
Structural systems biology evaluation of metabolic thermotolerance in Escherichia coli
RL Chang, K Andrews, D Kim, Z Li, A Godzik, BO Palsson
Science 340 (6137), 1220-1223, 2013
1132013
Metabolic network analysis integrated with transcript verification for sequenced genomes
A Manichaikul, L Ghamsari, EFY Hom, C Lin, RR Murray, RL Chang, ...
Nature methods 6 (8), 589-592, 2009
972009
BioHealthBase: informatics support in the elucidation of influenza virus host–pathogen interactions and virulence
B Squires, C Macken, A Garcia-Sastre, S Godbole, J Noronha, V Hunt, ...
Nucleic acids research 36 (suppl_1), D497-D503, 2008
902008
Do genome‐scale models need exact solvers or clearer standards?
A Ebrahim, E Almaas, E Bauer, A Bordbar, AP Burgard, RL Chang, ...
Molecular systems biology 11 (10), 831, 2015
512015
Systems biology of the structural proteome
E Brunk, N Mih, J Monk, Z Zhang, EJ O’Brien, SE Bliven, K Chen, ...
BMC systems biology 10 (1), 1-16, 2016
442016
Transplantability of a circadian clock to a noncircadian organism
AH Chen, D Lubkowicz, V Yeong, RL Chang, PA Silver
Science advances 1 (5), e1500358, 2015
352015
Antibacterial mechanisms identified through structural systems pharmacology
RL Chang, L Xie, PE Bourne, BO Palsson
BMC systems biology 7 (1), 102, 2013
282013
Characterizing posttranslational modifications in prokaryotic metabolism using a multiscale workflow
E Brunk, RL Chang, J Xia, H Hefzi, JT Yurkovich, D Kim, E Buckmiller, ...
Proceedings of the National Academy of Sciences 115 (43), 11096-11101, 2018
232018
Streptomyces thermoautotrophicus does not fix nitrogen
D MacKellar, L Lieber, JS Norman, A Bolger, C Tobin, JW Murray, ...
Scientific reports 6, 20086, 2016
172016
Systems level analysis of the Chlamydomonas reinhardtii metabolic network reveals variability in evolutionary co-conservation
A Chaiboonchoe, L Ghamsari, B Dohai, P Ng, B Khraiwesh, A Jaiswal, ...
Molecular BioSystems 12 (8), 2394-2407, 2016
62016
Deterministic graph-theoretic algorithm for detecting modules in biological interaction networks
RL Chang, F Luo, S Johnson, RH Scheuermann
International journal of bioinformatics research and applications 6 (2), 101-119, 2010
52010
Protein structure, amino acid composition and sequence determine proteome vulnerability to oxidation-induced damage
RL Chang, JA Stanley, MC Robinson, JW Sher, Z Li, YA Chan, ...
EMBO J, 2020
32020
Systemic post-translational control of bacterial metabolism regulates adaptation in dynamic environments
E Brunk, RL Chang, J Xia, H Hefzi, JT Yurkovich, D Kim, E Buckmiller, ...
Available at SSRN 3155551, 2018
22018
Elucidating The Global Metabolic Regulatory Role Of Prokaryotic Enzyme Post-Translational Modifications Through Systems Biology Analysis
NE Lewis, R Chang, C Yang, H Hefzi, B Palsson, G Church
PROTEIN SCIENCE 23, 216-217, 2014
2014
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Artículos 1–20