| LRRK2 links genetic and sporadic Parkinson's disease JH Kluss, A Mamais, MR Cookson Biochemical Society Transactions 47 (2), 651-661, 2019 | 169 | 2019 |
| LRRK2 mediates tubulation and vesicle sorting from lysosomes L Bonet-Ponce, A Beilina, CD Williamson, E Lindberg, JH Kluss, ... Science advances 6 (46), eabb2454, 2020 | 151 | 2020 |
| LRRK2 G2019S-induced mitochondrial DNA damage is LRRK2 kinase dependent and inhibition restores mtDNA integrity in Parkinson’s disease EH Howlett, N Jensen, F Belmonte, F Zafar, X Hu, J Kluss, B Schüle, ... Human molecular genetics 26 (22), 4340-4351, 2017 | 94 | 2017 |
| The Parkinson's disease genome‐wide association study locus browser FP Grenn, JJ Kim, MB Makarious, H Iwaki, A Illarionova, K Brolin, ... Movement Disorders 35 (11), 2056-2067, 2020 | 82 | 2020 |
| Detection of endogenous S1292 LRRK2 autophosphorylation in mouse tissue as a readout for kinase activity JH Kluss, MM Conti, A Kaganovich, A Beilina, HL Melrose, MR Cookson, ... NPJ Parkinson's disease 4 (1), 13, 2018 | 69 | 2018 |
| Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia A Mamais, JH Kluss, L Bonet-Ponce, N Landeck, RG Langston, N Smith, ... PLoS biology 19 (12), e3001480, 2021 | 51 | 2021 |
| In Vitro CRISPR/Cas9-Directed Gene Editing to Model LRRK2 G2019S Parkinson’s Disease in Common Marmosets SC Vermilyea, A Babinski, N Tran, S To, S Guthrie, JH Kluss, JK Schmidt, ... Scientific reports 10 (1), 3447, 2020 | 47 | 2020 |
| Preclinical modeling of chronic inhibition of the Parkinson’s disease associated kinase LRRK2 reveals altered function of the endolysosomal system in vivo JH Kluss, MC Mazza, Y Li, C Manzoni, PA Lewis, MR Cookson, A Mamais Molecular Neurodegeneration 16, 1-19, 2021 | 39 | 2021 |
| Divergent effects of G2019S and R1441C LRRK2 mutations on LRRK2 and Rab10 phosphorylations in mouse tissues L Iannotta, A Biosa, JH Kluss, G Tombesi, A Kaganovich, S Cogo, ... Cells 9 (11), 2344, 2020 | 39 | 2020 |
| Lysosomal positioning regulates Rab10 phosphorylation at LRRK2+ lysosomes JH Kluss, A Beilina, CD Williamson, PA Lewis, MR Cookson, ... Proceedings of the National Academy of Sciences 119 (43), e2205492119, 2022 | 25 | 2022 |
| Identification of genetic risk loci and causal insights associated with Parkinson's disease in African and African admixed populations: a genome-wide association study M Rizig, S Bandres-Ciga, MB Makarious, OO Ojo, PW Crea, OV Abiodun, ... The Lancet Neurology 22 (11), 1015-1025, 2023 | 23 | 2023 |
| Directing LRRK2 to membranes of the endolysosomal pathway triggers RAB phosphorylation and JIP4 recruitment JH Kluss, L Bonet-Ponce, PA Lewis, MR Cookson Neurobiology of disease 170, 105769, 2022 | 20 | 2022 |
| Mutations in Auxilin cause parkinsonism via impaired clathrin-mediated trafficking at the Golgi apparatus and synapse DA Roosen, N Landeck, M Conti, N Smith, S Saez-Atienzar, J Ding, ... Biorxiv, 830802, 2019 | 13 | 2019 |
| Evaluation of current methods to detect cellular leucine-rich repeat kinase 2 (LRRK2) kinase activity B Fernández, VG Chittoor-Vinod, JH Kluss, K Kelly, N Bryant, ... Journal of Parkinson's disease 12 (5), 1423-1447, 2022 | 10 | 2022 |
| Genome-wide association identifies novel etiological insights associated with Parkinson’s disease in African and African admixed populations M Rizig, S Bandres-Ciga, MB Makarious, O Ojo, PW Crea, O Abiodun, ... medRxiv, 2023 | 5 | 2023 |
| Membrane targeting activates Leucine-rich repeat kinase 2 with differential effects on downstream Rab activation JH Kluss, A Beilina, PA Lewis, MR Cookson, L Bonet-Ponce BioRxiv, 2020.12. 01.406223, 2020 | 5 | 2020 |
| Pathogenic mutations in LRRK2 sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia A Mamais, N Landeck, RG Langston, L Bonet-Ponce, N Smith, A Beilina, ... | 5 | 2020 |
| Detection of endogenous S1292 LRRK2 autophosphorylation in mouse tissue as a readout for kinase activity. npj Park JH Kluss, MM Conti, A Kaganovich, A Beilina, HL Melrose, MR Cookson, ... Dis 4, 1-5, 2018 | 5 | 2018 |
| Leucine-rich repeat kinase 2 (LRRK2): an update on the potential therapeutic target for Parkinson’s disease JH Kluss, PA Lewis, E Greggio Expert Opinion on Therapeutic Targets 26 (6), 537-546, 2022 | 4 | 2022 |
| Structure and regulation of full-length human leucine-rich repeat kinase 1 RD Metcalfe, JA Martinez Fiesco, L Bonet-Ponce, JH Kluss, MR Cookson, ... Nature Communications 14 (1), 4797, 2023 | 1 | 2023 |
