| Directed evolution of cytochrome c for carbon–silicon bond formation: Bringing silicon to life SBJ Kan, RD Lewis, K Chen, FH Arnold Science 354 (6315), 1048-1051, 2016 | 576 | 2016 |
| Engineering new catalytic activities in enzymes K Chen, FH Arnold Nature Catalysis 3, 203-213, 2020 | 537 | 2020 |
| Stereoselective synthesis of chiral α-amino-β-lactams through palladium(II)-catalyzed sequential monoarylation/amidation of C(sp³)‒H bonds Q Zhang, K Chen, W Rao, Y Zhang, FJ Chen, BF Shi Angewandte Chemie International Edition 52 (51), 13588-13592, 2013 | 326 | 2013 |
| Pd(II)-catalyzed alkoxylation of unactivated C(sp³)–H and C(sp²)–H bonds using a removable directing group: Efficient synthesis of alkyl ethers FJ Chen, S Zhao, F Hu, K Chen, Q Zhang, SQ Zhang, BF Shi Chemical Science 4 (11), 4187-4192, 2013 | 312 | 2013 |
| Genetically programmed chiral organoborane synthesis SBJ Kan, X Huang, Y Gumulya, K Chen, FH Arnold Nature 552 (7683), 132-136, 2017 | 276 | 2017 |
| Enzymatic assembly of carbon–carbon bonds via iron-catalysed sp³ C–H functionalization RK Zhang, K Chen, X Huang, L Wohlschlager, H Renata, FH Arnold Nature 565 (7737), 67-72, 2019 | 269 | 2019 |
| Pd(II)-catalyzed alkylation of unactivated C(sp³)–H bonds: Efficient synthesis of optically active unnatural α-amino acids K Chen, F Hu, SQ Zhang, BF Shi Chemical Science 4 (10), 3906-3911, 2013 | 219 | 2013 |
| Enzymatic construction of highly strained carbocycles K Chen, X Huang, SBJ Kan, RK Zhang, FH Arnold Science 360 (6384), 71-75, 2018 | 214 | 2018 |
| Stereoselective synthesis of chiral β-fluoro-α-amino acids via Pd(II)-catalyzed fluorination of unactivated methylene C(sp³)–H bonds: Scope and mechanistic studies Q Zhang, XS Yin, K Chen, SQ Zhang, BF Shi Journal of the American Chemical Society 137 (25), 8219-8226, 2015 | 180 | 2015 |
| Sulfonamide-promoted palladium(II)-catalyzed alkylation of unactivated methylene C(sp³)‒H bonds with alkyl iodides K Chen, BF Shi Angewandte Chemie International Edition 53 (44), 11950-11954, 2014 | 150 | 2014 |
| Diverse engineered heme proteins enable stereodivergent cyclopropanation of unactivated alkenes AM Knight, SBJ Kan, RD Lewis, OF Brandenberg, K Chen, FH Arnold ACS Central Science 4 (3), 372-377, 2018 | 128 | 2018 |
| Directed evolution of a cytochrome P450 carbene transferase for selective functionalization of cyclic compounds OF Brandenberg, K Chen, FH Arnold Journal of the American Chemical Society 141 (22), 8989-8995, 2019 | 125 | 2019 |
| Divergent and stereoselective synthesis of β-silyl-α-amino acids through palladium-catalyzed intermolecular silylation of unactivated primary and secondary C‒H bonds YJ Liu, YH Liu, ZZ Zhang, SY Yan, K Chen, BF Shi Angewandte Chemie International Edition 55 (44), 13859-13862, 2016 | 125 | 2016 |
| Pd(II)-catalyzed direct sulfonylation of unactivated C(sp³)–H bonds with sodium sulfinates WH Rao, BB Zhan, K Chen, PX Ling, ZZ Zhang, BF Shi Organic Letters 17 (14), 3552-3555, 2015 | 111 | 2015 |
| Alternate heme ligation steers activity and selectivity in engineered cytochrome P450-catalyzed carbene transfer reactions K Chen, SQ Zhang, OF Brandenberg, X Hong, FH Arnold Journal of the American Chemical Society 140 (48), 16402-16407, 2018 | 105 | 2018 |
| Stereoselective enzymatic synthesis of heteroatom-substituted cyclopropanes OF Brandenberg, CK Prier, K Chen, AM Knight, Z Wu, FH Arnold ACS Catalysis 8 (4), 2629-2634, 2018 | 95 | 2018 |
| A general and practical palladium-catalyzed monoarylation of β-methyl C(sp³)–H of alanine K Chen, SQ Zhang, JW Xu, F Hu, BF Shi Chemical Communications 50 (90), 13924-13927, 2014 | 77 | 2014 |
| Engineering cytochrome P450s for enantioselective cyclopropenation of internal alkynes K Chen, FH Arnold Journal of the American Chemical Society 142 (15), 6891-6895, 2020 | 76 | 2020 |
| Stereoselective alkoxycarbonylation of unactivated C(sp³)–H bonds with alkyl chloroformates via Pd(II)/Pd(IV) catalysis G Liao, XS Yin, K Chen, Q Zhang, SQ Zhang, BF Shi Nature communications 7, 12901, 2016 | 71 | 2016 |
| Practical synthesis of anti-β-hydroxy-α-amino acids by Pd(II)-catalyzed sequential C(sp³)‒H functionalization K Chen, SQ Zhang, HZ Jiang, JW Xu, BF Shi Chemistry-A European Journal 21 (8), 3264-3270, 2015 | 64 | 2015 |
Frances ArnoldProfessor of chemical engineering, CaltechVerified email at cheme.caltech.edu
